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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Uncertainty Reduction in High Speed Flight Vehicle Modeling- P4464

    SBC: Materials Sciences LLC            Topic: MDA18T006

    Uncertainty Reduction in High Speed Flight Vehicle Modeling | Approved for Public Release18-MDA-9707 (3 Jul 18)

    STTR Phase I 2019 Department of DefenseMissile Defense Agency
  2. SBIR PHASE I- WEARABLE BIOSENSOR THAT QUANTIFIES BLOOD ALCOHOL CONCENTRATION IN REAL TIME

    SBC: SUGPIAT DEFENSE, LLC            Topic: NIAAA

    Testing Bio Sole biosensor as a wearable technology to quantify BAC in real time

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Rapid Point-of-Care Tests to Simultaneously Quantify Anti-TB Drugs in Blood

    SBC: Zymeron Corporation            Topic: NIAID

    TuberculosisTBis currently the leading infectious cause of death worldwideTB treatment includes multiple different combinations of antibioticsdosesand long time periodsThe current standard includes an intensive phase ofmonthsfollowed by a continuation phase of eitherormonthsHowevertreatment outcome can be poor due to drug drug interactionsimpaired medication adherencedrug absorption and metabolism ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Preclinical Development of Semisynthetic Saponin Immunological Adjuvant Titerquil-1055 in the Context of an Influenza Vaccine

    SBC: ADJUVANCE TECHNOLOGIES, INC.            Topic: NIAID

    Increasingly defined vaccines against infectious diseases are better tolerated but less immunogenicrequiring use of an immunological adjuvant for best effectAdjuvance s semi synthetic saponin adjuvant TiterQuilTQLhas shown remarkable efficacy with a variety of antigens with no detectable reactogenicityWhen combined withof the leading vaccines against influenzaFluzoneFluarix and Flublokstriking aug ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. In Vivo Targeted Degradation of HIV Gag Polyprotein by Gag-PROTAC Reagents

    SBC: Zymeron Corporation            Topic: NIAID

    HIV disease continues to be a serious health issue for the whole worldCurrentlyantiretroviral therapyARTis a widely accepted treatment to HIV infected patientswhich reduces morbidity and mortality and the potential for HIV transmission by suppressing viral replicationHowevertreatment outcomes of ART are limited due to the high adherence requirement and occurrence of drug resistanceProteolysis targ ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Antibody Fragments to Improve HIV gp120 Protein Production

    SBC: Abzyme Therapeutics, LLC            Topic: NIAID

    Camelid single domain antibody fragmentsVHHpossess a number of distinctive features including a small sizean elevated stabilityand an ability to recognize epitopes non accessible for conventional antibodiesBesides common research and immunotherapy applicationscamelid VHHs are also used as co crystallization chaperonesprotein aggregation controllers and enzyme activity tunersIn this proposalwe wish ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A Liposomal Platform for Spontageous, Particleized Presentation of HIV Trimer Immunogens

    SBC: POP Biotechnologies Inc.            Topic: NIAID

    Over one million Americans andmillion people worldwide are infected with HIVmaking it one of the most pressing public health concerns of our timeUnfortunatelythere are no vaccines available and treatment requires lifelong anti retroviral therapiesThis proposal combines two technologies for the development of a vaccine against HIVEnva novel adjuvantspontaneous nanoliposome antigen particleizationSN ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Rapid Point-of-Care Diagnostics to Detect Serologic Status of Individuals for Select Viral Infections

    SBC: Zymeron Corporation            Topic: NIAID

    CytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. TOPIC 372: DEVELOPMENT AND VALIDATION OF CANINE SCFVS FOR PRE-CLINICAL DEVELOPMENT OF TARGETED THERAPEUTICS

    SBC: Vetigenics LLC            Topic: NCI

    The goal of this SBIR is to provide proof of concept of Vetigenicscanine derived scFv phage display platform for rapidcost effective production of highly versatilecanine derived scFvsscFvs against CDCDand CTLAthree high valueimmunological molecules being targeted by antibody based strategies in human cancer immunotherapywill be isolatedSelected scFvs will be sequenced and binding affinities determ ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. TOPIC 386: PROOF OF CONCEPT FOR A TOPICAL MEK INHIBITOR AS A CHEMOPREVENTIVE AGENT FOR SQUAMOUS CELL CARCINOMA IN HIGH RISK ORGAN TRANSPLANT PATIENTS

    SBC: NFlection Therapeutics, Inc.            Topic: NCI

    Solid organ transplantation can be life savingHoweverimmunosuppression necessary to prevent rejection increases the incidence of cutaneous squamous cell carcinomacSCCfoldCurrent treatments for solid organ transplant recipientsSOTRsare largely surgicalwhich can be disfiguring and impact quality of lifeThere is a huge need for a safe and effective chemoprevention agent for cSCC in SOTRsThe RAF MEK E ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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