Award Data

Techulon has developed a platform based on peptide-peptide nucleic acids (PPNAs) molecules that are effective as antimicrobial compounds against multi-drug reisistant pathogens. Techulons targeted approach uses informatic algorithms applied towards an organisms genome to identify targets that will disrupt essential biological functions. The proposed Phase I project will focus on developing a new g ...

TDAs proposes to develop a novel RF heating process for rewarming cryogenically preserved tissues and organs. TDAs approach is to optimize the RF frequency and power, along with the chemical composition, size and morphology of infused nanoparticles so that they heat tissue samples rapidly and uniformly. In this manner, the cryoprotectant solutions pass from the vitrified state to the liquid stat ...

Lyme disease is a vector-borne illness caused by infection with B. burgdorferi. Hard ticks (Ixodes spp.) acquire the spirochete from a natural reservoir of small mammals; transmission to humans occurs via the bite of an infected tick. By any measure, Lyme disease is one of the most serious emerging infectious diseases that threaten public health in the United States. New estimates from the CDC ind ...

The use of the Walter Reed National Military Medical Center (WRNMMC) can be difficult for patients and visitors to use due to the size and complexity of the facility. The current a kiosk concierge system cannot offer turn-by-turn facility navigation. This proposal seeks to design a combined indoor/outdoor navigation service to aid using and locating services and people in the WRNMMC facility. ...

Traumatic injuries to the head and neck region comprise as much as 30 percent of all combat injuries observed today. These injuries often involve multiple tissues including dermal, muscle, cartilage and bone. This work aims to address this critical need by treating a composite tissue injury model in the ear. We will use an alginate microbead cell delivery system

Major organ injuries such as liver, kidney, heart and lung injuries can lead to high morbidity and mortality in critically ill patients. Advanced noninvasive testing with high sensitivity and specificity is needed to detect specific organ injury particularly at early stages. Current techniques such as PCR, MS, absorption-based assays, ELISA and microfluidic-Luminex, cannot meet such requirements. ...

HemoSonics LLC is developing an easy to use and easy to interpret diagnostic device to rapidly identify diffuse coagulopathies in order to guide proper and evidence-based interventions. The management of diffuse coagulopathies is extremely important in military medicine as these conditions represent a significant source of combat morbidity and mortality. HemoSonics device is based on sonorheome ...

In Topic DTRA143-001, a need has been identified to improve monitoring human presence near containers, stored items, and secured areas in order to monitor activities, particularly in remote locations that are not patrolled all day every day. The use of smart materials to detect human presence by sensing volatile organic compounds emanating from the human body is a major area of interest within the ...

The Defense Threat Reduction Agency (DTRA) has been supporting research of energetic materials and incendiaries as payloads for weapons to defeat targets containing chemical and biological agents. Several universities and Navy labs have been involved in this research, and have narrowed down on a few material formulations that are efficient biocides. These formulations contain a chemical ingredient ...

With missions surrounding counterproliferation, nonproliferation and WMD reduction, the stakes for DTRA are incredibly high. Effectively conducting this work involves cooperation and coordination across a wide range of military and government organizations throughout the United States and the world. The decentralization of threats has led to an explosion in the sources and types of data needed to ...