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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A High-Throughput, Multi-Omic Assay of Tumor Biomarkers from Single-Cells

    SBC: IsoPlexis            Topic: 172

    SUMMARY Although solid tumors oftentimes arise from the uninhibited growth of a single aberrant cellthe population of cells within a tumor are genetically and molecularly heterogenousThis makes it very difficult to evaluate a therapy s efficacy when using bulk population measurementsFurthermorerecent research has implicated microRNAsmiRNAsas drivers of progression and malignancy in many tumor type ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Development of Non-Stigmatizing Hip Protection for Prevention of Fall-Related Injuries

    SBC: Alba-Technic, LLC            Topic: NIA

    PROJECT SUMMARY ABSTRACT Hip fracture is one of the most serious fall related injuries in older adultshas a high rate of mortality and higher rate of disabilityThe incidence of hip fractures continues to increase as older adults become a larger proportion of the U SpopulationWithin one year post hip injuryof elderly die andof community dwellers are placed in nursing homesAccordinglyhip injury prev ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. New Techniques for Real-Time Microsleep Assessment


    SUMMARY SignificanceImpaired alertness accompanied by short microsleep events is a frequently reported phenomenon in all areas of modem lifeA microsleep event can be defined as a somewhat unexpected short episode of sleepbetweenandsecondsthat occurs in the midst of ongoing wakeful activityPeople who experience microsleeps usually remain unaware of theminstead believing themselves to have been awak ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Development of Ryan Companion Robot for Assisting Elderly People with Alzheimer's Disease

    SBC: Dream Face Technologies, LLC            Topic: NIA

    The objective of the proposed Fast Track SBIR effort is to develop and commercialize the Ryan CompanionBothereafterRyanan intelligent conversational life like social robotdesigned to improve the well being and quality of life of older adults with early stage Alzheimerandapos s diseaseADand AD Related DementiaADRDAccording to the NIAresearch reports estimate that as many asmillion Americans may hav ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Development of a scalable, portable fMRI-validated device platform for acute musculoskeletal pain.

    SBC: WAVi Co.            Topic: NIDA

    Pain assessment is a pressing clinical problem in need of better measurement toolsProposedsolutions include electroencephalography and event related potentialsEEG ERPautonomic measuressuch as heart rate and heart rate variabilityand analysis of facial expressionsAll of thesepromising modalities could potentially combine into one streamlined test by establishing theprotocols that give the highest i ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Peripheral FAAH inhibitor, URB937, as an opioid-sparing analgesic for chronic pain.

    SBC: AspireBio Corp            Topic: 101

    PROJECT SUMMARY Opioid drugs are powerful analgesicsbut their side effect profile strongly limits their useIndeedtheir addictive properties have led to an epidemic of abuse in the US that accounts forof the global utilization of prescription opioid analgesics in the USwith a market of over $billion per yearPrevious studies have shown that the endocannabinoid neurotransmitteranandamidecontrols noci ...

    STTR Phase I 2018 Department of Health and Human Services
  7. Quantitative Biotherapeutic Particle Characterization via Deep Neural Networks

    SBC: Ursa Analytics            Topic: 400

    Project SummaryDespite their many bene ts and common useprotein based drugs can elicit serious adverse side effectsMany of these side effects are believed to be caused by small protein aggregatesOne tool for measuring these particles in a high throughput fashion is Micro ow ImagingMFIMFI is commonly used in both academia and industry to characterize subvisible particlesthosem in sizein protein the ...

    STTR Phase I 2018 Department of Health and Human Services
  8. DT-EGF Toxic Fusion Protein for the Treatment of Bladder Cancer

    SBC: Aurora Oncology, Inc.            Topic: 399

    Project Summary Abstract Bladder cancer causes overannual deaths worldwide withnew cases anddeaths reported in the USTreatment of superficial bladder cancer by resection and BCG administration is unsuccessful inof cases with recurrences eventually requiring cystectomy or other aggressive therapynew therapies are neededThe role of Epidermal Growth Factor ReceptorEGFRin bladder cancer pathogenesis h ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Family Therapy Training and Implementation Platform (FTTIP): An innovative web-based tool for long-term practice improvement

    SBC: Santisteban, David            Topic: 104

    Project Summary AbstractFamily therapy has emerged as one of the most efficacious interventions for child and adolescent behavioral and psychiatric issues such a Conduct Disorder and Substance Use Disorders and for chronic health conditions such as cancer and Alzheimer sHoweverwidespread implementation of family therapy is often hampered by high training costsre training needs following staff turn ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Automated Real-Time Trauma Resuscitation Communication System for Clinical Decision Support

    SBC: Lifeboard Medical            Topic: NLM

    PROJECT SUMMARY Despite rapid transport to appropriate facilitiesmany trauma patients needlessly die in the first hour of careTrauma is the leading cause of death for Americans under the age ofand greatest cause of potential life years lost before the age ofexceeding that of either cancer or heart diseaseUp toof traumatic deaths may be preventableIt is estimated that miscommunication is the leadin ...

    SBIR Phase I 2018 Department of Health and Human Services

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