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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Aerosol Sampling and Microfluidic Analysis of Reactive Oxygen Species

    SBC: ILLIONIX, LLC            Topic: 113

    DESCRIPTIONprovided by applicantCardiovascular diseases and Asthma affects betweenandmillion people in the United States includingmillion childrenduring the pastyearsits incidence worldwide has doubledAsthma is responsible formillion person days of restricted activity anddeaths per yearamounting to $billion in direct heath related coststhere is uncertainty about the specific factors that are contr ...

    STTR Phase II 2017 Department of Health and Human Services
  2. Developing a small peptide to control autoimmune inflammation in type diabetes

    SBC: Op-T-Mune, Inc            Topic: NIAID

    Abstract Type Diabetes T D affects an ever growing population While this disease typically has been associated with juveniles the disease in adult populations is rapidly increasing The defining clinical component is insulin loss which occurs because of sustained inflammation in the islets At present there is no means to prevent or reverse insulin loss A major inflammatory pathway in T D ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Novel sanitizer against viral infections with long lasting effect

    SBC: CAMELLIX, LLC            Topic: NIAID

    Project Summary Abstract Despite mandatory use of hand sanitizer on cruise ships there are reported cruise ship onboard norovirus outbreaks in exceeded the number of norovirus outbreaks outbreaks onboard cruise ships in One of the problems of currently available alcohol based hand sanitizer is that alcohol evaporates in less than seconds after each application to a surface ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Anti CCL mAb to treat castration resistant prostate cancer

    SBC: JYANT Technologies, Inc.            Topic: 102

    Metastatic castration resistant prostate cancer CRPC PCa accounts for of PCa deaths and is associated with skeletal metastases CRPC affects patients differently making this disease difficult for physicians to provide standardized treatments with similar outcomes Docetaxel can prolong the overall survival in patients with metastatic CRPC but current therapies do not provide a cure Doce ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Noninvasive Contrast Enhanced Early Detection of Melanoma Liver Metastasis

    SBC: INLIGHTA BIOSCIENCES L.L.C.            Topic: 102

    Abstract The liver is the most common organ for metastasis of various cancersincluding pancreaticovariancolorectalgastric cancers and melanomaUveal melanoma metastasizes inof patients and upon metastasis targets the liver inof these casesThe most common primary malignant liver cancer worldwide is hepatocellular carcinomaHCCThe use of blind liver biopsy as a diagnostic tool for liver cancer has man ...

    STTR Phase II 2017 Department of Health and Human Services
  6. Engineering probiotics to biosynthesize natural substances for microbiome brain research

    SBC: HGG Research LLC            Topic: R

    PROJECT SUMMARY To advance microbiome brain studies the general goals of this collaborative proposal are to provide services to research community by engineering probiotics e g E coli Nissle EcN Bifidobacteria longum Lactobacillus plantarum to biosynthesize various naturally occurring chemicals as prebiotic probiotic conjugates which will be marketed as important laboratory agents ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Large Scale Preparation of Natural Glycans

    SBC: Natglycan, LLC            Topic: 400

    Project Summary Abstract The two major obstacles to progress in glycomics relative to proteomics and genomics are the lack of simple robust and automated methods for determining glycan structures and for synthesis of glycans The net result of this situation is an overall lack of defined glycans for use in functional studies and for use as standards in structural analysis Significant effort has ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. OC Go Facilitating fidelity and dissemination of evidence based treatment for childhood OCD via an interactive crowd sourced patient provider tool

    SBC: VIRTUALLY BETTER INC            Topic: 104

    Project Summary OC Go Facilitating fidelity and dissemination of evidence based treatment for childhood OCD via an interactive crowd sourced patient provider tool The long term objective of this project is to leverage mobile technologies and crowdsourcing to create a new paradigm of evidence based treatment delivery and dissemination as current methods are often insufficient The project seeks ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Small molecule therapy for metastatic prostate cancer

    SBC: MetCure Therapeutics LLC            Topic: 102

    Enzalutamide resistance is a major obstacle in the treatment of metastatic castration resistant prostate cancer mCRPC Recently we developed a small molecule lead compound GH and demonstrated its potent activity against bone metastatic prostate cancer cells In this Phase I STTR application we hypothesize that GH is a novel lead compound with nanomolar potency against enzalutamide resist ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a protein drug for pancreatic cancer treatment

    SBC: ProDa BioTech L.L.C.            Topic: NCI

    Abstract Pancreatic cancers are devastating diseases with five year survival rate less than Currently there is no effective treatment for advanced disease One major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal response Evidence suggests that cancer associated pancreatic stellate cells CAPaSC produce the stromal collagen The ECM laid down by CAPaSC is c ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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