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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Sorbents for Toxic-Metal Removal in Pharmaceutical Development and Manufacture

    SBC: TDA Research, Inc.            Topic: FDA

    DESCRIPTION: The overall project goal is to develop sorbents that remove catalytic metals used in drug synthesis, which if not adequately removed between synthetic steps and from the final active pharmaceutical ingredients, can lead to toxic side-effects.Sorbents are being designed to meet new U.S. Pharmacopeia and international standards to be implemented in September, 2013. Goals are to remove c ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Low Cost Laser Diagnostic for CD4+ T Cell Counting

    SBC: Mbio Diagnostics, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): The overall goal of this project is to develop and commercialize a simple cell counter for routine enumeration of CD4 cells for management of HIV-infected individuals. HIV-1 mediated CD4 cell destruction is the centralimmunologic feature of HIV-1 infection. Thus, the CD4 count is a critical measurement in initial disease staging, in monitoring antiretroviral t ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. A new, rapidly dissolving and thermally stable dry powder Hepatitis-B vaccine

    SBC: AKTIV-DRY            Topic: NIAID

    DESCRIPTION (provided by applicant): The overarching goal of this project is to move a new, dry powder formulation of Hepatitis-B vaccine on its path to commercialization. In the Phase I SBIR we tested in vitro three Hep-B dry powder formulations of commercially available Shanvac-B and demonstrated powder stability and immunogenicity at temperatures ranging from -20 ?C through 65 oC. At these temp ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Development of a Novel PolC Inhibitor as a Gram-Positive Antibiotic

    SBC: CRESTONE, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The alarming increase in incidence of infections caused by drug-resistant bacteria has created an urgent need for new antibacterial agents. We are developing a novel class of small molecule antibiotics ( TZUs ) targeting PolC, the replicative DNA polymerase in Gram-positive bacteria. These agents exhibit broad-spectrum activity against Gram-positive bacteria, ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Robust, defined, animal-free cell culture medium for the production of vaccines


    DESCRIPTION (provided by applicant): The Vero cell line is used in the production of viral based vaccines. The use of cell based vaccines based on the Vero cell line is growing. The majority of the vaccines in use today are produced using cell culture medium supplemented with serum. The use of animal-derived products in vaccine culture media presents a risk for the transmission of infectious disea ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. A Patient Centered Approach to Enrolling Rare Cancer Patients in Clinical Trials

    SBC: PHARMATECH, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): The American Cancer Society estimates that more than 1.5 million new cancer victims will be diagnosed this year in the U.S., and that ~572,000 Americans will die of cancer in 2011.1 More than 13 million Americans are living today with a history of cancer, and this number is heading toward 18 million by 2020.1 Beyond the human costs in lives, productivity, and q ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. Footwear-based physical activity biofeedback device for weight management


    DESCRIPTION (provided by applicant): The number of adults and children who are overweight or obese continues to increase and has reached epidemic proportions. Obesity is due to a sustained positive energy balance (energy intake gt energy expenditure) and is typically coupled with low levels of physical activity (i.e. sedentary lifestyles). The combination of obesit and inactivity has resulted in i ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Beating-Heart Surgery for Heart Valve Replacement

    SBC: VALVEXCHANGE, INC.            Topic: NHLBI

    Each year, over 115,000 patients in the US need to have their diseased heart valves replaced with artificial devices. Although bioprosthetic valves are considered ideal, they wear out in about 15 years and are thus used primarily in the elderly who are notexpected to outlive the valve. Younger patients receive mechanical valves that are more durable, but require chronic anticoagulation. This makes ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. Human Lactoferrin in Acetaminophen Overdose-Induced Liver Failure


    DESCRIPTION (provided by applicant): An acute or cumulative overdose of acetaminophen (APAP), following either therapeutic overdose or suicide attempts, can cause severe liver damage with the potential to progress to liver failure. APAP overdose accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure each year, making APAP ...

    STTR Phase I 2012 Department of Health and Human Services
  10. A novel 3D microscope for imaging and photostimulation

    SBC: Boulder Nonlinear Systems, Inc.            Topic: NIMH

    DESCRIPTION (provided by applicant): Mental disease, including schizophrenia, depression and autism spectrum disorders, are still poorly understood, although it is clear that they mostly represent cortical disorders. The cortex is the primary site of higher mental functions, and despite extensive research, there is still no unified theory of how the cortex works. This is partl due to the fact that ...

    STTR Phase I 2012 Department of Health and Human Services

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