Award Data

DESCRIPTION (provided by applicant): Malignancies of the brain are among the most devastating diseases known. Glioblastoma multiform (GBM) in particular are known for their rapid, uncontrolled, and aggressive growth. Very little progress has been made in the treatment of GBM over the past 25 years. A more recent promising therapeutic approach is convection enhanced delivery (CED) in which chemothe ...

DESCRIPTION (provided by applicant): Where arm functioning has been compromised due to a stroke, brain injury, or other neurological injury and rehabilitative progress is to be obtained in the upper extremity, it is crucial to limit over-stretching of theshoulder joint (attributed to lost muscle tone) and to control pain. Medeon, LLC is actively working with rehabilitation experts to develop the ...

DESCRIPTION (provided by applicant): Among amputation types involving the upper limbs, partial hand is the most prevalent by far and among the most challenging for prosthetists to address well. Sound side overreliance for these amputees gives rise to a high prevalence of contralateral overuse syndrome (COS), a progressive, painful, and debilitating condition. Research shows that prostheses reduce ...

DESCRIPTION (provided by applicant): Introduction of small interfering RNAs (siRNAs) into cells with transfection reagents results in efficient gene silencing. Unfortunately, while siRNA-based functional genomics is widely used in vitro, the ability to apply this technology to primary cells and in vivo target validation has been impeded limited availability of efficient and non-toxic delivery syst ...

DESCRIPTION (provided by applicant): In this Phase I SBIR project, TDA Research, Inc. will develop a compact, lightweight portable oxygen concentrator (POC) for medical operations and carry out a breadboard demonstration to produce continuous flow of enriched oxygen (O2) from ambient air. The new POC will weigh less than 10 lbs including the rechargeable batteries that will provide a minimum of 10 ...

DESCRIPTION (provided by applicant): It is a rare event when new and useful medical parameters can be added to the suite of monitoring and diagnostic tests available in a clinical setting. Of particular importance is the ability to measure crucial physiological parameters or analytes in a continuous and noninvasive manner-evidenced by the importance of noninvasive vital signs monitoring-because it ...

DESCRIPTION (provided by applicant): Ventilator-associated pneumonia (VAP) is the most costly and second most common hospital-acquired infection (HAI), accounting for over 86% of hospital-acquired pneumonia (HAP). Some 300,000 HAP patients are treated annually in the U.S., at an estimated annual hospital cost of more than 1.5 billion. The current paradigm for preventing VAP has been to implement ...

DESCRIPTION (provided by applicant): As the well known baby boomer generation surges toward retirement age, the issue becomes more significant each day of how this generation of 78 million seniors will be able to remain as independent as possible while increasingly burdened by the onset of multiple, chronic, medical conditions and a decline in cognitive abilities. Concurrent with the dramatic incr ...

DESCRIPTION (provided by applicant): Patients treated with antibiotics frequently develop diarrhea. In developed countries, adults, particularly the elderly, experience a higher death rate due to diarrhea than children. Results from in vitro and preliminary in vivo studies lead us to hypothesize that oral administration of recombinant human lactoferrin as a medical food might be able to prevent an ...

DESCRIPTION (provided by applicant): The objective for this Phase II application is to develop a cartridge-based automated molecular diagnostic platform to rapidly and cost-effectively detect and identify influenza viruses. The system will automate all keyfunctions for sample processing including extraction, amplification, colorimetric detection on a low- density microarray, and image/result inter ...