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Rabies is a deadly zoonotic disease caused by rabies virusRABVand other lyssavirusesAnnuallyrabies causes approximatelyhuman deaths worldwideThe only widely accepted diagnostic test is the direct fluorescent antibodyDFAtestWhile rapid and sensitivethe DFA test requires expensivehighquality reagents and equipmentalong with trained diagnosticiansThese factors present economic and logistical barriers ...

Generation of high-resolution 3D anatomic and dynamic images without exposing patients to ionizing radiation renders MRI the preferred imaging modality for the detection of tumor extent and treatment response to neo-adjuvant and adjuvant medical therapies. The goal of this proposal is to develop a non-invasive, in vivo imaging-based platform that can repeatedly generate three-dimensional molecular ...

TBD

Project SummaryAbstract We envision developing a new ultrasensitive detection platform that combines a recombinant protein with a unique imaging media that results in a luminescent protein that is non bleaching and non blinkingThe excitation and emission wavelengths of this protein can be tuned with the choice of imaging media and span much of the visible and near infrared regions of the electroma ...

One of the most common and distressing symptoms of menopause are hot flashesHot flashes and related symptoms represent a significant unmetworldwidehealthcare neednot only in women after surgical or natural menopausebut also in breast and prostate cancer patients undergoing hormone suppression or ablationHot flashes occur inof women undergoing natural menopause and approximatelymillion individuals ...

Organ on a chip tools that recapitulate human biologyphysiology and pathology are urgently needed in applied science research and drug testing to expedite discoveries while reducing research costs and animal sacrificeUnfortunatelymost products incorporating circulation mimicking perfusion are too complicated for researchers to useincompatible with many protocols and readsand low throughputOur goal ...

KDH Research andampCommunicationKDHRCsubmits this Fast Track SBIR proposal to developimplementand rigorously evaluate a culturally competentonline professional development course to prepare promotores to support low income Latino parents of children with special health care needsCSHCNas they navigate the education and health care systemsCSHCN experience poorer healthpsychosocialand academic outcom ...

Program Director Principal InvestigatorLastFirstMiddleSloweyPaul DAbstract This phase I NIH SBIR proposal seeks support for an interdisciplinary partnership between Oasis Diagnosticsand Iowa State University who collaboratively seek to develop a novel tool that can measure and quantify levels of the sex hormone testosterone in saliva within minutes of collectionVerOFytestosteroneThe FDA has urged ...

PROJECT SUMMARY The objective of this SBIR Phase I application is to select an optimized lead analog ofconotoxin RgIA to develop as a uniquenon opioid therapeutic for chronic neuropathic painRgIAa peptide derived from the predatory marine cone snail Conus regiusis an inhibitor of thenicotinic acetylcholine receptornAChRa novel genetically validated pain targetOur current lead candidateKCPpotently ...

PROJECT SUMMARY Glycans have several distinct properties that make them potential disease biomarkers. Firstly, their location on cell surfaces makes them the first point of contact for cellular interactions, and thus they are crucial in the control of normal metabolic processes. Secondly, cell surface molecules are strategically exposed for surveillance by the immune system, where they may serve a ...