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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. RAPID ASSAY FOR HUMAN A(1)-PROTEINASE INHIBITOR DEFICIENCY

    SBC: Athens Research And Technology            Topic: N/A

    THIS PROPOSAL INVOLVES THE DEVELOPMENT OF A SIMPLE ASSAY FORMEASURING FUNCTIONAL (1)-PROTEINASE INHIBITOR LEVELS IN HUMAN TISSUES. THE PROCEDURE UTILIZES THE FACT THAT INCUBATION OF EXCESS PORCINE PANCREATIC ELASTASE WITH EITHER PLASMA OR SERUM SAMPLES WILL RESULT IN COMPLEX FORMATION WITH FUNCTIONAL (1)-PROTEINASE INHIBITOR IN THESE FLUIDS. RESIDUAL ENZYME ACTIVITY CAN THEN BE CALCULATED AND A DE ...

    SBIR Phase II 1989 Department of Health and Human Services
  2. POLYMERIC MEMBRANE APPLICATIONS TO IMPROVE CELL CULTURE

    SBC: Athens Research And Technology            Topic: N/A

    CAPS OF CELL CULTURE FLASKS USED IN CONJUNCTION WITH BICARBONATE BUFFER SYSTEMS MUST BE LEFT PARTIALLY OPEN TO ALLOW FOR CARBON DIOXIDE EXCHANGE. THE PRESENCE OF AIRBORNECONTAMINANTS OR LEAKAGE OF MEDIA INTO THE THREADS OF THE CAPTHREATENS TO CONTAMINATE THE CULTURE. CONVERSELY, TIGHTENING THE CAP TOO MUCH LEADS TO THE LOSS OF SOME CULTURES BECAUSE OF IMPROPER GAS EXCHANGE. CELLGRO RESEARCH (CGR) ...

    SBIR Phase I 1989 Department of Health and Human Services
  3. ACOUSTIC PLATE MODE MICROSENSOR FOR NUCLEIC ACIDS

    SBC: BIODE, INC.            Topic: N/A

    BIODE, INC., WILL UTILIZE THE RESULTS OF ITS PHASE I RESEARCH TO DEVELOP A TOTALLY NEW SOLID-STATE SENSOR TECHNOLOGY FOR BIOLOGICAL MEASUREMENTS. THIS TECHNOLOGY IS BASED UPON THE MERGING OF TWO OTHER RELATIVELY NEW TECHNOLOGIES: NUCLEIC ACID PROBES (NUCLEIC ACID HYBRIDIZATION) WITH ACOUSTIC PLATE MODE (APM) MICROSENSORS. BY COMBINING THE SENSITIVITY OF APM SENSORS WITH THE SPECIFICITY OF NUCLEIC ...

    SBIR Phase I 1989 Department of Health and Human Services
  4. LIQUID-GUIDED ACOUSTIC WAVE IMMUNOSENSOR

    SBC: BIODE, INC.            Topic: N/A

    BIODE, INC., WILL UTILIZE THE RESULTS OF ITS PHASE I RESEARCH TO DEVELOP A TOTALLY NEW SOLID-STATE BIOSENSOR TECHNOLOGY FOR BIOLOGICAL MEASUREMENTS. THIS TECHNOLOGY IS BASED UPON THE MERGING OF TWO OTHER RELATIVELY NEW TECHNOLOGIES, MONOCLONAL ANTIBODIES (HYBRIDOMA TECHNOLOGY) WITH ACOUSTIC WAVE MICROSENSORS. BY COMBINING THE SENSITIVITY OF ACOUSTIC WAVE SENSORS WITH THE SPECIFICITY OFANTIBODIES, ...

