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THE NEED TO CHARACTERIZE COMPLEX ORGANIC COMPOUNDS FOR BIOTECHNOLOGY APPLICATIONS, SUCH AS PROTEIN SEQUENCING, HAS PLACED STRINGENT REQUIREMENTS ON THE DEVELOPMENT OF CHARACTERIZATION TOOLS. RECENT DEVELOPMENTS IN CLUSTER ION FORMATION AND ION BOMBARDMENT DESORPTION THEORY SUGGEST THATCLUSTER ION BOMBARDMENT OF COMPLEX MOLECULES MAY PROVIDE A MECHANISM TO CHARACTERIZE COMPLEX SPECIES AND SIGNIFICA ...

ALUMINUM HAS BEEN IMPLICATED IN NEUROLOGICAL AND AGING DISORDERS, INCLUDING ALZHEIMER'S DISEASE AND DIALYSIS DEMENTIA. PREVIOUS TRACE ANALYSIS STUDIES WERE SUBJECT TO INTERFERENCES AND CONTAMINATION, AND LACKED ELEMENTAL SPECIFICITY, SENSITIVITY, AND ISOTOPIC INFORMATION. RESONANCE IONIZATION SPECTROSCOPY (RIS), WHICH UTILIZES LASER ATOM COUNTING TECHNIQUES, OFFERS THE POTENTIAL TO OVERCOME THESE ...

A NEW, INNOVATIVE KIT FOR PARENT SCREENING OF INFANT HEARING(0-24 MONTHS) WILL BE DEVELOPED AND GIVEN TO 300 PARENT PAIRS TO VALIDATE A HOME SCREENING PROGRAM, USING SPECIAL FREQUENCY SOUND-MAKERS. OF THE APPROXIMATELY 4,000,000 BABIES BORN IN THE UNITED STATES EACH YEAR, OVER 1,000,000 DEVELOP HEARING PROBLEMS FROM RECURRENT OTITIS MEDIA DURING THEIR FIRST 24 MONTHS. APPROXIMATELY 8,000 OF THESE ...

A SINGLE-CHIP ENGINE FOR TOMOGRAPHIC RECONSTRUCTION IS PROPOSED BY COMPUTER TECHNOLOGY AND IMAGING, INC. THE ENGINE WOULD BE FABRICATED USING CURRENT VLSI TECHNOLOGY. SUCH AN ENGINE CAN BE REPLICATED AND USED TO IMPLEMENT A RECONSTRUCTION PROCESSOR. A PROCESSOR USING JUST EIGHT OF THE VLSI ENGINES COULD HAVE A PRICE/PERFORMANCE ENHANCEMENT OVER CURRENT COMMERCIAL RECONSTRUCTION PROCESSORS OF A FAC ...

THE PURPOSE OF THIS RESEARCH IS PRODUCTION AND TESTING OF A NEEDLE-IMPLANTABLE DEVICE FOR ESTIMATING LONG-TERM TISSUE AVAILABILITY OF THE HORMONE CORTICOSTERONE IN RATS. THIS WORK CONTRIBUTES TO THE LONG-TERM GOAL OF DEVELOPING A SIMILAR DEVICE FOR MEASUREMENT OF THE TISSUE AVAILABILITY OFA BROAD RANGE OF COMPOUNDS IN BOTH RESEARCH AND MEDICAL SETTINGS. THE DEVICE OPERATES ON THE DIFFUSION-SINK PR ...

THE PROPOSED RESEARCH WILL TEST THE APPLICABILITY OF A NEW METHOD FOR TIME-INTEGRATING MEASUREMENT OF THE TISSUE AVAILABILITY OF HORMONES, TO THE OVARIAN HORMONE ESTRADIOL. THE NEW METHOD USES AN ULTRAMINIATURE DEVICE, INSTALLED IN THE MOUTH OF A SUBJECT, TO CONTINUOUSLY ACCUMULATE HORMONES FROM THE SALIVA. THE RATE OF ACCUMULATION AT ANY MOMENT DIRECTLY REFLECTS THE AVAILABILITY OF THE HORMONE TO ...

IT IS PROPOSED TO DEVELOP A PULSED HYDROGEN FLUORIDE (HF) CHEMICAL LASER SYSTEM THAT IS SPECIFICALLY DESIGNED FOR USE IN CORNEAL MICROSURGERY. LASER PARAMETERS SUCH AS PULSE ENERGY, PULSE DURATION, BEAM QUALITY, AND OUTPUT SPECTRA WILL BE OPTIMIZED FOR APPLICATION IN CORNEAL MICROSURGERY. ISSUES RELATED TO USE IN A MEDICAL ENVIRONMENT, SUCH AS LASER SIZE AND PACKAGING, FUELS AND EXHAUST HANDLING, ...