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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Computer-based Prescription Opioid Abuse Prevention for Adolescents

    SBC: HEALTHSIM, INC.            Topic: R42

    DESCRIPTION provided by applicant Recreational use of prescription opioids among adolescents is a significant and growing public health concern and has been referred to as an emerging epidemic in the U S Although a number of science based interactive drug abuse prevention programs exist focused on preventing use of non prescription drugs among youth to our knowledge no science based inter ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Fluorescence Image-Guided Near Infrared (NIR) Photodynamic Therapy (PDT) Agent

    SBC: PHOTOLITEC LLC            Topic: 102

    DESCRIPTION provided by applicant Photolitecandapos s patented technology is focused on developing improved agents for tumor imaging image guided surgery and or photodynamic therapy PDT The proposed STTR proposal includes fluorescence image guided PDT a andquot See and Treatandquot approach The fluorescence imaging compound with long wavelength absorption near nm should be extremel ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. A Quantitative Optical Sensor to Monitor Tumor Vascular Physiology

    SBC: Zenalux Biomedical, Inc.            Topic: 102

    DESCRIPTION provided by applicant In there were new cases of head and neck cancers HNC in the United States Early detection of new and locally recurrent cancers is clinically important to reduce not only cancer related mortality but also treatment associated morbidity as it impacts multiple organ functions including respiration olfaction hearing eating swallowing and speak ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Development and in vitro validation of therapy for mucopolysaccharidosis III

    SBC: Phoenix Nest Inc.            Topic: 105

    DESCRIPTION provided by applicant Sanfilippo disease mucopolysaccharidosis type III MPS III is a devastating neurodegenerative lysosomal storage disorder of childhood for which there is no cure or effective treatment available The fundamental cause of MPS III is an inherited mutation in one of the enzymes required to catabolize heparan sulfate HS a glycosaminoglycan which plays importa ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Anti-biofilm agents for the treatment of pulmonary infection in cystic fibrosis p

    SBC: AGILE SCIENCES, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The leading cause of mortality in patients with cystic fibrosis CF is pulmonary failure from lung infections and the predominant organism isolated from these infections is the bacterium Pseudomonas aeruginosa Lung infections of CF patients persist over the lifetime of the patients and are impossible to eradicate due to the ability of bacteria to form biofi ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Dityrosine Locked Prefusion F Protein: A Path To A Protective RSV Vaccine

    SBC: AVATAR MEDICAL, LLC            Topic: NIAID

    DESCRIPTION provided by applicant The pre fusion conformation of the RSV F protein preF is the primary determinant of neutralization in immunized sera However this conformation is unstable and rapidly transitions to the postfusion conformation A disulfide stabilized prefusion variant with cavity filling mutations DS Cav has been shown to yield high neutralizing titers in animals howeve ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Ultra-low dose Influenza vaccines

    SBC: Codagenix Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Current seasonal Influenza vaccines are proving to be ineffective especially in at risk populations For example this yearandapos s inactivated flu vaccine had only a efficacy rate against H N infections in the elderly and the current live attenuated Influenza vaccine LAIV is aged restricted for those above years of age Therefore there is glaring un ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. A Novel Recombinant Protein for Mitigating Total Body Radiation Injury

    SBC: THERASOURCE, LLC            Topic: NIAID

    DESCRIPTION provided by applicant This SBIR Phase I proposal is intended to demonstrate the feasibility of developing a novel and effective therapeutic agent for acute radiation injury The threat of nuclear terrorism remains high and there is a possibility of a nuclear power plant leak both of which can cause acute radiation injury at a large scale Currently there are no therapeutic agents ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Enhancing engraftment of cord blood for treatment of neoplastic disorders

    SBC: Marrowsource Therapeutics International LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Hematopoietic stem cell transplantation is a form of stem cell therapy used to treat cancers such as lymphoma and leukemia and other blood related diseases However there currently are several drawbacks in the use of bone marrow hematopoietic cell transplantation Most importantly the donor pool is limited by the need for at least partial HLA matching and t ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. TITER ON CHIP ALTERNATIVE TO SRID FOR INFLUENZA VACCINE POTENCY DETERMINATION

    SBC: INDEVR, INC.            Topic: NIAID

    DESCRIPTION provided by applicant It is widely acknowledged that for split vaccines potency determination is often a rate limiting step The FDA approved andquot gold standardandquot potency assay for influenza hemagglutinin HA protein based vaccines is single radial immunodiffusion SRID SRID is a time and labor intensive assay often requiring days to complete and a minimum of hou ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health

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