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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. PLATFORM FOR NEUROCOGNITIVE EVALUATION AND MONITORING

    SBC: ENFORMIA INC.            Topic: NCI

    Current standardized neuropsychological tests are based on decades old paper and pencil methods They lack reliability sensitivity specificity repeatability and require trained neuropsychologists to administer them Their administration in clinical and research settings result in high cost complexity and inconsistent results There is a need and a commercial opportunity for an extensible co ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. An RNA targeted platform for anti flavivirus drug discovery

    SBC: Ribometrix LLC            Topic: NIAID

    SUMMARY Emerging and re emerging mosquito borne flaviviruses cause widespread mortality morbidity and economic burden Options for prevention and treatment of mosquito borne flaviviruses are limited Flavivirus vaccines face unique development challenges no antiviral therapies are available and the mosquito vectors have proven difficult to eradicate Despite vaccines against Yellow Fever and J ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Supporting Healthy Aging with a Phytochemical Combination that Acts at Multiple Control Points in the Nrf Activation Pathway

    SBC: Pathways Bioscience, LLC            Topic: NIA

    The average lifespan and the number of older individuals is increasing in the US but because age is a primary risk factor for most chronic disease there is an accompanying increase in the burden of chronic disease in the US Diet and lifestyle choices including dietary supplementation may be useful approaches to slowing the aging process and increasing healthspan and also may be the best stra ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Enhancing cytarabine efficacy in leukemia through CDK inhibition

    SBC: SENEX BIOTECHNOLOGY, INC.            Topic: 102

    Acute myeloid leukemia AML is the most common acute leukemia in adults with new cases annually in the US A deoxycytidine nucleoside analog Cytarabine AraC is the principal chemotherapeutic agent used in AML AraC containing chemotherapeutic regimens induce complete remission in of newly diagnosed AML patients but a substantial minority of leukemias is intrinsically resistant t ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. "Modulation of Immune Checkpoints by Self Deliverable RNAi for Adoptive Cell Transfer"

    SBC: ADVANCED RNA TECHNOLOGIES LLC            Topic: 102

    Two of the most promising approaches to cancer immunotherapy are immune checkpoint blockade by monoclonal antibodies and the adoptive transfer of immune cells The recent successes in treating melanoma with anti PD and anti CTLA antibodies as well as the extremely successful application of T cells engineered to express the CAR receptor targeting CD to treat B cell lymphomas initiated a waterfal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Peptide based tool for the rapid isolation of quiescent monocytes from peripheral blood

    SBC: AFFINERGY, LLC            Topic: 102

    SUMMARY ABSTRACT Dendritic cell DC therapy represents a new and promising immunotherapeutic approach for treatment of advanced stage cancers with DC vaccines already approved for use in advanced prostate cancer and more than DC based vaccines in the clinical development pipeline for other cancers In particular the US market for cancer vaccines including DC based vaccines is set to expan ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. High sensitive and specific Point of use lateral flow strip for on site test of cannabis intoxication

    SBC: Vitan-Biotech LLC            Topic: NIDA

    Project Summary Marijuana e g cannabis is the most frequently detected drug of abuse Cannabis abuse has a substantial impact on public safety as driving under the influence of cannabis will impair driving skill and the marijuana use in the workplace will increase the risk of adverse events and the loss of productivity With the recent wave of legalization of marijuana use in numerous states ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Novel injectable resiquimod formulation for treatment of metastatic cancers

    SBC: Curebiotech, Inc.            Topic: NCI

    PROJECT SUMMARY Malignant melanoma is one of the most aggressive types of skin cancer causing a large majority of skin cancer related deaths worldwide Recently there have been staggering breakthroughs with the advent of drugs that act on checkpoint inhibitors These are paradigm shifting immunotherapeutic agents not only for melanoma but for cancers in general because they harness the bodyan ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. CRISPR Cas Systems Delivered by Targeted Nanoparticles to Eradicate Herpesvirus Pathogens

    SBC: Theragnostic Technologies Inc.            Topic: NIAID

    Abstract Herpesviruses are chronic pathogens that infect for life there is no cure years since the discovery of the first tumor virus the herpesvirus Epstein Barr virus EBV there exist no specific antivirals for EBV during its latency phase and there are no vaccines The same holds true for most of the other eight human herpesviruses This proposal aims to develop novel tools to eradicat ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. A Nitric Oxide Polymer Platform for the Prevention and Treatment of Infected Wounds

    SBC: IFYBER, LLC            Topic: NIAID

    This proposed SBIR research effort will lay the foundation for commercializing a new class of biomaterial for the prevention and treatment of infected skin wounds thereby enhancing patient health through improved patient outcome and reduced patient morbidity Specifically we will focus on evaluating and developing a biomaterial comprised of a nitric oxide NO releasing based on a commonly used ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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