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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Natural Immune Boosting Compounds as Alternatives to Antibiotics

    SBC: ALTBIOTICS, LLC            Topic: 83

    Routine use of antibiotics at subtherapeutic levels in the livestock industry has been criticized for triggering antimicrobial resistance. FDA has recommended the withdrawal of medically important antibiotics for production practices in the U.S. as of January 2017. Although various alternatives to antibiotics are currently on the market, none is able to match the efficacy of antibiotics. We recent ...

    SBIR Phase I 2018 Department of Agriculture
  2. Biodegradable Lubricants from Renewable Feedstocks

    SBC: Tetramer Technologies,L.L.C.            Topic: 88

    Current agriculture and off-road equipment requires the use of lubricants to ensure efficient operation of integral hydraulic and gear driven systems. The lubricants, either oils or greases, aid in reducing friction, dissipating heat, prevent oxidation, and seal of water and debris from vital areas of the equipment. During operation, equipment may have slight leaks or suffer catastrophic failures ...

    SBIR Phase I 2018 Department of Agriculture
  3. Adding Value and Sustainability to the Food Industry: Mealworm Protein Ingredient as Extract and Powder

    SBC: ALL THINGS BUGS LLC            Topic: 85

    Adding Value and Sustainability to the Food Industry: Mealworm Protein Ingredient as Extract and PowderThe goal of this SBIR effort is to contribute value and ingredient diversity to the food industry. The insect based food market is currently valued at $105M and is growing to $1.53 billion by 2021. To date only whole insect powders, not fractionated or extracted protein products made from insects ...

    SBIR Phase II 2018 Department of Agriculture
  4. Proximity-Based Fire Alert Notifications for Hearing Impaired

    SBC: KnewTek            Topic: na

    This project develops smoke detector hardware and an associated smartphone application which, upon detection of an environmental threat (e.g., a fire), automatically pushes alert notifications directly to individuals who are Deaf or hard of hearing via a cellular telephone or smart device application. The alert notifications are transmitted to telephones or smart devices within proximity of the sm ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Nucleobase aminosugars with reduced ototoxicity

    SBC: NUBAD, LLC            Topic: Y

    PROJECT SUMMARYAminoglycosides are one of the cheapest and well known antibiotics in clinical use for overyearsbut one of the major limitations in their use is their ototoxicityWe are developing fast and low cost methods to develop aminoglycosides with antiribosomal activities and reduced toxicityIn this projectwe will identify novel aminoglycoside antibacterialsthat show reduced ototoxicityComple ...

    STTR Phase I 2018 Department of Health and Human Services
  6. Proteasome inhibitor re-sensitizing molecules for treatment of refractory multiple myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: 102

    Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

    STTR Phase II 2018 Department of Health and Human Services
  7. Development of a DCLK1 siRNA Nanoparticle as Targeted Therapy to Treat Pancreatic Cancer

    SBC: COARE Holdings, Inc            Topic: NCI

    AbstractPancreatic ductal adenocarcinomaPDACis one of the most devastating human cancersIt is the fourth leading cause of cancer related deaths in the U Sannuallywith a andltyear survival rateDespite FDA approved therapeutic regimens and marked improvements in medical and surgical careno significant impact on PDAC patient survival has been achievedInsomeAmericans are expected to be diagnosedandare ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. A Double Balloon Catheter for the Treatment of Intussusception in Children

    SBC: Sealcath, LLC            Topic: NICHD

    PROJECT SUMMARY ABSTRACT During Phase ISealCathLLC will test the feasibility of its innovative Double Balloon CatheterDBCwhich the United States Utility Patent application was approved on Augustand is in the process of issuing a patentLicensed from the Medical University of South Carolinathis DBC will be commercialized in Phase III as the trademarked nameCephus Catheterwith targeted end users bein ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. CranialProgrammer: Image-Guided Directional Deep Brain Stimulation Programming Using Local-Field Potentials

    SBC: Nexeon Medsystems Puerto Rico Operating Company Inc            Topic: 105

    ABSTRACT The goal of this Uproposal is to develop and test CranialProgrammeran image guided programming tool forDD mapping of disease related neural signals over patient and device data for more efficient and effective programming of directional deep brain stimulationDBSsystemsDBS is an established treatment for advancedrefractory movement disorders used in overpatientsHowevermany patients receive ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Development of a User-friendly Bayesian Software Package: Proof of Concept

    SBC: Bayesic Technologies, LLC            Topic: 400

    PROJECT SUMMARY Essentially all researchers use statistical methods to determine whether observed results provide evidence to support their hypothesis or could be due to chance aloneFunctionality and ease of use are key factors dictating researcherschoice of statistical softwareSoftware packages using frequentist statistics have dominated the marketplaceCurrent trends in software development inclu ...

    STTR Phase I 2018 Department of Health and Human Services

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