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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A High-Throughput, Multi-Omic Assay of Tumor Biomarkers from Single-Cells

    SBC: IsoPlexis            Topic: 172

    SUMMARY Although solid tumors oftentimes arise from the uninhibited growth of a single aberrant cellthe population of cells within a tumor are genetically and molecularly heterogenousThis makes it very difficult to evaluate a therapy s efficacy when using bulk population measurementsFurthermorerecent research has implicated microRNAsmiRNAsas drivers of progression and malignancy in many tumor type ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Development of Non-Stigmatizing Hip Protection for Prevention of Fall-Related Injuries

    SBC: Alba-Technic, LLC            Topic: NIA

    PROJECT SUMMARY ABSTRACT Hip fracture is one of the most serious fall related injuries in older adultshas a high rate of mortality and higher rate of disabilityThe incidence of hip fractures continues to increase as older adults become a larger proportion of the U SpopulationWithin one year post hip injuryof elderly die andof community dwellers are placed in nursing homesAccordinglyhip injury prev ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. New Techniques for Real-Time Microsleep Assessment

    SBC: VERIFAX CORPORATION            Topic: NCCDPHP

    SUMMARY SignificanceImpaired alertness accompanied by short microsleep events is a frequently reported phenomenon in all areas of modem lifeA microsleep event can be defined as a somewhat unexpected short episode of sleepbetweenandsecondsthat occurs in the midst of ongoing wakeful activityPeople who experience microsleeps usually remain unaware of theminstead believing themselves to have been awak ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Development of a Clinical Screening Platform for Type 1 Diabetes

    SBC: Op-T-Mune, Inc            Topic: NIDDK

    AbstractA major shortfall in clinical care for diabetes is a rapid and accurate screen for progression to diseaseCurrent criteria involve HLA haplotypeand the presence of auto antibodiesAAGenome wide associated studiesGWASrevealed only immune associated genes including HLA as T D predictorsThe ability to differentiate from other diseases was very limitedPre typediabetesp T Dis now being identified ...

    STTR Phase II 2018 Department of Health and Human Services
  5. Development of Ryan Companion Robot for Assisting Elderly People with Alzheimer's Disease

    SBC: Dream Face Technologies, LLC            Topic: NIA

    The objective of the proposed Fast Track SBIR effort is to develop and commercialize the Ryan CompanionBothereafterRyanan intelligent conversational life like social robotdesigned to improve the well being and quality of life of older adults with early stage Alzheimerandapos s diseaseADand AD Related DementiaADRDAccording to the NIAresearch reports estimate that as many asmillion Americans may hav ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Caminamos: A location-based Smartphone App for Latinas to Connect with Nearby Walking Partners

    SBC: KLEIN BUENDEL, INC            Topic: 102

    Health disparities are high among LatinasThey are more likely to be overweightdiagnosed with diabetesand physically inactive compared to their non Hispanic White counterpartsThusinterventions that target improving health access and ameliorating chronic diseases among Latinas are of high public health importanceAvailable data suggest that community focused interventions produce improvements in phys ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. Development of a scalable, portable fMRI-validated device platform for acute musculoskeletal pain.

    SBC: WAVi Co.            Topic: NIDA

    Pain assessment is a pressing clinical problem in need of better measurement toolsProposedsolutions include electroencephalography and event related potentialsEEG ERPautonomic measuressuch as heart rate and heart rate variabilityand analysis of facial expressionsAll of thesepromising modalities could potentially combine into one streamlined test by establishing theprotocols that give the highest i ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Peripheral FAAH inhibitor, URB937, as an opioid-sparing analgesic for chronic pain.

    SBC: AspireBio Corp            Topic: 101

    PROJECT SUMMARY Opioid drugs are powerful analgesicsbut their side effect profile strongly limits their useIndeedtheir addictive properties have led to an epidemic of abuse in the US that accounts forof the global utilization of prescription opioid analgesics in the USwith a market of over $billion per yearPrevious studies have shown that the endocannabinoid neurotransmitteranandamidecontrols noci ...

    STTR Phase I 2018 Department of Health and Human Services
  9. Proprietary biologic treatment to heal skin wounds

    SBC: Allander Biotechnologies            Topic: NIDCR

    SUMMARY Chronic skin wounds associated with various diseasese gdiabetesand aberrant healing from acute woundinge ghypertrophic scarringare a major health care burdenThis health burden increases in aging populationsThe cost to treat these conditions exceeds $billion annuallyCurrentlyREGRANEXa cream containing a biologic based on human PDGFPlatelet Derived Growth Factoris the only FDAFood and Drug A ...

    SBIR Phase II 2018 Department of Health and Human Services
  10. Quantitative Biotherapeutic Particle Characterization via Deep Neural Networks

    SBC: Ursa Analytics            Topic: 400

    Project SummaryDespite their many bene ts and common useprotein based drugs can elicit serious adverse side effectsMany of these side effects are believed to be caused by small protein aggregatesOne tool for measuring these particles in a high throughput fashion is Micro ow ImagingMFIMFI is commonly used in both academia and industry to characterize subvisible particlesthosem in sizein protein the ...

    STTR Phase I 2018 Department of Health and Human Services

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