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MAPPING AND SEQUENSING THE DNA IN THE HUMAN GENOME IS OF CRUCIAL IMPORTANCE TO FUTURE MEDICAL ADVANCES AND ECONOMIC COMPETITIVENESS. UTILIZATION OF DNA PROBES LABELED WITH DOZENS OF STABLE ISOTOPES INSTEAD OF A SINGLE RADIOISOTOPE COULD INCREASE THE RATE OF SEQUENCE DETERMINATION 100-FOLD OR MORE COMPARED TO CURRENT METHODS. THIS PROJECT INVOLVES A NEW APPROACH, LASER ATOMIZATION RESONANCE IONIZAT ...

THE NEED TO MAP AND SEQUENCE DNA IN THE HUMAN GENOME IS OF CRUCIAL IMPORTANCE FOR A BETTER UNDERSTANDING OF GENETICS AND DISEASE PROCESSES. CURRENT DNA SEQUENCING PROCEDURES ALMOST UNIVERSALLY REQUIRE GEL ELECTROPHORESIS OF DNA FRAGMENTS, AND SEVERAL LABORATORIES ARE DEVISING PROCEDURES TO AUTOMATE AS MANY STEPS OF THIS PROCESS AS POSSIBLE. SEQUENCING BY HYBRIDIZATION (SBH) PROPOSED BY DRMANAC ET ...

THE USE OF TRACERS TO TAG WELL GAS WHICH IS REINJECTED INTO OIL RESERVOIRS HAS ACHIEVED CONSIDERABLE SUCCESS IN CHARACTERIZING THE STRUCTURE AND GEOMETRY OF THE RESERVOIRS. IDEALLY, THE TRACER SHOULD BE DETECTABLE OVER A WIDE DYNAMIC RANGE, PARTICULARLY IN FIELDS WHERE LARGE VOLUMES OF GAS ARE INJECTED. THE OBJECTIVE OF THE PROPOSED RESEARCH IS TO DEMONSTRATE ORDERS-OF-MAGNITUDE INCREASE IN DYNAMI ...

THIS PROJECT WILL ESTABLISH THE POTENTIAL FOR RAPID RESPONSE, HIGH RESOLUTION DETECTION AND CHARACTERIZATION OF INFRARED (IR) ACTIVE POLLUTANT MOLECULES, SUCH AS S02, N0, AND N02. MINIATURE OPTICAL HEAT PIPES WILL BE CONSTRUCTED AND OPTIMIZED FOR THE GENERATION OF TUNABLE IR LASER LIGHT BY MEANS OF STIMULATED ELECTRON RAMAN SCATTERING (SERS). THE HEAT PIPES WILL USE ALKALI METAL VAPORS AT PRESSURE ...

THIS PROJECT WILL RESULT IN THE DEVELOPMENT OF A NEW TECHNOLOGY FOR MEASURING THE QUANTITY AND LOCATION, WITH SUBMICRON RESOLUTION, OF BORON IN BIOLOGICAL CELLS IN SUPPORT OF THE BORON NEUTRON CAPTURE THERAPY (BNCT) PROGRAM. THIS PROJECT THUS ADDRESSES THE MAJOR UNSOLVED TECHNICAL ISSUE IMPACTING BNCT CLINICAL EFFICACY. BNCT IS APROMISING RADIATION THERAPY IN WHICH NEUTRONS ARE USED TO ACTIVATE BO ...

DEMONSTRATION TESTING OF ADVANCED PROCESS EQUIPMENT IS EXPECTED TO CONFIRM THE FEASIBILITY OF THE INTEGRAL FAST REACTOR (IFR) FUEL CYCLE PROCESS AT THE HOT FUEL EXAMINATION FACILITY - SOUTH (HFEF-S) ON THE ARGONNE-WEST SITE IN IDAHO. TEST RESULTS WILL BE INCORPORATED INTO THE DESIGN OF A COMMERCIAL IFR FUEL CYCLE FACILITY. THIS PROJECT CONTRIBUTES TO DEVELOPMENT OF A CONCEPTUAL DESIGN FOR AN ADVAN ...

SORPTION-TYPE HEAT ACTIVATED HEAT PUMPS USING COMPLEX COMPOUNDS AS THE SORBENT MEDIA ARE A VERY PROMISING DEVELOPMENT. THIS PROJECT ADVANCES AN INNOVATIVE STAGING TECHNIQUE THAT GREATLY INCREASES THE COEFFICIENT OF PERFORMANCE (COP) ACHIEVABLE WITH COMPLEX COMPOUND SORPTION CYCLES. THIS STAGING METHOD IS THE FIRST CONCEPT IN WHICH MORE THAN THREE EFFECTS ARE PRACTICAL. INCREASES IN HARDWARE REQUIR ...

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REMOTE MAINTENANCE OF THE COMPACT IGNITION TOKAMAK (CIT) POSES FORMIDABLE CHALLENGES BECAUSE OF ITS INTERNAL DIMENSIONAL CONSTRAINTS, DIVERSITY OF MAINTENANCE OPERATIONS, AND GEOMETRICALLY INTRICATE ARRANGEMENT OF EXTERNAL SERVICE EQUIPMENT. THESE CHALLENGES MUST BE ADDRESSED TO SUPPORT FUTURE "HOT" OPERATION OF THE PRINCETON PLASMA PHYSICS LABORATORY (PPPL) CIT. PHASE I INTRODUCES A SINGLE SOLUTI ...