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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. TOPIC 356: FLOUROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

    SBC: Lucerna Inc.            Topic: NCI

    Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 374: Topical Delivery of Nanoformulated Bioactive Chemopreventive Agent in Skin Cancer

    SBC: VASCULAR VISION PHARMACEUTICAL CO            Topic: NCI

    We plan to evaluate the chemopreventive management of solar ultraviolet (UV) mediated DNA damage by two different Nanoformulation of epigallicatechin-3-gallate (EGCG). The formulations to be assessed under this study include: a) chitosan based formulation of EGCG (nano-EGCG), and b) EGCG containing chitosan based solid lipid nanoparticles (E-Ch-SLNPs). EGCG is well-tested and popular polyphenol in ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 377: Enabling Clinical Decision Support for Guideline Based Cancer Symptom Management

    SBC: KLESIS, LLC            Topic: NCI

    The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 341: Open Scalable Software Infrastructure for Metabolomics Data

    SBC: Kitware, Inc.            Topic: NCI

    Metabolomics research has great potential, and researchers are rapidly producing new techniques for analyzing the large quantities of measurement data in order to utilize metabolomic data more effectively, including promising techniques for data integration across multiple modalities of data from mass spectrometry (MS) and nuclear magnetic resonance (NMR). However, this confluence of data growth a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 374: Targeted and Sustained Release Microparticles for Colon Cancer Chemoprevention

    SBC: Zymeron Corporation            Topic: NCI

    Colorectal Cancer (CRC) is the third most common cancer both in men and women, as well as the second leading cause of cancer deaths with an estimated 135,430 new cases diagnosed and 50,260 deaths for 2017 in the United States. Given the limitations of screening tests and poor prognosis associated with advanced stage colorectal cancer, it would be of great interest in exploring chemoprevention stra ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. The objective of this contract is to develop an HIV latent reservoir assay using a microwell array consumable.

    SBC: Cell Microsystems, Inc.            Topic: NIAID

    A critical remaining challenge toward a true cure for HIV is understanding how latently infected cells evade the immune system and persist as lifelong viral reservoirsOne eradication strategythe so calledshock and killapproachrelies on cell activating compounds to reverse latent infectionand subsequent antiretroviral therapy to eradicate newly activated cellsHoweverthese compounds activate only a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. The purpose of this contract is to develop imprinted polymer resins for the purification of HIV envelope vaccine candidates

    SBC: Zymeron Corporation            Topic: NIAID

    There currently lack diagnostic tools with necessary sensitivity for use in the elimination and post elimination efforts for malaria and other Neglected Tropical DiseasesNTDsMicroscopy and rapid diagnostic testsRDTshave been largely adequate for malaria control and case management but lack the sensitivity to detect low density infectionsAsymptomatic individuals with chronic infection remain reserv ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Thermally Efficient Emitter Technology for Advanced Scene/Simulation Capability in Hardware in the Loop Testing

    SBC: ROBERT A. RICHWINE, LLC            Topic: MDA15014

    We introduce a concept and a design for a high-speed, high-temperature infrared scene projector for midwave (MWIR) and longwave infrared (LWIR) application. Results from study of carbon nanotube (CNT) material characteristics, along with field emission and electro-thermal modeling show that higheffective MWIR temperatures can be sustained and projected by a CNT pixel with little or no spillover to ...

    SBIR Phase II 2018 Department of DefenseMissile Defense Agency
  9. New and Innovative Overhead Persistent InfraRed (OPIR) Sensor Tasking Capabilities

    SBC: BLACK RIVER SYSTEMS COMPANY INC            Topic: MDA13007

    Our objective is to develop and demonstrate an integrated capability to perform dynamic retasking of enterprise wide management of OPIR, radar, and other operationally relevant sensors. The goals of this effort are to refine our existing OPIR tasking approach and to develop and Enterprise SRM approach that will allow the C2BMC to achieve the earliest possible launch detection and maintain the high ...

    SBIR Phase II 2018 Department of DefenseMissile Defense Agency
  10. Configurable Link Test Set (CoLTS) Jamming Capability

    SBC: WELKIN SCIENCES, LLC            Topic: MDA10003

    Under this Phase II SBIR effort Welkin Sciences will design and implement a Jammer Emulator hosted on the MDA sponsored CoLTS-LC hardware platform, originally built for nuclear-effects channel simulation.The Jammer Emulator will support emulation of a wide range of jamming methods, including frequency-following, which is not readily implemented using standard commercial test equipment.A remote int ...

    SBIR Phase II 2018 Department of DefenseMissile Defense Agency

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