Award Data

THE OBJECTIVE OF THIS RESEARCH AND DEVELOPMENT PROGRAM IS TO DEMONSTRATE THE TECHNICAL FEASIBILITY OF DETECTING AND MONITORING ISOCYANATES IN WORKPLACE AIR AT OR BELOW THE THRESHOLD LIMIT VALUE (TLV) 0.02 PPM USING A REAL-TIME MONITORING TECHNIQUE. THE INSTRUMENT WILL DETECT AND ANALYZE FOR ISOCYANATES IN BOTH VAPOR AND AEROSOL FORM AND WILL SERVE AS A WORKPLACE MONITOR FOR ISOCYANATES TO REPLACE ...

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THE RESEARCH IS BASED ON A NOVEL CONCEPT OF FLOW ANALYSIS, WHICH POSTULATES THAT THE LINEAR CONSTANT MONOTONOUS FLOW RATE AS NOW GENERALLY ADOPTED IN ALL TYPES OF FLOW ANALYSIS, CAN BE REPLACED BY A FLOW PATTERN, AS LONG AS THIS FLOW PATTERN CAN BE MAINTAINED AND STRICTLY REPRODUCED FROM ONE ANALYSIS CYCLE TO THE NEXT. THIS IN TURN ALLOWS USE OF A SINUSOIDAL FLOW, GENERATED BY A PAIRED SYRINGE PUM ...

GENERALLY, OXYGEN AFFINITY INCREASES AFTER TREATMENT OF HEMOGLOBIN S (HBS) WITH COVALENT ANTISICKLING AGENTS, SUCH AS IMIDOESTER CROSSLINKING REAGENTS. ADDING INOSITOL HEXAPHOSPHATE (IHP) DURING THE CROSSLINKING PROCEDURE WILL LOWER THE AFFINITY, PROTECT THE 2,3-DIPHOSPHOGLYCERATE BINDING SITE AND ULTIMATELY IMPROVE OXYGEN DELIVERY TO TISSUES. THE GOAL OF THIS PROJECT IS TO PRODUCE A STABLE HBS TH ...

ALZHEIMER'S DISEASE (AD), A LEADING HEALTH PROBLEM FOR THIS COUNTRY, AFFECTS 5 TO L0 PERCENT OF THOSE OVER 65. BY THE YEAR 2000, THIS AGING POPULATION WILL DOUBLE. A TEST PERMITTING A DEFINITIVE AND EARLY DIAGNOSIS OF AD IS GREATLY NEEDED. WE SEEK TO DEVELOP SUCH A DIAGNOSTIC TEST USING MABS IT HAS RAISED TO A MODIFIED FORM OF ALX. IN PHASE I STUDY, ART WILL CHARACTERIZE ITS MABS, DESIGN A PILOT I ...

NALTREXONE IS AN EFFECTIVE NARCOTIC ANTAGONIST. HOWEVER, ITS EFFECTIVENESS IS LIMITED BY THE NEED FOR HIGH PATIENT COMPLIANCE, AS ORAL DOSAGES MUST BE TAKEN AT LEAST THREE TIMES WEEKLY. BY USING A PROPRIETARY DELIVERY SYSTEM, IT ISEXPECTED THAT NALTREXONE CAN BE DELIVERED AT A CONTROLLED RATE FOR ONE MONTH. THE DELIVERY SYSTEM TO STUDIED IS BIODEGRADABLE AND BIOCOMPATIBLE, AND HAS BEEN SHOWN TO CA ...

WE WILL DEVELOP A BIODEGRADABLE WOUND TREATMENT THAT CAN BE AEROSOLIZED DIRECTLY ONTO A WOUND SURFACE. IT WILL FORM A TOUGH, FLEXIBLE FILM THAT WILL SEAL THE WOUND AND PROVIDE FOR PROPER WATER LEVELS AT THE WOUND SURFACE. AN ANTIBIOTIC WILL BE INCORPORATED INTO THE BIODEGRADABLE POLYMER AND WILL BE SLOWLY RELEASED INTO THE WOUND BOTH TO ELIMINATE EXISTING INFECTION AND TO PREVENT LATER INFECTION. ...

THE LONG-TERM GOAL OF THIS RESEARCH IS TO DEVELOP QUANTITATIVE OPTICAL IMAGING METHODS FOR BIOENERGETIC STUDIES OF TISSUE. METHODS WILL BE DEVELOPED FOR THE OPTICAL DETERMINATION OF TISSUE OR CIRCULATORY OXYGEN CONCENTRATION BASED ON PALLADIUM PORPHYRIN PHOSPHORESCENCE QUENCHING BY COLLISIONAL INTERACTION WITH MOLECULAR OXYGEN. DURING PHASE I, PALLADIUM PORPHYRINS WILL BE SYNTHESIZED AND SOFTWARE ...

THIS PILOT PROJECT WILL TEST A NEW PATENTED MEAL CARD/MENU BOARD SYSTEM'S PRACTICALITY AND ADAPTABILITY FOR USE IN LONG TERM HEALTH CARE FACILITIES. TESTING OF THE PROTOTYPE WILL REQUIRE THE CONSENT OF THE ADMINISTRATION OF THE NURSING HOMES INVOLVED IN THIS PROJECT, TO MODIFY THEIR CURRENT MENU PLANNING TECHNIQUES. IMPLEMENTATION REQUIRES THE ESTABLISHING OF A RESIDENT'S MENU PLANNING COMMITTEE I ...