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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Targeted Nanotherapy to Donor Organ Endothelia Modulates Early Immune Responses and Protects Against Late Graft Failure

    SBC: ToleRaM NanoTech LLC            Topic: NIBIB

    ABSTRACT Transplantation is an accepted and highly successful therapy for end stage organ diseaseWhile success rates and survival have risen steadilydue largely to improved immunosuppression regimesthere is a growing appreciation that damage and inflammation that occur early in the life of the graftsignificantly impact chronic rejection and thus long term survivalCentral to these early event injur ...

    STTR Phase I 2018 Department of Health and Human Services
  2. Emodin as a complementary dietary therapy to reduce toxicity of 5 fluorouracil

    SBC: AcePre, LLC            Topic: R

    PROJECT SUMMARYfluorouracilFUhas been the first choice chemotherapy drug for colorectal cancerCRCfor many yearshoweverits clinical utility remains hindered by hematopoietic and gastrointestinal toxicities resulting from its non selectivitySide effects include fatigueloss of appetiteand diarrhea among othersall of which can lead to reduced quality of lifeThe economic burden associated with chemothe ...

    STTR Phase I 2018 Department of Health and Human Services
  3. Automation of bioengineered epithelial construct cryopreservation

    SBC: TISSUE TESTING TECHNOLOGIES LLC            Topic: NIBIB

    ABSTRACT BSTRACT In an effort to reduce the use of animals for toxicity testingcompanies have developed bioengineered in vitro skin models to replace the Draize skin irritation testThe development of tissue models has been further pushed by the European Union that prohibited the use of animals infor collecting toxicological data on cosmetic ingredientsSupply of bioengineered tissues is a significa ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Mitigating Injurious Falls in Older Adults Through Non-Injurious Fall and Gait Analysis From Floor Vibrations

    SBC: ADVANCED SMART SYSTEMS AND EVALUATION TECHNOLOGIES, LLC            Topic: NIA

    Project Summary and Abstract Falls are the leading cause of death due to injuryThis simple motion is so common thatof community dwelling older adultsandof long term care facilities will experience a fall in the coming yearThe risk of falling substantially increases for those having Alzheimer s disease and related dementiasand those with Parkinson s diseaseThe financial burden is significant with f ...

    STTR Phase I 2018 Department of Health and Human Services
  5. Novel therapeutic approach in treatment of glioblastoma using sustained delivery of Connxin43 carboxy-terminal peptide encapsulated in biodegradable nanoparticles in combination with temozolomide

    SBC: FirstString Research, Inc            Topic: 102

    PROJECT SUMMARY GlioblastomaGBMis an incurable cancer even with aggressive therapies such as surgical resection followed by radiotherapy and chemotherapy using temozolomideTMZEfforts to improve surgical resection or the efficacy of irradiation are limited by the potential damage these interventions cause to the brainIn contrastsensitizing GBM to TMZ is an appealing strategy because TMZ has excelle ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. RoboHear device:advanced haptic technology that allows deaf to understand speech

    SBC: FAUXSEE INNOVATIONS LLC            Topic: NIDCD

    Project Summary AbstractIn the USthere areM adults with hearing difficultiesand overM are profoundly deafi eunable to hear speech or participate in a normal conversationGloballyM people have disabling hearing lossDeafness can be debilitating and greatly affects an individual s socialeducational and occupational prospectsCurrentlythe major medical treatment for deafness is a cochlear ear implantThi ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Construction and testing of a rabbit cornea-equivalent for evaluation of chemical injury in vitro

    SBC: TISSUE TESTING TECHNOLOGIES LLC            Topic: NIEHS

    ABSTRACTWe propose combination of the rabbit cornea endothelial and epithelial cells with bioengineered scaffolds in cell culture well insertsThis technology could significantly reduce the use of rabbits for the Draize rabbit eye irritation assayThe barrier to commercialization is the lack of an effective method for storingbankingof living bioengineered cornea equivalentsWe will combine cell expan ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Rugged, Long-Life Flow Monitoring for Enhanced Geothermal Systems

    SBC: OZARK INTEGRATED CIRCUITS, INC.            Topic: 12a

    Access to the earth’s subsurface requires technologies that can operate at extremely high temperatures and pressures. Enhanced geothermal systems (EGS) require drilling deep and hot wells; while making better use of each well through techniques such as fracking and zonal isolation. Establishing a well requires monitoring electronics that can produce temperature, pressure and flow profiles in the ...

    SBIR Phase II 2018 Department of Energy
  9. SBIR Phase I: Hydrothermal Growth Strontium Beryllium Borate (SBBO) for deep UV Nonlinear Optical Applications.

    SBC: HT CrystalSolutions LLC            Topic: PH

    The?broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is represented by the development of a company in a unique field of single crystal growth addressing needs in solid-state lasers. Single crystal growth represents a small and highly specialized, but absolutely essential, area of modern materials technology. Solid-state lasers are commercially ...

    SBIR Phase I 2018 National Science Foundation
  10. Wireless Movement Sensing System for People with Severe Disabilities

    SBC: INVOTEK, INC.            Topic: NIDCD

    Abstract The ability of people with severe physical impairment to participate in family lifecommunicationworkor recreation is severely restricted without access to assistive technologyATYetas disability severity increasesso does the challenge to findingan access movement that a person can perform to control AT andan access technology that can detect the access movementWe propose to create a wirele ...

    SBIR Phase I 2018 Department of Health and Human Services

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