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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Activating latent growth factors for cartilage regeneration


    Project summary Articular cartilage lesions are prevalent disorders affecting millions of AmericansDeprived of spontaneous healing capacitycartilage lesions may further deteriorate and lead to the onset of osteoarthritisOAOA represents a leading cause of chronic disabilities in the U Sand ultimately warrants total joint arthroplastyA common aspiration in orthopedic medicine is to regenerate the da ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A High-Throughput, Multi-Omic Assay of Tumor Biomarkers from Single-Cells

    SBC: IsoPlexis            Topic: 172

    SUMMARY Although solid tumors oftentimes arise from the uninhibited growth of a single aberrant cellthe population of cells within a tumor are genetically and molecularly heterogenousThis makes it very difficult to evaluate a therapy s efficacy when using bulk population measurementsFurthermorerecent research has implicated microRNAsmiRNAsas drivers of progression and malignancy in many tumor type ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Development of Non-Stigmatizing Hip Protection for Prevention of Fall-Related Injuries

    SBC: Alba-Technic, LLC            Topic: NIA

    PROJECT SUMMARY ABSTRACT Hip fracture is one of the most serious fall related injuries in older adultshas a high rate of mortality and higher rate of disabilityThe incidence of hip fractures continues to increase as older adults become a larger proportion of the U SpopulationWithin one year post hip injuryof elderly die andof community dwellers are placed in nursing homesAccordinglyhip injury prev ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. New Techniques for Real-Time Microsleep Assessment


    SUMMARY SignificanceImpaired alertness accompanied by short microsleep events is a frequently reported phenomenon in all areas of modem lifeA microsleep event can be defined as a somewhat unexpected short episode of sleepbetweenandsecondsthat occurs in the midst of ongoing wakeful activityPeople who experience microsleeps usually remain unaware of theminstead believing themselves to have been awak ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Restoring Beta-lactam efficacy against methicillin-resistant Staphylococci

    SBC: Prokaryotics, Inc.            Topic: NIAID

    Methicillin resistant Staphylococcus aureusMRSAand methicillin resistant Staphylococcus epidermidisMRSEare a major cause of bloodstream infections in the hospital and in the communityIndeedMRSA remains the second leading cause of mortality by drug resistant bacterial pathogens in the USAAlthough two mechanistically novel antibiotic classes exist to treat such infectionsDaptomycinDAP and LinezolidL ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Preparation and development of a stabilized C3 analog for the treatment of paroxysmal nocturnal hemoglobinemia

    SBC: Cascade Biotechnology            Topic: NHLBI

    Abstract We propose to develop analogs of human complement Cthat have the ability to form a stable CconvertaseIn additionthese proteins will be designed to decrease the affinity of the proteins for factor H bindingAll proteins will be expressed in the Baculovirus insect protein expression systemand tested for their ability to form a stable Cconvertase enzyme that is able to deplete complement in h ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Antepartum tactile imager for minimizing risk of maternal childbirth trauma

    SBC: Advanced Tactile Imaging, Inc.            Topic: NICHD

    Overof women suffer obstetric trauma to one or several components of the pelvic floorwith vaginaperineal bodylevator ani musclesand the anal sphincter complex affected most commonlyBirth injury to these integral structural components of the female pelvic floor leads to pelvic pain and dyspareuniaand serves as the most important and potentially modifiable risk factor for subsequent pelvic floor dis ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. pRBC Contaminant Removal with Hemocompatible Porous Polymer Beads

    SBC: CytoSorbents Medical Inc.            Topic: NHLBI

    Packed red blood cellpRBCtransfusions save livesHoweverhundreds of thousands of non hemolytic transfusion reactions occur each year worldwideranging from mild fever and pruritisto serious lifethreatening reactions such as severe hyperkalemiaanaphylaxisand transfusion related acute lung injuryTRALIMild moderate reactions drive patient discomfortdocumentationand testing costs while serious reactions ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Oral-ERT of Pompe Disease with Tobacco Seed-Derived Recombinant Acid Maltase

    SBC: JME Group            Topic: NIAMS

    Genetic deficiency of lysosomal acid maltase or acid alpha glucosidaseGAAresults in the orphan disease glycogen storage disease type IIGSDIIacid maltase deficiency or Pompeandapos s diseasePDencompassing at least five clinical subtypes of varying severityThe current approved enzyme replacement therapyERTfor PD is via intravenous infusion of a recombinant human GAArhGAAproduced by CHO cellsMyozymeG ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Adenylyl Cyclase Type 5 Inhibition to Treat Myocardial Infarction


    PROJECT SUMMARY ABSTRACT The most significant advance in the treatment of Myocardial InfarctionMIhas been reperfusion therapywhich must be applied immediately after the MI diagnosis has been madeDespite the thousands of studies on drug therapies designed to reduce the size of the MImost have failed in clinical trialsOur hypothesis is that a major reason why these drugs failed is that they must be ...

    SBIR Phase I 2018 Department of Health and Human Services

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