Award Data

The objective of this project is to develop, produce, and commercialize a liquid-tight, field-applicable, ocular patch for wound stabilization and treatment of the eye following a war-related injury to the ocular surface. The patch consists of a curved flexible silicone membrane (similar in size and shape to a contact lens) which has had (1) a novel bio-adhesive

Currently, no commercial products exist for the repair of large injuries to muscle, particularly volumetric muscle loss (VML). In Phase I of this project, data demonstrated that keratin biomaterials can provide temporal release of growth factors while maintaining cell viability in vitro and in vivo. In Phase II, the biomaterial formulation was optimized for spatio-temporal delivery of cells and gr ...

Traumatic injuries to the head and neck region comprise as much as 30 percent of all combat injuries observed today. These injuries often involve multiple tissues including dermal, muscle, cartilage and bone. This work aims to address this critical need by treating a composite tissue injury model in the ear. We will use an alginate microbead cell delivery system

Major organ injuries such as liver, kidney, heart and lung injuries can lead to high morbidity and mortality in critically ill patients. Advanced noninvasive testing with high sensitivity and specificity is needed to detect specific organ injury particularly at early stages. Current techniques such as PCR, MS, absorption-based assays, ELISA and microfluidic-Luminex, cannot meet such requirements. ...

HemoSonics LLC is developing an easy to use and easy to interpret diagnostic device to rapidly identify diffuse coagulopathies in order to guide proper and evidence-based interventions. The management of diffuse coagulopathies is extremely important in military medicine as these conditions represent a significant source of combat morbidity and mortality. HemoSonics device is based on sonorheome ...

Burn injuries, particularly those to the face, present a number of functional and psychological challenges that arise from scarring and related contracture. A major goal of trauma and burn surgeons is to prevent scarring and improve grafting technologies given the complexity of facial topography. This project seeks to optimize and finalize a prototype of a 3D printed keratin facemask capable of ...

PsiKick and Bionic Skins LLC will collaborate in this proposal to develop the eBionicskins system, an advanced instrumented prosthetic liner for monitoring the tissue interface within a prosthetic socket using a wireless sensing platform. PsiKicks ultra-low power electronics fit neatly within Bionic Skins vision for a complete redesign of prosthetic sockets with a variable-compliant interface tha ...

Military personnel must be protected from diseases transmitted by ticks and fleas, including Lyme disease. Effective surveillance of tick and flea vectors is vital to determine the population present, whether they are carrying disease, and whether control campaigns are working. Unfortunately, current surveillance tools are ineffective. In Phase I TDA designed, prototyped, and tested a novel ti ...