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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Elucidation of Antisickling Molecules in a Botanical with Antisickling Activity

    SBC: INVENUX, LLC            Topic: NCCAM

    DESCRIPTION: New therapeutic agents are urgently needed for the treatment of sickle cell disease (SCD), the world's most common genetic disease. Our long-term goal is to develop a drug for use in children that prevents the inexorable progression of SCD. SCD affects approximately 100,000 people in the United States and millions worldwide. It kills more children in Africa than HIV, but while HI ...

    STTR Phase I 2013 Department of Health and Human Services
  2. Quantitative dual-mode scanner for breast cancer therapy

    SBC: PET/X LLC            Topic: NCI

    DESCRIPTION (provided by applicant): The goal of this project is to develop a dual-mode PET/x-ray mammography scanner (PET/X) to improve the way in which breast cancer therapies are matched to patients by providing early evaluation of therapy efficacy through 'window' studies on an individual patient basis. More than 200,000 women in the US start therapy for breast cancer each year. In 2 ...

    STTR Phase I 2013 Department of Health and Human Services
  3. The anti-tumorigenic and anti-metastatic potential of Eya phosphatase inhibitors

    SBC: SIXONE SOLUTIONS, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Breast cancer is expected to cause 39,510 deaths of American women in 2012 and 450,000 deaths globally. Once breast cancer has spread, it is essentially incurable. A critical barrier to treating advanced breast cancer is the lack of cancer-specific drugs that are effective in a large percentage of cancer patients and have low toxicity. Sixone Solutions, LLC pro ...

    STTR Phase I 2013 Department of Health and Human Services
  4. Primary Screener for Mathematics (PSM) and Diagnostic Assessment of Math Skills

    SBC: STRETCHING CHARTS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): Based on the poor performance of fourth grade students on national and international tests of mathematics, it is evident students in the early grades are not adequately prepared in mathematics. Several researchers havedemonstrated that students who complete kindergarten with an inadequate knowledge of basic mathematics concepts and skills will continue to exper ...

    STTR Phase I 2013 Department of Health and Human Services
  5. Remote focusing through spatial light modulation for multifocal multiphoton micro

    SBC: Boulder Nonlinear Systems, Inc.            Topic: NIMH

    DESCRIPTION (provided by applicant): Nonlinear optical microscopy techniques (such as two-photon florescence) are being used to acquire volumetric (i.e. three dimensional) images that probe several hundred microns into scattering tissue. These techniques are being combined with fast acquisition schemes to allow imaging of live, moving specimens at high NA. This combination allows for high-resoluti ...

    STTR Phase I 2013 Department of Health and Human Services
  6. Evaluation of the Antigenicity of Black Restricted FVIII Haplotypes and Haplotype

    SBC: Haplomics            Topic: NIMHD

    Evaluation of the Antigenicity of Black-Restricted Haplotypes of Factor VIII ABSTRACT About 30% of congenital Hemophilia A (HA) patients develop alloantibodies that neutralize the activity of replacement Factor (F) VIII proteins. Such patients, who are termed inhibitor patients, are typically treated with so called bypassing agents such as recombinant (r) FVIIa and FEIBA. Bypassing agents are mor ...

    STTR Phase I 2013 Department of Health and Human Services
  7. Monodispersed magnetic nanoparticles for improved diagnostic imaging. Phase II: S

    SBC: LODESPIN LABS, LLC            Topic: NIBIB

    DESCRIPTION (provided by applicant): In the proposed phase II NIH STTR funding opportunity (PA-12-089), LodeSpin Labs (LSL) is developing a magnetic nanoparticle tracer for use in Magnetic Particle Imaging (MPI), a disruptive new medical imaging technologycurrently being developed as a safe, effective and quantitative alternative to existing cardiac imaging technologies like CT and MRI. MPI is a p ...

    STTR Phase II 2013 Department of Health and Human Services
  8. Autologous HIV-1 resistant T cells through accelerated CCR5 gene disruption


    DESCRIPTION (provided by applicant): Treating patients infected with Human Immunodeficiency Virus-1 (HIV-1) is a substantial clinical challenge with evolving pharmaceutical drug and dosing options. Treatments should improve the health and quality of life for HIV-infected individuals by reducing viremia and preserving immunological function. Currents therapeutic approaches utilize combination antir ...

    STTR Phase II 2013 Department of Health and Human Services
  9. High-specificity affinity reagents for N-glycosylation site mapping and glycomics


    DESCRIPTION: Glycans have several distinct properties that make them excellent targets for disease biomarkers. Firstly, the location of the glycans on the cell surface makes them the first point of contact of cellular interactions and thus crucial in thecontrol of normal metabolic processes. Cell surface molecules are also strategically exposed for surveillance by the immune system allowing for t ...

    STTR Phase II 2013 Department of Health and Human Services
  10. Reduce the Risk: An Affect Management Program for HIV Prevention

    SBC: VIRTUALLY BETTER INC            Topic: NIMH

    DESCRIPTION (provided by applicant): The proposed project, titled Reduce the Risk: An Affect Management Program for HIV Prevention, will examine the use of immersive virtual reality technology as an intervention tool for HIV Prevention with adolescents. Adolescents are at risk for contracting HIV. Affect dysregulation is common among adolescents. Research has demonstrated connections between poor ...

    STTR Phase II 2013 Department of Health and Human Services

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