Award Data

Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are an abundant component of the epitranscriptome. Putative functions of circRNAs, include miRNA sequestration, RNA-binding protein scaffolding, mRNA trapping, and protein translation regulation. Deregulation in one or more of these roles has been linked to several types of cancer, including pancreatic cancer, basal cell carcinoma, ...

Aging military infrastructure is constantly in the need of replacement and upgrades. Competent and qualified domestic producers of these mission vital items are becoming increasingly scarce leading to fewer sources and less competition in the marketplace. To ensure that warfighters are properly equipped to perform their missions it is critical to have a reliable and sustainable supplier base wit ...

ORBIS proposes to Address SBIR DLA171-002 by developing efficient and effective processes to reverse engineer RPPOB Candidate Items. ORBIS has a wealth of experience in supporting DoD systems and components and is well suited to addressing the backlog of unsupported equipment .

To facilitate amphibious assault operations, the Marines need to quickly move amphibious combat vehicles (ACVs) between ships and the shore. However, due to an increased level of sophistication in the anti-ship weapons available to potential adversaries, Navy ships must remain far from shore during assault operations (i.e., many tens of miles). This creates a need for assault vehicles that can ach ...

The Multifunctional Information Distribution System (MIDS) Joint Tactical Radio (JTRS) is a four-channel, software-programmable radio having up to eight Shop Replaceable Units (SRUs) that determine the functionality of the unit. The SRUs consist of electronics cards mounted in a sealed structure and secured in the chassis using standard wedge locks. Currently, the available heat rejection from the ...

This STTR Phase I project will undertake the development of iron coordination complexes as alternatives for gadolinium contrast agents which are currently used in clinical MRI diagnostic exams. New MRI contrast agents are needed to serve the segment of the population who cannot tolerate Gd(III) agents. This includes patients with kidney disease and those who have frequent MRI scans and may accumul ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will serve two complementary unmet market needs by: (1) accelerating the evaporation rate of brine ponds and enhancing salt production efficiency by 2-3 times; (2) condensing the moisture evaporated from contaminated/salty water so that one can obtain clean drinking water with n consumption of ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to significantly reduce primary care physician shortages and improve quality of care for low income patients in the United States by developing a tool that analyzes clinical care team performance data at federally qualified health centers (FQHCs) to automatically deploy individually tailore ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project is to produce polymer composites that enable commercialization of alkaline electrochemical devices, such fuel cells and electrolyzers. The use of fuel cell technologies will help preserve the environment, mitigate climate change, decreasing our carbon footprint and securing renewable energy supply. El ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project, if successful, will be the implementation of an effective point-of-care (POC) test that will not only impact the lives of patients, but can reduce the costs to hospitals, health insurances companies, and government agencies. According to the National Institutes of Health, cancer cost the U.S. ...