Award Data

DESCRIPTION (provided by applicant): IV amiodarone is the first line therapy for life threatening ventricular as well as supraventricular arrhythmias. However, the Tween 80 and benzyl alcohol diluents limits the rate of administration severely, due to hypotension and myocardial contractile depression. These adverse toxicities contribute to the high mortality of cardiac arrest patients who have ma ...

In traditional GMAW and modifications, the current melting the wire is the same as the current heating the base metal. To maintain a minimally acceptable productivity, the base metal heat input is typically much greater than the required to control the distortion at an acceptable or desirable level. In the modified GMAW proposed, a bypass torch is added to an existing GMAW system to bypass part of ...

This Small Business Innovation Research (SBIR) Phase I project will develop boron-doped ultrananocrystalline diamond (UNCD) electrodes for electrochemical treatment/destruction of recalcitrant organics in industrial wastewater via direct anodic oxidation. Boron-doped diamond (BDD) film electrodes have generated considerable interest due to their ability to readily mineralize complex waste streams. ...

This Small Business Innovation Research Phase I project will investigate UNCDýý, a nanocrystalline from of smooth, thin diamond, as an anti-thrombotic coating for implantable medical devices. One of the largest problem with implantable circulatory assist devices such as artificial hearts and vascular assist devices (VADs) is the need to treat patients with anticoagulants to avoid blood clots wit ...

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Phase I project will develop ultrananocrystalline diamond (UNCD?) as a high frequency structural layer for piezoelectrically-transduced micromachined RF resonators for MHz-GHz applications in wireless telecommunication systems. Diamond, in theory, is the ideal ...

Research is proposed for the development and implementation of state of the art, reduced order nonlinear aeroelastic models for multidisciplinary/multi-fidelity optimization problems. Highly efficient and accurate aeroelastic simulation tools will be constructed based upon the mathematical formalism of optimal prediction theory and a novel implementation of a filtered harmonic balance solution met ...

The proposed research program will develop a physics-based identification, modeling and risk management infrastructure for aeroelastic transonic flutter and limit-cycle oscillations (LCO). This capability will be built upon high fidelity state-of-the-art theoretical/computational methods as validated and verified by available experimental data bases, and will include (1) rapid flutter boundary det ...

The proposed work aims at developing techniques that will address the current limitations of Cartesian-based Navier-Stokes CFD schemes by exploring three promising methods of implementing improved wall boundary conditions. The three methods are based on: (1) the diamond stencil approach of Delanaye et al., (2) the extrapolation boundary condition work by Marshall and Ruffin, and (3) the Material P ...

This SBIR aims at developing a high-fidelity, yet efficient and easy-to-use, composite rotor blade and wing section design environment to facilitate rapid and confident aeromechanics assessment during conceptual design stages. A well-known technical barrier for composite rotor blade and wing section design is the lack of a user friendly, efficient and high-fidelity design tool to realistically rep ...

DESCRIPTION (provided by applicant): Important advances have been made in the treatment of viral infections over the last two decades, especially with the extensive availability of drugs to treat HIV infection, but there is a need to develop new drugs particularly with the challenges facing HIV vaccine development and the propensity to develop drug resistance. With FDA approval in 2007 of the firs ...