    SBIR Phase I 1989 Department of Health and Human Services
  5. PREVENTION OF CALCIFICATION OF CARDIOVASCULAR PROS

    SBC: Biomedical Design Inc.            Topic: N/A

    THE FAILURE OF CARDIOVASCULAR BIOPROSTHESES DUE TO CALCIFICATION IS A MAJOR CLINICAL PROBLEM. THE DERIVATIVE OF A NATURAL COMPOUND HAS BEEN SYNTHESIZED; WHEN IT REACTED WITH GLUTARALDEHYDE-PRESERVED TISSUE, IT PREVENTED CALCIFICATION IN SUBCUTANEOUS BOVINE PERICARDIUM IMPLANTED FOR 21 DAYS IN 3-WEEK OLD RATS. THE LONG-TERM EFFICACY OF THIS COMPOUND IS CURRENTLY BEING INVESTIGATED. THE OBJECTIVE OF ...

    SBIR Phase I 1989 Department of Health and Human Services
  6. ITEM DEVELOPMENT AND PILOT TESTING OF THE MAP-SCREEN

    SBC: Developmental Technologies            Topic: N/A

    DEVELOPMENTAL TECHNOLOGIES PROPOSES TO DEVELOP THE MAP-SCREEN, A SHORT SCREENING TEST TO DETERMINE WHICH PRESCHOOL-AGED CHILDREN ARE AT RISK FOR LEARNING DISABILITIES. THE MAP-SCREEN WILL BE DEVELOPED FROM THE RESEARCH OF THE MILLER ASSESSMENT FOR PRESCHOOLERS (MAP), A MORE COMPREHENSIVE, PREDICTIVE INSTRUMENT, AND SERVE AS A COMPANION PRODUCT TO THE MAP. THE MAP-SCREEN IS BEING PROPOSED IN DIRECT ...

    SBIR Phase II 1989 Department of Health and Human Services
  7. GLYCOSYLTRANSFERASE LUMINESCENCE ASSAY: A NEW TECHNOLOGY

    SBC: Ela Technologies Inc            Topic: N/A

    ALTERATIONS IN GLYCOSYLTRANSFERASE ACTIVITIES HAVE BEEN CORRELATED WITH CERTAIN PATHOLOGICAL CONDITIONS AND DISEASESIN ANIMALS. THE CURRENT TECHNOLOGY FOR ASSAYING THESE ENZYMES IS NOT READILY ADAPTABLE FOR LARGE-SCALE CLINICAL SCREENING AND DIAGNOSTICS. IN THESE STUDIES, A NEW AND GENERAL METHOD WILL BE DEVELOPED FOR ASSAYING GLYCOSYLTRANSFERASES. THIS NEW TECHNIQUE IS RAPID, 3 TO 6 ORDERS OF MAG ...

    SBIR Phase I 1989 Department of Health and Human Services
  8. MINIMALLY STRESSFUL MEASUREMENT OF HORMONE AVAILABILITY

    SBC: Hammersmith Laboratories Inc            Topic: N/A

    RECENT RESEARCH POINTS OUT THE POTENTIAL IMPORTANCE OF HORMONAL FACTORS IN THE DEVELOPMENT OF COGNITIVE AND AFFECTIVE DISORDERS OF AGING. BECAUSE ANIMAL MODELS OF THE COGNITIVE DISORDERS OF AGING EXIST, IT IS DESIRABLE TO STUDY HORMONAL CONTRIBUTIONS TO THE DEVELOPMENT OF THESE DEFICITS IN ANIMALS. WITH TRADITIONAL METHODS, IT IS EXTREMELY DIFFICULT TO MAKE MEANINGFUL MEASUREMENTS OF THE ENDURING ...

    SBIR Phase I 1989 Department of Health and Human Services
  9. POLYMERIC MEMBRANE BARRIERS FOR ANIMAL ISOLATION

    SBC: Horizon Micro-environments            Topic: N/A

    N/A

    SBIR Phase I 1989 Department of Health and Human Services
  10. FTLV AS A SMALL LABORATORY MODEL OF HIV

    SBC: Idexx Corp.            Topic: N/A

    N/A

    SBIR Phase I 1989 Department of Health and Human Services

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