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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biodegradable Lubricants from Renewable Feedstocks

    SBC: Tetramer Technologies,L.L.C.            Topic: 88

    Current agriculture and off-road equipment requires the use of lubricants to ensure efficient operation of integral hydraulic and gear driven systems. The lubricants, either oils or greases, aid in reducing friction, dissipating heat, prevent oxidation, and seal of water and debris from vital areas of the equipment. During operation, equipment may have slight leaks or suffer catastrophic failures ...

    SBIR Phase I 2018 Department of Agriculture
  2. Proximity-Based Fire Alert Notifications for Hearing Impaired

    SBC: KnewTek            Topic: na

    This project develops smoke detector hardware and an associated smartphone application which, upon detection of an environmental threat (e.g., a fire), automatically pushes alert notifications directly to individuals who are Deaf or hard of hearing via a cellular telephone or smart device application. The alert notifications are transmitted to telephones or smart devices within proximity of the sm ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Nucleobase aminosugars with reduced ototoxicity

    SBC: NUBAD, LLC            Topic: Y

    PROJECT SUMMARYAminoglycosides are one of the cheapest and well known antibiotics in clinical use for overyearsbut one of the major limitations in their use is their ototoxicityWe are developing fast and low cost methods to develop aminoglycosides with antiribosomal activities and reduced toxicityIn this projectwe will identify novel aminoglycoside antibacterialsthat show reduced ototoxicityComple ...

    STTR Phase I 2018 Department of Health and Human Services
  4. Proteasome inhibitor re-sensitizing molecules for treatment of refractory multiple myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: 102

    Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

    STTR Phase II 2018 Department of Health and Human Services
  5. A Double Balloon Catheter for the Treatment of Intussusception in Children

    SBC: Sealcath, LLC            Topic: NICHD

    PROJECT SUMMARY ABSTRACT During Phase ISealCathLLC will test the feasibility of its innovative Double Balloon CatheterDBCwhich the United States Utility Patent application was approved on Augustand is in the process of issuing a patentLicensed from the Medical University of South Carolinathis DBC will be commercialized in Phase III as the trademarked nameCephus Catheterwith targeted end users bein ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. ClearScope

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    Combined in vivo and ex vivo three dimensionalDwhole brain imaging of non transgenic and transgenic animal models holds the promise of novel insights into neural network connectivity patternsWith regard to ex vivo light microscopic imaging ofD whole brain datasetsthe best approach is brain clearing followed by whole brain light sheet microscopyLSMbecause of its unique combination of speedD resolvi ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. CranialProgrammer: Image-Guided Directional Deep Brain Stimulation Programming Using Local-Field Potentials

    SBC: Nexeon Medsystems Puerto Rico Operating Company Inc            Topic: 105

    ABSTRACT The goal of this Uproposal is to develop and test CranialProgrammeran image guided programming tool forDD mapping of disease related neural signals over patient and device data for more efficient and effective programming of directional deep brain stimulationDBSsystemsDBS is an established treatment for advancedrefractory movement disorders used in overpatientsHowevermany patients receive ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. A Reliable Switched Angle Spinning (SAS) Probe with Gradients (PFG) for Proteins in Solid-State NMR

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    A Reliable Switched Angle SpinningSASProbe with GradientsPFGfor Proteins in Solid State NMR AbstractSolid state NMRssNMRbiotechnology is emerging as an alternative method of choice for highresolution structure determination for integral membrane proteinsIMPsssNMR provides a unique platform to investigate protein dynamicsand functional studies of wide range of biomolecules in their supramolecular a ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Development of an Enhanced, Simplified Blood Coagulation Test to Monitor Patients on Direct Oral Anti-Coagulants

    SBC: Haematologic Technologies, Inc.            Topic: NHLBI

    Project SummaryOver the lastyearsDirect Oral AnticoagulantsDOACshave become increasingly prevalent for treating patients with cardiovascular disorders because of their pharmacokinetic stability and lack of interaction with certain foodsYetthere is increasing evidence of improper dosing in a small proportion of treated patientsand growing recognition of the need to develop simpleinexpensive tests t ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Novel therapeutic approach in treatment of glioblastoma using sustained delivery of Connxin43 carboxy-terminal peptide encapsulated in biodegradable nanoparticles in combination with temozolomide

    SBC: FirstString Research, Inc            Topic: 102

    PROJECT SUMMARY GlioblastomaGBMis an incurable cancer even with aggressive therapies such as surgical resection followed by radiotherapy and chemotherapy using temozolomideTMZEfforts to improve surgical resection or the efficacy of irradiation are limited by the potential damage these interventions cause to the brainIn contrastsensitizing GBM to TMZ is an appealing strategy because TMZ has excelle ...

    SBIR Phase II 2018 Department of Health and Human Services

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