Award Data

Techulon has developed a platform based on peptide-peptide nucleic acids (PPNAs) molecules that are effective as antimicrobial compounds against multi-drug reisistant pathogens. Techulons targeted approach uses informatic algorithms applied towards an organisms genome to identify targets that will disrupt essential biological functions. The proposed Phase I project will focus on developing a new g ...

TDAs proposes to develop a novel RF heating process for rewarming cryogenically preserved tissues and organs. TDAs approach is to optimize the RF frequency and power, along with the chemical composition, size and morphology of infused nanoparticles so that they heat tissue samples rapidly and uniformly. In this manner, the cryoprotectant solutions pass from the vitrified state to the liquid stat ...

Combat medics can quickly be overcome with the variety and number of injuries received by fellow warfighters. Virtual Interactive Presence and Augmented Reality (VIPAR) systems already in place have shown great potential in alleviating these problems, but require too many prerequisites to use in the field. Expensive and specialized pieces of hardware are an additional strain on warfighters, and of ...

CPSI Biotech personnel have developed solutions and devices for the cryopreservation and hypothermic storage of human cells and tissues. Devices being -tested include SmartFreeze and SmartThaw - instruments designed for the improved cryopreservation and thawing of stem cells to be used for stem cell therapy. This SBIR grant application proposes to identify pre-conditioning and post-conditioning ...

The use of the Walter Reed National Military Medical Center (WRNMMC) can be difficult for patients and visitors to use due to the size and complexity of the facility. The current a kiosk concierge system cannot offer turn-by-turn facility navigation. This proposal seeks to design a combined indoor/outdoor navigation service to aid using and locating services and people in the WRNMMC facility. ...

Traumatic injuries to the head and neck region comprise as much as 30 percent of all combat injuries observed today. These injuries often involve multiple tissues including dermal, muscle, cartilage and bone. This work aims to address this critical need by treating a composite tissue injury model in the ear. We will use an alginate microbead cell delivery system

Major organ injuries such as liver, kidney, heart and lung injuries can lead to high morbidity and mortality in critically ill patients. Advanced noninvasive testing with high sensitivity and specificity is needed to detect specific organ injury particularly at early stages. Current techniques such as PCR, MS, absorption-based assays, ELISA and microfluidic-Luminex, cannot meet such requirements. ...

HemoSonics LLC is developing an easy to use and easy to interpret diagnostic device to rapidly identify diffuse coagulopathies in order to guide proper and evidence-based interventions. The management of diffuse coagulopathies is extremely important in military medicine as these conditions represent a significant source of combat morbidity and mortality. HemoSonics device is based on sonorheome ...

Not Available

This SBIR Program is to complete the development of a novel metalloporphyrin antioxidant compound BMX to be used as a radioprotector in the treatment of patients with head and neck cancer undergoing radiation therapy This drug product has been produced to GMP quality safety toxicology completed in one species and a high degree of efficacy demonstrated for both protecting against radiation ...