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Ocular traumas resultingfrom explosive or incendiary devices arecommon battlefield injuries. Current therapeutics do not address the biological and molecular processes in corneal wound healing, and therapeuticfailureis associated with corneal ulcers,scarring, and vision loss. Ocular therapeutics that haveregenerative healing properties and restorecorneal biomechanical integrity and can bereadily a ...

Vitrification, cryopreserved storage in a “glassy” rather than crystalline phase, is an important enabling approach for tissue banking and regenerative medicine, offering the ability to store and transport cells, tissues and organs for a variety of biomedical uses without the risks of damaging ice formation. Unfortunately, practical application of vitrification has been limited to reproductive ...

We will evaluate a novel warming method, developed by our collaborator John Bischof, that promises solution of one of the remaining barriers for banking of large organs and vascularized composite tissues. The method involves radiofrequency and magnetic nanoparticles to obtain rapid uniform electromagnetic rewarming of biological materials instead of warming from the outer boundary using convection ...

The long term goal of the proposed research is to develop improved methods for cryopreservation of complex tissues at extreme low temperature. An innovative approach is taken in the proposed line of research, where synthetic ice modulators (SIMs) are combined with established cryoprotective agent (CPA) cocktails to create more favorable conditions for cryopreservation in a process known as vitrifi ...