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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Correlating TCR diversity to immune reconstitution after cord blood transplant

    SBC: ADAPTIVE BIOTECHNOLOGIES CORPORATION            Topic: NHLBI

    DESCRIPTION provided by applicant Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA matched sibling or unrelated donor Transplants using stem cells from umbilical cord blood provide an alternative for these patients allowing transplantation to proceed with less stringent HLA matching requirements Unfortunately in addition to t ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A Rapid Paper Strip Nucleic Acid Test for the Point of Care Detection of Zika virus

    SBC: Crosslife Technologies Inc.            Topic: NIAID

    A Rapid Paper Strip Nucleic Acid Test for the Point of Care Detection of Zika virus CrossLife Technologies Inc Project Summary Abstract There are unmet needs for nucleic acids new diagnostics that can be applied at the point of care to detect Zika Virus ZIKV infections A highly sensitive simple paper strip molecular test that detects ZIKV at the point of care will be developed The target seq ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Direct sequencing of serum antibodies after infection

    SBC: MAPP BIOPHARMACEUTICAL, INC.            Topic: NIAID

    Project Summary Monoclonal antibodies mAbs are a well validated drug platform with exquisite specificity diversity and potency They offer the lowest risk class of drug for development through licensure and offer great potential for addressing emerging and re emerging infectious diseases To be prepared as threats like Ebola EBOV Marburg MARV and Zika viruses continue to emerge or re em ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Discriminating viral and bacterial meningitis infections with iDDS probes

    SBC: GENETAG TECHNOLOGY, INC.            Topic: NIAID

    Discriminating viral and bacterial meningitis infections with iDDS probes Confidential PI Shafer David A PhD PROJECT SUMMARY Rapid and accurate molecular diagnostics assays empower physicians to make informed treatment decisions especially when a disease state may result from variable causes that are indeterminable without such testing Meningitis may be caused by infection with microorganism ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Digital serology for parallel parasitic disease detection

    SBC: Serimmune            Topic: NIAID

    The proposed project aims to build a diagnostic test for chronic T cruzi infection and Chagas disease that not only improves testing performance but that can be readily integrated with similarly developed tests for most clinically important parasitoses Current assays for Chagas disease and other parasitic infections lack desired levels of specificity and require multiple independent assays an ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Development of polyvalent inactivated rhinovirus vaccine

    SBC: Meissa Vaccines Inc            Topic: NIAID

    Human rhinovirus RV is the predominant etiological agent of the common cold and the leading cause of human infectious disease RV is more than a nuisance It is a major cause of community acquired pneumonia in children and adults in the United States and plays a major role in triggering exacerbations of both asthma and chronic obstructive pulmonary disease resulting in billions of dollars in me ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of Novel Protease Activity-Based Diagnostics for the Rapid Identification of Candida Infections

    SBC: BioSynesis, Inc.            Topic: NIAID

    PROJECT SUMMARY ABSTRACT Members of the Candida genus of fungi form part of the normal human microbiota but are also opportunistic pathogens capable of causing serious mucosal and systemic infectionsCandida cells grow and divide in suspensionplanktonicculturesbut they also form resilient and drug resistant biofilmsorganizedtightlypacked communities of cells attached to a surfaceBiofilms colonize m ...

    SBIR Phase I 2017 Department of Health and Human Services
  8. Deceased Donor Bone Marrow Salvage and Processing

    SBC: Ossium Health, Inc.            Topic: NIAID

    ABSTRACT This program aims to develop a method for banking clinical grade bone marrow from cadaveric donors that can be deployed nationally to ameliorate shortages provide bone marrow stockpiles as medical countermeasures for nuclear threats and support existing research approaches such as delayed immune tolerance induction and transfusion of HIV resistant stem cells We will adapt a method de ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Development of an Innovative Effective RNA based Vaccine for Chikungunya Virus

    SBC: PAI Life Sciences, Inc.            Topic: NIAID

    PROJECT SUMMARY ABSTRACT Chikungunya virus CHIKV is an emerging disease of global public health importance Originally identified in sporadic CHIKV outbreaks occurred in Africa and Asia for several decades Beginning with an outbreak on the island of La Reunion in the virus has continued to spread to new regions around the globe CHIKV is now endemic in the Caribbean is present in t ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Nanowire Sensor based Assay for Detecting Dengue and Chikungunya Virus

    SBC: Innosense Llc            Topic: NIAID

    PROJECT SUMMARY The Dengue DENV and Chikungunya viruses CHIKV are primarily transmitted by two types of mosquitoes the Aedes aegypti and the Aedes albopictus Patients infected by DENV may experience dengue fever dengue hemorrhagic fever DHF and dengue shock syndrome DSS DHF and DSS could be fatal and are of particular public health concern in endemic regions of the U S Africa Asia ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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