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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. TOPIC 356: FLOUROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

    SBC: Lucerna Inc.            Topic: NCI

    Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 374: Topical Delivery of Nanoformulated Bioactive Chemopreventive Agent in Skin Cancer

    SBC: VASCULAR VISION PHARMACEUTICAL CO            Topic: NCI

    We plan to evaluate the chemopreventive management of solar ultraviolet (UV) mediated DNA damage by two different Nanoformulation of epigallicatechin-3-gallate (EGCG). The formulations to be assessed under this study include: a) chitosan based formulation of EGCG (nano-EGCG), and b) EGCG containing chitosan based solid lipid nanoparticles (E-Ch-SLNPs). EGCG is well-tested and popular polyphenol in ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 377: Enabling Clinical Decision Support for Guideline Based Cancer Symptom Management

    SBC: KLESIS, LLC            Topic: NCI

    The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 341: Open Scalable Software Infrastructure for Metabolomics Data

    SBC: Kitware, Inc.            Topic: NCI

    Metabolomics research has great potential, and researchers are rapidly producing new techniques for analyzing the large quantities of measurement data in order to utilize metabolomic data more effectively, including promising techniques for data integration across multiple modalities of data from mass spectrometry (MS) and nuclear magnetic resonance (NMR). However, this confluence of data growth a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 374: Targeted and Sustained Release Microparticles for Colon Cancer Chemoprevention

    SBC: Zymeron Corporation            Topic: NCI

    Colorectal Cancer (CRC) is the third most common cancer both in men and women, as well as the second leading cause of cancer deaths with an estimated 135,430 new cases diagnosed and 50,260 deaths for 2017 in the United States. Given the limitations of screening tests and poor prognosis associated with advanced stage colorectal cancer, it would be of great interest in exploring chemoprevention stra ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. The objective of this contract is to develop an HIV latent reservoir assay using a microwell array consumable.

    SBC: Cell Microsystems, Inc.            Topic: NIAID

    A critical remaining challenge toward a true cure for HIV is understanding how latently infected cells evade the immune system and persist as lifelong viral reservoirsOne eradication strategythe so calledshock and killapproachrelies on cell activating compounds to reverse latent infectionand subsequent antiretroviral therapy to eradicate newly activated cellsHoweverthese compounds activate only a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. The purpose of this contract is to develop imprinted polymer resins for the purification of HIV envelope vaccine candidates

    SBC: Zymeron Corporation            Topic: NIAID

    There currently lack diagnostic tools with necessary sensitivity for use in the elimination and post elimination efforts for malaria and other Neglected Tropical DiseasesNTDsMicroscopy and rapid diagnostic testsRDTshave been largely adequate for malaria control and case management but lack the sensitivity to detect low density infectionsAsymptomatic individuals with chronic infection remain reserv ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Interference Detection and Analysis Device

    SBC: Andro Computational Solutions LLC            Topic: HSB0181003

    Law enforcement and public safety agencies rely on the 700 MHz/800 MHz spectrum band which are affected by co-channel interference from the commercial radio networks along with unintentional as well as intentional radio frequency interferers (RFIs). The first responders need to be alerted or have prior knowledge of potential interferences at a mission site. This will enable them to adopt strategie ...

    SBIR Phase I 2018 Department of Homeland Security
  9. Firmware Automated Analysis at Scale with Testing

    SBC: Red Balloon Security, Inc.            Topic: HSB0181008

    The firmware running on mobile, embedded, and Internet of things devices is often treated as a blackbox by organizations. These firmware images can contain a myriad of n-day vulnerabilities, both malicious and unintentional backdoors, and other unwanted functionality. Unfortunately, analyzing these firmware images is a difficult and time-consuming task as each firmware can be packed with layers of ...

    SBIR Phase I 2018 Department of Homeland Security
  10. Improved Human Systems for Computed TomographySpeed of Image Review

    SBC: IDSS Holdings, Inc.            Topic: HSB0181006

    IDSS in partnership with Tufts University Human Factors Engineering Program, a leader in Engineering Phycology, proposes to study CT screening system operator burden and reduce image review time by reviewing the GUI and the current man-machine interaction, perform a cognitive and behavioral analysis of the interaction, perform a time an motion study and recommend and perform limited prototyping of ...

    SBIR Phase I 2018 Department of Homeland Security

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