Award Data

Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

ColdQuanta is developing a highly-integrated, compact physics package that will reduce the size, weight, and power (SWaP) of the next-generation of space-based optical clocks. The key element of this system is the development of an ultrahigh vacuum (UHV) manifold for laser cooling strontium. The extremely narrow linewidth of strontiums optical intercombination transition is ideal for constructing ...

Dielectric materials, which store energy electrostatically, are ubiquitous in advanced electronics and electric power systems. Polymer dielectrics have highbreakdown strengths and excellent reliability, are scalable, lightweight and can be shaped into intricate configurations, and are therefore an ideal choice for many power electronics, power conditioning, and pulsed power applications. A variety ...

As organizations grow in size and complexity, it is only natural that inefficiencies exist. One of the challenges faced by organizations is the information needed to identify, characterize, and resolve these inefficiencies is located in different stovepipes and may be biased based on a variety of factors. Both crowdsourcing and human computation research and design thinking practices have develope ...

The next generation of Multifunctional Information Distribution System (MIDS) radio terminals are currently under development and the Navy is in need of improved thermal management to enable the current state of the art signal processing capabilities within the currently deployed fleet environment. Roccor proposed to leverage its FlexCoolTM technology in partnership with ViaSat to design, develop ...

Modeling and simulation play a critical role in the design and evaluation of high power microwave (HPM) devices. However, many of the most recent simulation methods have yet to be adopted by Navy scientists in their design process, in part because these methods need additional improvements and need to be shown to work on problems of interest to the Navy. Improvements to Magneto-hydrodynamics (MHD) ...

This SBIR Phase II proposal for a Common Embedded Vehicle Network Diagnostics Interface Hardware (CEVNDIH) for an IEEE-1394 based AS5643 network implementation is focused on IEEE-1394 PHY, Link and Open Host Controller (OHCI) optimizations, diagnostics and enhancements. The resulting implementation is designed; a) to create improvements to help maintenance personnel isolate subsystem, wiring, or c ...

As a cloud-like architecture is adopted by mission critical System of Systems (SoS), the problem of system management is critically important to solve in order to ensure continuity of operations. System operators and maintainers need a way to manage system resources and restore a system to health when subsystems in the SoS are sharing these resources. A technology to determine and present Courses ...

This STTR Phase I project will undertake the development of iron coordination complexes as alternatives for gadolinium contrast agents which are currently used in clinical MRI diagnostic exams. New MRI contrast agents are needed to serve the segment of the population who cannot tolerate Gd(III) agents. This includes patients with kidney disease and those who have frequent MRI scans and may accumul ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project will be to develop engineered bacteria with the ability to oxidize the copper mineral chalcopyrite and gold. The majority of copper reserves are in chalcopyrite, which currently requires smelting. The US copper mining industry, due to regulatory restrictions, has a limited smelting capacity forcing US ...