Award Data

Project Abstract In this Phase I proposalVulintusIncproposes to develop and testOmniHomea wirelessself contained home cage system for assessing fine motor function in rodentsCurrent methods for longitudinally assessing skilled motor function in aging rodent models are labor intensivetime consuming to administer frequently over long timescalesand stressful to the animalThe proliferation of new rode ...

SummaryAbstractOur group has recently licensed a technology enabling the identificationisolationand subsequent expansion ofyouthfulmesenchymal stem cellsMSCsfrom elderly individualsThis population is characterized by small size and expression of stage specific embryonic antigenSSEAPrior work indicates that smallSSEAsmallMSCsfunction in a manner similar to that of MSCs from young individualsMoreove ...

TITLEImplantable Wireless Telemetric Monitoring Device For Aging Studies In MiceABSTRACTThere has been a dramatic growth in aging research particularly using small animals such as mice to find translatable solutions to improve the health span as we ageWhile undisturbed and non tethered acquisition of physiologic data in awake mice using implantable wireless telemetry technologies reflects the most ...

The over arching goal of this Phase I SBIR proposal is to begin to optimize and implement standard reference diets for the ZebrafishDanio rerioan animal model of critical importance to the understanding of human health and development of vertebrate organismsA key problem in the industry is that standardized diets or feed management strategies have not been developed for Danio rerioThese diets are ...

Project Abstract Currently available commercial systems for automated home cage health and behavioral monitoring of small animal research models are typically expensive and do not work universally with researchersexisting vivarium cage systemsFor this Phase I SBIR projectVulintusIncproposes to develop and validateHabiTraka miniature low costwireless device for continuously monitoring small animal ...

ABSTRACT Transplantation is an accepted and highly successful therapy for end stage organ diseaseWhile success rates and survival have risen steadilydue largely to improved immunosuppression regimesthere is a growing appreciation that damage and inflammation that occur early in the life of the graftsignificantly impact chronic rejection and thus long term survivalCentral to these early event injur ...

Severe loss of vision occurs due to age-related macular degeneration (AMD) and approximately 15 million people in the US have some form of AMD, which is expected to double by 2050. Most of the current clinical treatments are primarily focused on slowing down the progression of the disease, as there is neither a cure that can stop the degeneration nor a therapy, other than retinal prostheses, that ...

TITLEUltrasonic Telemetric Implantable Pulsed Doppler Blood Flow Velocimeter for Small Animals ABSTRACT Ultrasonic Pulsed Doppler devices for measuring flow velocities in blood vessels of small animals such as mice are routinely used by cardiovascular researchers for preclinical researchUndisturbed and non tethered acquisition of physiologic data in awakeunanesthetizedanimals using wireless teleme ...

Abstract Systemic sclerosissclerodermaSScis a chronic connective tissue disease in which lung fibrosis is the most frequent cause of deathSSc and idiopathic pulmonary fibrosis are the two most common disease that falls under the interstitial lung diseasesILDa grouping of devastating diseases in which lung fibrosis leads to progressive shortness of breatha very poor quality of lifeand death within ...

PROJECT SUMMARY Heart failure is a leading cause of mortality throughout the worldThe only viable life sustaining option for patients with advanced heart failure is a heart transplantDue to the complex nature of the heart transplant procedure and the limited supply of donor heartsmost of these patients tend to use Left Ventricular Assist DevicesLVADseither to bridge the gap until they can undergo ...