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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Micro Patterned Intraocular Lens Membrane for Reducing Incidence of PCO

    SBC: Sharklet Technologies Inc.            Topic: N

    DESCRIPTION provided by applicant The exponential increase of diabetics and the elderly in the U S has more than tripled the number of cataract surgeries performed in just two decades As many as half of these surgeries will lead to posterior capsular opacification PCO which requires follow up Nd YAG laser capsulotomy surgery Without this additional procedure patients can suffer permanent ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Single Somatic Cell Epigenetic Models

    SBC: Topogen, Inc            Topic: 200

    DESCRIPTION provided by applicant Epigenetic modifications of DNA and histones are stable encryption systems essential for life For example the importance of DNA methylation is underscored by the consequences of its mis regulation which include defects in tissue homeostasis chronic disease and accelerated aging thus epigenetics broadly impacts human health The information stored in the di ...

    SBIR Phase I 2015 Department of Health and Human Services
  3. Location-based Smartphone Technology to Guide College Students??? Healthy Choices Phase II

    SBC: KLEIN BUENDEL, INC            Topic: NCCDPHP

    DESCRIPTION provided by applicant Poor eating habits sedentary behavior and deficient sleep quality are problematic for many college students Surrounded by numerous unhealthy food choices and physical activity barriers students are vulnerable to overweight and chronic diseases such as diabetes heart disease and cancer Todayandapos s college students are more technologically connected tha ...

    SBIR Phase II 2015 Department of Health and Human Services
  4. Optimization and Lead Selection of Novel Antimycobacterial Agents

    SBC: CRESTONE, INC.            Topic: 300

    DESCRIPTION provided by applicant The nontuberculous Mycobacteria NTM are a growing public health concern as the number of opportunistic infections increases Although not a reportable disease there is growing epidemiologic evidence to suggest that NTM cause more infections today in the United States than Mycobacterium tuberculosis Mtb yet unlike Mtb there are few dedicated antimicrobial ...

    SBIR Phase II 2015 Department of Health and Human Services
  5. BMX-001 as a Therapeutic Agent for Treatment of High-Grade Gliomas

    SBC: BIOMIMETIX JV LLC            Topic: NCI

    DESCRIPTION provided by applicant Phase and Phase clinical trials of a new class of redox active pharmaceutical are proposed in high grade glioma WHO grade III and IV This project will test a compound that crosses the blood brain barrier and which prevents hippocampal stem cell loss and white matter degradation following radiation therapy RT The compound also inhibits tumor regrowth f ...

    SBIR Phase II 2015 Department of Health and Human Services
  6. Personal Exposure Monitoring of the Air Pollutants as a K-12 Educational Tool

    SBC: 2B TECHNOLOGIES, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant Personal Exposure Monitoring of Air Pollutants as an Educational Tool in the GO Treks project launched by the Phase I grant students at schools throughout the U S used personal monitors to measure the air pollutants black carbon and ozone along treks of their own design The treks were uploaded to blogs in the GO website where they were displ ...

    SBIR Phase II 2015 Department of Health and Human Services
  7. Enhanced multiphoton microscopy through spatial light modulation

    SBC: Boulder Nonlinear Systems, Inc.            Topic: 102

    DESCRIPTION provided by applicant Nonlinear optical microscopy techniques and particularly multiphoton fluorescence microscopy have become popular tools for visualizing the three dimensional cellular architecture residing hundreds of microns and up to one millimeter deep in living organisms This is particularly valuable in neurobiology where multiphoton techniques have become widely used fo ...

    STTR Phase II 2015 Department of Health and Human Services
  8. Beam Control with a Broadband, High Speed X-Y Variable Light Modulator

    SBC: Boulder Nonlinear Systems, Inc.            Topic: 400

    DESCRIPTION provided by applicant The primary proposed objective is to realize a broadband high speed spatial light modulator SLM for microscopy applications Current microscopy techniques frequently employ spatial light modulators to manipulate the phase and amplitude of light illuminating a sample or and or transmitted by a sample The phase and amplitude of light in the microscope illumina ...

    SBIR Phase II 2015 Department of Health and Human Services
  9. Flexible CPU-GPU computational plasma applications with particles and fluids

    SBC: TECH-X CORPORATION            Topic: SB143002

    Theoretical computing speeds have increased dramatically in the last decade with chip advances, including Graphics Processor Units (GPUs).In practice, however, these gains have not been realized, largely due to the accompanying high development costs due to the need for multiple code bases to take advantage of the various chips and their variants.The proposed project addresses these issues from bo ...

    SBIR Phase II 2015 Department of DefenseDefense Advanced Research Projects Agency
  10. Migrate enzyme modeling technology from development site to experimental research

    SBC: Stewart, James            Topic: 300

    Project Summary Abstract The rate of progress in developing new pharmaceuticals could be accelerated if experimental researchers had practical methods for modeling enzyme mechanisms Unfortunately all current programs have severe limitations either being too slow too complicated or too inaccurate Although an efficient and accurate method for modeling mechanisms in enzyme catalyzed reactions ...

    SBIR Phase II 2015 Department of Health and Human Services

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