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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. TOPIC 356: FLOUROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

    SBC: Lucerna Inc.            Topic: NCI

    Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 374: Topical Delivery of Nanoformulated Bioactive Chemopreventive Agent in Skin Cancer

    SBC: VASCULAR VISION PHARMACEUTICAL CO            Topic: NCI

    We plan to evaluate the chemopreventive management of solar ultraviolet (UV) mediated DNA damage by two different Nanoformulation of epigallicatechin-3-gallate (EGCG). The formulations to be assessed under this study include: a) chitosan based formulation of EGCG (nano-EGCG), and b) EGCG containing chitosan based solid lipid nanoparticles (E-Ch-SLNPs). EGCG is well-tested and popular polyphenol in ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 341: Open Scalable Software Infrastructure for Metabolomics Data

    SBC: Kitware, Inc.            Topic: NCI

    Metabolomics research has great potential, and researchers are rapidly producing new techniques for analyzing the large quantities of measurement data in order to utilize metabolomic data more effectively, including promising techniques for data integration across multiple modalities of data from mass spectrometry (MS) and nuclear magnetic resonance (NMR). However, this confluence of data growth a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. New and Innovative Overhead Persistent InfraRed (OPIR) Sensor Tasking Capabilities

    SBC: BLACK RIVER SYSTEMS COMPANY INC            Topic: MDA13007

    Our objective is to develop and demonstrate an integrated capability to perform dynamic retasking of enterprise wide management of OPIR, radar, and other operationally relevant sensors. The goals of this effort are to refine our existing OPIR tasking approach and to develop and Enterprise SRM approach that will allow the C2BMC to achieve the earliest possible launch detection and maintain the high ...

    SBIR Phase II 2018 Department of DefenseMissile Defense Agency
  5. Configurable Link Test Set (CoLTS) Jamming Capability

    SBC: WELKIN SCIENCES, LLC            Topic: MDA10003

    Under this Phase II SBIR effort Welkin Sciences will design and implement a Jammer Emulator hosted on the MDA sponsored CoLTS-LC hardware platform, originally built for nuclear-effects channel simulation.The Jammer Emulator will support emulation of a wide range of jamming methods, including frequency-following, which is not readily implemented using standard commercial test equipment.A remote int ...

    SBIR Phase II 2018 Department of DefenseMissile Defense Agency
  6. LG Technology Innovative Research, Streamlining Scenario Generation Across a System of Systems Simulation Enterprise

    SBC: STILMAN ADVANCED STRATEGIES, LLC            Topic: MDA16006

    To enhance Operational Test (OT) fidelity, increase automation, and shorten the testing process, the Missile Defense Agency (MDA) seeks innovative research efforts to develop scenario generation technologies. STILMAN proposes to conduct novel research to develop a highly automated and composable scenario generation toolset. Currently, in the distributed system of systems Operational Testing enterp ...

    SBIR Phase II 2018 Department of DefenseMissile Defense Agency
  7. Advanced Rocket Trajectory Propagation Techniques

    SBC: RESERVOIR LABS INC            Topic: MDA17T002

    Reservoir Labs and Johns Hopkins University will develop alternative numerical solution techniques that improve computational loading, data storage, and data integrity for rocket vehicle trajectory modeling in MDA federated simulations.The objective of this program is to develop new techniques for trajectory propagation that are more suited for use in federated simulations than traditional methods ...

    STTR Phase I 2018 Department of DefenseMissile Defense Agency
  8. Simultaneous Multiple Object Detection System

    SBC: SEMQUEST, INC.            Topic: MDA16T006

    An advanced hit detection technology is needed for MDA that can report impacts at hyper-velocities and at multiple hit locations.We present a technology with a high level of performance that leverages decades of hit technology experience and utilizes existing technologies developed under previous efforts.Our technology offers a low latency non-interpolated direct indicator of multiple hit location ...

    STTR Phase II 2018 Department of DefenseMissile Defense Agency
  9. Radar Cross Section Testing for Modeling and Simulations

    SBC: Andro Computational Solutions LLC            Topic: MDA17009

    The objective of the proposal is to conduct theoretical research and development related to the expedited radar cross section (RCS) testing to determine the merit and technical feasibility of proposed concept. In Phase I ANDRO/Alion team proposes adapting techniques drawn from real-time electronic warfare counter-measure systems, multi-threat response and characterization where direct use of short ...

    SBIR Phase I 2018 Department of DefenseMissile Defense Agency
  10. Techniques for Real-time Hypervelocity Projectile fly-out Generation and Optimization

    SBC: NUMERICA CORPORATION            Topic: MDA18002

    The Missile Defense Agency (MDA) faces the challenge of countering increasingly advanced missile threats.Hypervelocity projectiles (HVPs) offer the potential for highly effective and low-cost point defense against advanced missile threats. Efficient algorithms for HVP fly-out trajectory generation are needed, to provide real-time guidance from launch to intercept.These algorithms must react quickl ...

    SBIR Phase I 2018 Department of DefenseMissile Defense Agency

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