Award Data

DESCRIPTION: Surveys conducted by municipal wastewater treatment plants across the country have concluded that anywhere from 10 percent to over 70 percent of the mercury reaching the plants comes from Dental offices. These findings, combined with increasingly stringent regulations on mercury discharges, have placed pressure on the Dental profession to reduce their dis ...

DESCRIPTION: The goal of this new SBIR application is to develop an economical Dental waterline that resists biofilm formation and growth. The proposed waterline will utilize a photocatalytic oxidation system to inhibit microbial growth. Such a system would obviate the need for extraneous chemicals and would allow continuous cleansing of the waterlines. The photoreact ...

DESCRIPTION (Adapted from the Investigator's Abstract): The chlorofluorocarbon (CFC) propellants currently being used in metered dose inhalers for pulmonary drug delivery are being phased out due to their high ozone depletion potential. An international pharmaceutical industry consortium has proposed that the zero-ozone depletion potential hydrofluoroalkane (HFA) propel ...

This Phase I and II SBIR will develop a user-friendly, run-time efficient software package dedicated to fitting and evaluating material models used in finite element codes like LS-DYNA. The software package will consist of a pre-processor, a core driver, and a post-processor. The pre-processor will allow the user to specify the material model, model parameters, and desired load history. The dri ...

DESCRIPTION (provided by applicant): Affinity tag technology has become increasingly important for immobilizing proteins for high-throughput screening, for generating protein arrays, and for simplifying protein purification. There is a pressing need for economical and technically simple technologies to immobilize or purify proteins. None of the existing molecula ...

DESCRIPTION: (Investigator's abstract) Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is a cytokine that stimulates proliferation and differentiation of hematopoietic progenitor cells. Recombinant human GM-CSF is used to stimulate neutrophil production in patients with neutropenia resulting from myelosuppressive chemotherapy. Recombinant human GMCSF ...

DESCRIPTION: (Investigator's abstract) Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is a cytokine that stimulates proliferation and differentiation of hematopoietic progenitor cells. Recombinant human GM-CSF is used to stimulate neutrophil production in patients with neutropenia resulting from myelosuppressive chemotherapy. Recombinant human GMCSF ...

DESCRIPTION: This is a Phase II grant application to further develop long acting G-CSF proteins for the treatment of neutropenia. It is submitted by Bolder Biotechnology, Inc. George N. Cox, PhD, Principal investigator. The investigator notes the recombinant G-CSF has a worldwide ...

DESCRIPTION: This is a Phase II grant application to further develop long acting G-CSF proteins for the treatment of neutropenia. It is submitted by Bolder Biotechnology, Inc. George N. Cox, PhD, Principal investigator. The investigator notes the recombinant G-CSF has a worldwide ...

Beta-interferon is a fibroblast-derived cytokine that exhibits antiviral, antiproliferative and immunomodulatory effects on many cell types. Recombinant human beta-interferon has proven effective in treating Multiple Sclerosis and had worldwide sales of $850 million during 1998. We propose to create modified beta-interferon proteins that can be administered less frequently, but with greater effica ...