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Avian coccidiosis is the major parasitic disease of poultry that can result in the deaths of millions of birds in a short time. Prophylactic medication and live parasite vaccines are employed as therapeutics. The development of parasite strains resistant to drug treatments, and immune-evasive mutations introduced in response to live parasite treatments will soon limit the effectiveness. The USDA A ...

Achievement levels of U.S. K-12 students continue to decline compared with those of students in many foreign countries - especially in math and science. Based on current U.S. standards alone, two-thirds of our 8th grade students lack proficiency in core disciplines related to science, math, and reading. This same data for many of our resource-limited rural school districts is even more troubling. ...

Glyphosate had been used for decades as a pre-emergence herbicide in commercial agriculture. The introduction of herbicide-resistant GMO soybeans and other herbicide-resistant crops made glyphosate the most popular herbicide for grain farmers in the U.S. As the use of glyphosate in post-emergence applications increased, several important weeds, among them Palmer amaranth or pigweed (Amaranthus pal ...

Dioxin and other dioxin-like chemicals are persistent environmental pollutants that threaten human and animal health due to their stability in the environment and their ability to accumulate in the food chain toward eventual human consumption. Incidents of dioxins being found in the food and animal feed chain have led to numerous recalls with consequent impacts on human and animal health as well a ...

DESCRIPTION provided by applicant This Small Business Technology Transfer STTR Phase I project proposes to develop autonomously bioluminescent human stem cells for continuous reagent free and real time bioimaging to address the National Institutes of Healthandapos s request for new techniques for non invasive long term tracking of stem cell survivability engraftment and migration followi ...

DESCRIPTION provided by applicant Latinos Kick Buts Mobile Engagement and Cessation Support for Latino Smokers Latinos are less likely than non Hispanic whites to have access to health to have knowledge of existing smoking cessation resources to receive advice to stop smoking and to participate in smoking cessation programs Mobile technologies can dramatically enhance the reach of effectiv ...

DESCRIPTION provided by applicant The looming threat of nuclear attacks and recent non terrorist related accidents Fukushima nuclear disaster has increased national and global attention to the need for medical countermeasures RxBio has identified a first in class proprietary small molecule Rx which significantly protects the gut and the hematopoietic system from exposure to lethal doses o ...

DESCRIPTION provided by applicant Expanding the throughput of real time toxicological screening of cardiac differentiation by expressing a synthetic luciferase luciferin genetic pathway in iPSCs Project Summary This Small Business Innovation Research SBIR Phase I project proposes to develop autonomously bioluminescent induced pluripotent stem cells iPSCs for continuous reagent free and ...

DESCRIPTION provided by applicant Secretory diarrhea is a leading cause of death worldwide among children under the age of five Its pathology involves cystic fibrosis transmembrane conductance regulator CFTR which provides a primary pathway for Cl secretion Targeting CFTR to prevent reduce losses of electrolytes and water is a therapeutic strategy Lysophosphatidic acid LPA a naturally o ...

DESCRIPTION provided by applicant Development of a high throughput screen to detect the effects of both pre and post biotransformed compounds for enhanced content drug discovery workflows Project Summary This Small Business Innovation Research Phase I project proposes to engineer a panel of autonomously bioluminescent human cell lines for the simultaneous high throughput detection of both p ...