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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Aerospace Vehicle Signature Modeling Technologies

    SBC: GoHypersonic Inc.            Topic: MDA15T003

    During hypersonic reentry, the flow around reentry vehicles is dominated by its high enthalpy and high temperature effects, which must be properly modeled in order to generate flowfields from which trustworthy vehicle signatures can be extracted. Ionization, plasmas, non-equilibrium chemistry and modeling of vibration energy, surface chemistry including ablation and associated surface recession, a ...

    SBIR Phase II 2019 Department of DefenseMissile Defense Agency
  2. Improved Techniques for Optimistic Modeling

    SBC: Edaptive Computing, Inc.            Topic: MDA11031

    Running a simulation on a parallel or distributed computing platform can decrease the execution time and improve real-time responsiveness. Optimistic Parallel Discrete Event Simulation (OPDES) model performance improvements derive from partitioning portions of the overall model to distributed computational nodes and executing them concurrently. Executing concurrently yet independently may cause so ...

    SBIR Phase II 2019 Department of DefenseMissile Defense Agency
  3. Rapid, High-Quality C/C Composites

    SBC: Cornerstone Research Group, Incorporated            Topic: SB171013

    Cornerstone Research Group (CRG) is reducing the variability and lead-time associated with production of carbon-carbon composites using MG Resins, a unique, high char yield material system as a replacement to typical phenolic and pitch precursors. In Phase I, CRG proved feasibility through characterization of C/C composites made with MG Resin, in which no densification steps were conducted. Very h ...

    SBIR Phase II 2019 Department of DefenseMissile Defense Agency
  4. High Performance MEMS Inertial Measurement Unit for Missile Systems

    SBC: Spectral Energies, LLC            Topic: MDA17015

    The proposed project aims to improve the SWaP-C of tactical-grade IMUs for use in the navigation system of guided weapons. Spectral Energies and its partners will achieve this goal by using advanced machine learning algorithms to reduce error in commercial-off-the-shelf (COTS) MEMS IMUs.1. Immediate benefits to MDA: The proposed product would provide an IMU to the DOD with comparable precision and ...

    SBIR Phase II 2019 Department of DefenseMissile Defense Agency
  5. Innovative Methodologies for Manufacturing of Lethality Test Articles

    SBC: MRL MATERIALS RESOURCES LLC            Topic: MDA17T001

    Metallic additive manufacturing (AM) is an attractive technology for the production of lethality test articles due to the potential for significantly reduced lead time and manufacturing cost. However, in order to be effective in providing accurate lethality data, the properties of the AM material have to match closely the properties of conventionally manufactured alloys found in real threat target ...

    STTR Phase II 2019 Department of DefenseMissile Defense Agency
  6. TOPIC 356: FLOUROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

    SBC: Lucerna Inc.            Topic: NCI

    Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Topic 374: Topical Delivery of Nanoformulated Bioactive Chemopreventive Agent in Skin Cancer

    SBC: VASCULAR VISION PHARMACEUTICAL CO            Topic: NCI

    We plan to evaluate the chemopreventive management of solar ultraviolet (UV) mediated DNA damage by two different Nanoformulation of epigallicatechin-3-gallate (EGCG). The formulations to be assessed under this study include: a) chitosan based formulation of EGCG (nano-EGCG), and b) EGCG containing chitosan based solid lipid nanoparticles (E-Ch-SLNPs). EGCG is well-tested and popular polyphenol in ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Topic 377: Enabling Clinical Decision Support for Guideline Based Cancer Symptom Management

    SBC: KLESIS, LLC            Topic: NCI

    The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Topic 341: Open Scalable Software Infrastructure for Metabolomics Data

    SBC: Kitware, Inc.            Topic: NCI

    Metabolomics research has great potential, and researchers are rapidly producing new techniques for analyzing the large quantities of measurement data in order to utilize metabolomic data more effectively, including promising techniques for data integration across multiple modalities of data from mass spectrometry (MS) and nuclear magnetic resonance (NMR). However, this confluence of data growth a ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Topic 374: Targeted and Sustained Release Microparticles for Colon Cancer Chemoprevention

    SBC: Zymeron Corporation            Topic: NCI

    Colorectal Cancer (CRC) is the third most common cancer both in men and women, as well as the second leading cause of cancer deaths with an estimated 135,430 new cases diagnosed and 50,260 deaths for 2017 in the United States. Given the limitations of screening tests and poor prognosis associated with advanced stage colorectal cancer, it would be of great interest in exploring chemoprevention stra ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health

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