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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Plan Learning Across Textual Observations (PLATO) Phase II

    SBC: LANGUAGE COMPUTER CORPORATION            Topic: DTRA162004

    In Phase II of PLATO, we will develop a prototype plan and goal identification system that employs a rich model of domain actions and events, extracted automatically from a massive amount of real-world domain-relevant information, to model agent-specific action costs and to process sequences of agent actions and events, extracted from text, as an agent plan in progress. The system will be able to ...

    SBIR Phase II 2018 Department of DefenseDefense Threat Reduction Agency
  2. Home Cage System for Fine Motor Assessments in Aging Rodent Models

    SBC: VULINTUS, INC.            Topic: NIA

    Project Abstract In this Phase I proposalVulintusIncproposes to develop and testOmniHomea wirelessself contained home cage system for assessing fine motor function in rodentsCurrent methods for longitudinally assessing skilled motor function in aging rodent models are labor intensivetime consuming to administer frequently over long timescalesand stressful to the animalThe proliferation of new rode ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Small Molecule Inhibitor Therapeutic Target for Alzheimer's Disease.

    SBC: abSynapTex, LLC            Topic: NIA

    Project SummaryThe objective of our proposed research is to develop a water soluble molecule that can reduce the levels of amyloid betaAand Drpand prevent abnormal interactions between Aand Drpin Alzheimers diseaseADaffected neuronsOur previous AD studies foundincreased production and accumulation of Aand increased expression of Drpandan abnormal interaction between Aand Drpin AD neurons that was ...

    STTR Phase I 2018 Department of Health and Human Services
  4. Emodin as a complementary dietary therapy to reduce toxicity of 5 fluorouracil

    SBC: AcePre, LLC            Topic: R

    PROJECT SUMMARYfluorouracilFUhas been the first choice chemotherapy drug for colorectal cancerCRCfor many yearshoweverits clinical utility remains hindered by hematopoietic and gastrointestinal toxicities resulting from its non selectivitySide effects include fatigueloss of appetiteand diarrhea among othersall of which can lead to reduced quality of lifeThe economic burden associated with chemothe ...

    STTR Phase I 2018 Department of Health and Human Services
  5. Mitigating Injurious Falls in Older Adults Through Non-Injurious Fall and Gait Analysis From Floor Vibrations

    SBC: ADVANCED SMART SYSTEMS AND EVALUATION TECHNOLOGIES, LLC            Topic: NIA

    Project Summary and Abstract Falls are the leading cause of death due to injuryThis simple motion is so common thatof community dwelling older adultsandof long term care facilities will experience a fall in the coming yearThe risk of falling substantially increases for those having Alzheimer s disease and related dementiasand those with Parkinson s diseaseThe financial burden is significant with f ...

    STTR Phase I 2018 Department of Health and Human Services
  6. Developing an automated yeast dissection system for aging research

    SBC: Innovative BioChips LLC            Topic: NIA

    PROJECT SUMMARY Developing an Automated Yeast Dissection System for Aging ResearchAging is the single greatest risk factor for diseases that are principal causes of mortalityThe objectives of aging research are to discover key genes and pathways related to aging that may eventually contribute to retardation of aging and a delay in the onset of age associated diseasesThe budding yeast Saccharomyces ...

    STTR Phase II 2018 Department of Health and Human Services
  7. IMPLANTABLE WIRELESS TELEMETRIC MONITORING DEVICE FOR AGING STUDIES IN MICE

    SBC: INDUS INSTRUMENTS            Topic: NIA

    TITLEImplantable Wireless Telemetric Monitoring Device For Aging Studies In MiceABSTRACTThere has been a dramatic growth in aging research particularly using small animals such as mice to find translatable solutions to improve the health span as we ageWhile undisturbed and non tethered acquisition of physiologic data in awake mice using implantable wireless telemetry technologies reflects the most ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Dose-ranging safety and efficacy studies to advance novel mechanism-of-action drug candidates to reverse age-related muscle degeneration

    SBC: RIDGELINE THERAPEUTICS LLC            Topic: NIA

    In the USthe number of individuals agedand older will increase byover the next decadeConcurrentlyMedicare costs are expected to double to treat chronic diseases that will plague this increasing number of older adultsOne of the most wide spread chronic diseases that affects older adults is sarcopeniawhich is observed inof adults overyears of age andof adults overyears of ageThis disease is characte ...

    STTR Phase I 2018 Department of Health and Human Services
  9. Innovative Delivery of siRNA across the Blood Brain Barrier

    SBC: Fannin Partners, LLC            Topic: NIA

    Project Summary Drug delivery across the blood brain barrier is a significant challenge in developing successful therapeutics for brain malignanciesDespite significant advances in developing small moleculespeptidesand nucleic acid treatment optionssuccessful delivery of these molecules to the brain diminishes their promiseWe propose a novel approach of delivering small interfering RNAsiRNAacross t ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Expansion of "youthful" mesenchymal stem cells from elderly individuals for autologous cell-based therapies

    SBC: Stembiosys, Inc            Topic: NIA

    SummaryAbstractOur group has recently licensed a technology enabling the identificationisolationand subsequent expansion ofyouthfulmesenchymal stem cellsMSCsfrom elderly individualsThis population is characterized by small size and expression of stage specific embryonic antigenSSEAPrior work indicates that smallSSEAsmallMSCsfunction in a manner similar to that of MSCs from young individualsMoreove ...

    SBIR Phase I 2018 Department of Health and Human Services

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