Award Data

This Small Business Technology Transfer Phase II effort aims to develop a fully integrated, modular human surrogate, a software suite, and wireless data transmission.  The main goals of the Phase II project will be to increase the biofidelity, modularity, and manufacturability of the low-cost, sensor-integrated surrogate developed in Phase I.  In Phase II, the prototype that was developed in Pha ...

This Small Business Technology Transfer Phase I effort aims at the feasibility of developing a low-cost, modular human surrogate including a sensory system and organ models with integrated pressure sensors.  The proposed system will be utilized for evaluating personal protective equipment (PPE).  Current human surrogates are either costly or do not provide adequate pressure measurements. The pr ...

The goal of the proposed Small Business Technology Transfer (STTR) Sequential Phase II project is to further develop a wearable, three-dimensional (3-D) underwater explosion (UNDEX) blast exposure monitoring system.  To date, there are no wearable blast sensors available to correlate UNDEX blast exposure data to diver injuries.  The uniqueness of the proposed 3-D OmniBlast Water (OBW) sensor is ...

Ocular traumas resultingfrom explosive or incendiary devices arecommon battlefield injuries. Current therapeutics do not address the biological and molecular processes in corneal wound healing, and therapeuticfailureis associated with corneal ulcers,scarring, and vision loss. Ocular therapeutics that haveregenerative healing properties and restorecorneal biomechanical integrity and can bereadily a ...

Advanced Materials and Devices, Inc. (AMAD), in a 12-month TRL Booster Pilot effort, will move the development and manufacturing of a wearable, wireless, in-air and underwater sensor from TRL 5-6 to a TRL of 6-7. At the end of the TRL Booster Pilot effort, the wearable sensor will be ready for qualification testing and manufacturing via Phase III funding. At the end of the current Phase II effort ...

This Small Business Technology Transfer (STTR) Phase I effort will demonstrate the feasibility of using piezoelectric fibers to detect shock waves from underwater explosions (UNDEX) and sensing physiological measures such as heart and respiratory rates on warfighters. Piezoelectric fibers will be characterized for their ability so sense different amplitudes and frequencies of shock and vibration. ...

Vitrification, cryopreserved storage in a “glassy” rather than crystalline phase, is an important enabling approach for tissue banking and regenerative medicine, offering the ability to store and transport cells, tissues and organs for a variety of biomedical uses without the risks of damaging ice formation. Unfortunately, practical application of vitrification has been limited to reproductive ...

We will evaluate a novel warming method, developed by our collaborator John Bischof, that promises solution of one of the remaining barriers for banking of large organs and vascularized composite tissues. The method involves radiofrequency and magnetic nanoparticles to obtain rapid uniform electromagnetic rewarming of biological materials instead of warming from the outer boundary using convection ...

Lyme disease is a vector-borne illness caused by infection with B. burgdorferi. Hard ticks (Ixodes spp.) acquire the spirochete from a natural reservoir of small mammals; transmission to humans occurs via the bite of an infected tick. By any measure, Lyme disease is one of the most serious emerging infectious diseases that threaten public health in the United States. New estimates from the CDC ind ...

The long term goal of the proposed research is to develop improved methods for cryopreservation of complex tissues at extreme low temperature. An innovative approach is taken in the proposed line of research, where synthetic ice modulators (SIMs) are combined with established cryoprotective agent (CPA) cocktails to create more favorable conditions for cryopreservation in a process known as vitrifi ...