Award Data

Abstract for Supplement ApplicationThe ultimate goal for our original project was to complete the proof-of-concept work, and the multitude of pharmacodynamic, pharmacokinetic, toxicokinetic, safety, and toxicology studies required by the FDA to apply for an IND. We are fully satisfied that we have generated a new chemical entity that acts at a novel binding site on the GABA-A receptor and acts in ...

Project SummaryAbstract! An!estimated!!infants!delivered!annually!in!the!United!States!are!born!with!birth!defects!caused!by!the!use!of! medication!during!pregnancy !!Since!the!peak!prevalence!of!some!diseases !such!as!hypertension !autoimmune!disease ! and!depression !occurs!during!the!childbearing!years !it!is!not!surprising!that!medication!use!during!pregnancy!is! common !with!nine!out!of!ten!p ...

The myCare2 solution will be marketed to cancer care organizations and include three separate portals for cancer caregivers, patients and providers. The system will be mobile-enabled and support standards-based EHR integration. Primary myCare2 features include symptom assessment, communication with the care team, care plan dissemination, tailored education content for caregiving and for caregiver ...

Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

Given the benefits of exercise on general health, orally active compounds that can mimic or potentiate the effects of exercise have been of keen interest as therapeutic and dietary ingredients. Our proposed approach for enhancement of USSOCOM Multi-Purpose Canine (MPC) endurance and sensory performance using an exercise mimetic is based on the observation that age-related decline of nicotinamide ...

SeaLandAire Technologies, Inc. (SLA) proposes to meet this Group 2 need with an electric drive concept that will be capable of a 20-30 lbs. modular payload, with comparable range and endurance to current grp 2 ISR UAS, while still maintaining sufficient ISR capabilities. This UAS concept is able to covertly and safely deliver payload to within 1 meter accuracy, then extract a different payload an ...

ColdQuanta is developing a highly-integrated, compact physics package that will reduce the size, weight, and power (SWaP) of the next-generation of space-based optical clocks. The key element of this system is the development of an ultrahigh vacuum (UHV) manifold for laser cooling strontium. The extremely narrow linewidth of strontiums optical intercombination transition is ideal for constructing ...

Dielectric materials, which store energy electrostatically, are ubiquitous in advanced electronics and electric power systems. Polymer dielectrics have highbreakdown strengths and excellent reliability, are scalable, lightweight and can be shaped into intricate configurations, and are therefore an ideal choice for many power electronics, power conditioning, and pulsed power applications. A variety ...

The next generation of Multifunctional Information Distribution System (MIDS) radio terminals are currently under development and the Navy is in need of improved thermal management to enable the current state of the art signal processing capabilities within the currently deployed fleet environment. Roccor proposed to leverage its FlexCoolTM technology in partnership with ViaSat to design, develop ...

Modeling and simulation play a critical role in the design and evaluation of high power microwave (HPM) devices. However, many of the most recent simulation methods have yet to be adopted by Navy scientists in their design process, in part because these methods need additional improvements and need to be shown to work on problems of interest to the Navy. Improvements to Magneto-hydrodynamics (MHD) ...