Award Data

This Small Business Innovative Research (SBIR) Phase I project demonstrates the feasibility of producing stearidonic acid from microalgae for human consumption to combat cardiovascular diseases (CVD). The cardiovascular benefits of fish oil enriched in omega-3 polyunsaturated fatty acids (n-3 PUFAs) are well-documented. Despite overwhelming evidence and strong recommendations supporting the health ...

DESCRIPTION (provided by applicant): Chronic, neuropathic pain is one of the most important unmet medical needs in the United States, affecting tens to hundreds of millions of people nationwide at some time during their lives. Novel therapeutic approaches are desperately needed. The brain peptides neurotensin (NT) and its fully active derivative NT[8- 13] have been shown to exhibit considerable, l ...

The accurate numerical prediction of hazardous airborne plumes requires two important capabilities. First, meteorological conditions at fine spatial scale both at the time of plume release as well as a few hours into the future, and second, quantification of this information in a statistically reliable probabilistic framework. The proposed study will use a combination of fine-scale ensemble re-fo ...

Brushfire Technologies proposes to adapt our secure local area network gateway to the unique requirements of the DMO network to detect, analyze and mitigate security threats in real time with no adverse affects on network performance. Security analysis based on real time packet inspection coupled with application awareness and heuristically derived network topology information provides unpreceden ...

DESCRIPTION (provided by applicant): Assays are being developed in efforts to reduce the number of animals required for research. In particular, cell based systems that can evaluate a variety of compounds and/or screen single compounds with many cell types would provide the most advantageous platforms. These types of assay systems would be applicable to drug discovery, toxicology testing and envir ...

DESCRIPTION (provided by applicant): Transplantation of islets of Langerhans for the clinical treatment of Type I diabetes has had a resurgence of interest due to results obtained using the "Edmonton protocol". However, at this time, procurement of donor pancreases for islet isolation and transplantation is in its infancy. Most pancreases at more remote donor sites are not procured due to justifie ...

DESCRIPTION (provided by applicant): Allogeneic human heart valves are used in approximately 20% of the tissue heart valve procedures performed annually. Most allogeneic human heart valves (also known as allografts or homografts) are cryopreserved and stored in the vapor phase of liquid nitrogen storage freezers. During shipping from the preservation facility to the surgical point of use, the hear ...

DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of blindness in the world. Diabetic macular edema (DME) and retinal neovascularization (NV) are the two major pathological alternations leading to the vision loss in diabetic retinopathy. Angiogenesis and inflammation play a crucial role in the pathogenesis of DR. Inflammatory ce ...

DESCRIPTION (provided by applicant): Vascular leakage or increased vascular permeability in the retina is a common abnormality of diabetic retinopathy and can result in diabetic macular edema (DME), a major cause of vision loss in diabetic patients. Currently, there is no effective drug therapy to treat DME, and DME affects millions of people in the US alone. Over-expression of vascular endothelia ...

A longwire antenna module is proposed, incorporating a length reduction technique that yields 25-75% length reduction with minimal impact on gain. A resonant monopole antenna operating at 535kHz is approximately 440ft long; length reduction techniques will reduce this to between 69ft and 134ft depending upon the desired gain. A shorter/lighter longwire antenna will allow the aircraft to be more ...