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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 346: Targeted Radionuclide Therapy of Neuroendocrine Tumors Using 212Pb-octreotate Analogs

    SBC: RADIOMEDIX, INC.            Topic: NCI

    A peptide receptor radionuclide therapy (PRRT) using [177Lu]/[90Y]-labeled somatostatin analogs has been proven to induce objective response in 30-45% of patients with advanced/progressive neuroendocrine tumors (NETs). The complete response to beta-emitter PRRT is rare. This is due to the fact that NETs are diagnosed at late stage of disease; the NETs patients with remissions could develop resista ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 379: Extensible and Scalable Platform for Data Integration from Wearable Sensors to Generate Novel Analytics for Cancer Patients

    SBC: Litmus Health, Inc.            Topic: NCI

    The longterm objective of the Litmus Health platform is to allow researchers and clinicians to use data on cancer patients from wearables/sensors and smartphones. Collecting real-time, high-quality data from patients will transform care and clinical trials. Automating data collection, storage, analysis, and interpretation of data will result in better measurement of signs and symptoms and improved ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 372: Highly multiplexed selection of aptamers to hundreds of canine immunotherapy targets

    SBC: Base Pair Biotechnologies, Inc.            Topic: NCI

    The preclinical development of cancer therapeutics, including the recent trend and focus on cancer immunotherapies, is evolving from the traditional use of mouse models to the use of other animal models including canine, rat, and minipig. Each of these non-mouse models carries its own advantages and abilities to increase the clinical relevance of the model as compared to mouse models. Yet, the wid ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Developing informatics tools to make immunology research data Findable, Accessible, Interoperable and Reusable

    SBC: Melax Technologies, Inc            Topic: NIAID

    Immunological research produces complex datasets ranging from molecular level to individuals and populationsSeveral data repositories aim to serve the community by housing and making the datasets available for reuseHowevertheir usage is still limited due to lack of standardizations and accessibilityOne common issue is that the datasets in these repositories are not available to generalized search ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Inhaled Delivery of Clofazimine- A High Efficiency, Flow Independent, Targeted, Low Cost DPI

    SBC: Via Therapeutics, LLC            Topic: NIAID

    Multidrug resistance tuberculosisMDR TBis a global healthcare concern compounded by poor compliance associated with lengthy drug susceptible TBDS TBtreatment regimensClofazimineCFZis highly active against MDR TBbut oral use is limited by systemic toxicityhyperpigmentationGI effectsand QT prolongationInhalation of CFZ will overcome these limitations by achieving high local concentrations of drug an ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Aft Looking Spectrometer for Plume Characterization and Waking on Re-entry

    SBC: NANOHMICS INC            Topic: MDA16016

    Nanohmics proposes to develop a hyperspectral imager for aft-looking sensing of phenomenology associated with target vehicles.The payload is designed to operate with existing components and has no moving parts.The high spectral resolution will provide feedback for signature models and the spatial resolution will allow the spectral signatures to be associated with specific phenomena.Approved for Pu ...

    SBIR Phase II 2018 Department of DefenseMissile Defense Agency
  7. Advanced Rocket Trajectory Propagation Techniques

    SBC: NANOHMICS INC            Topic: MDA17T002

    High-fidelity trajectory propagators are fundamental to the simulation and analysis of launch vehicles, missiles, and satellites. Applications in fields ranging from missile threat analysis to flightpath optimization seek fast and accurate solutions to large numbers of trajectories in federated simulation environments. Due to their robustness, well-known properties, and straightforward implementat ...

    STTR Phase I 2018 Department of DefenseMissile Defense Agency
  8. Lightweight Structural Components of a Missile Body

    SBC: Texas Research Institute, Austin, Inc.            Topic: MDA17T004

    The Missile Defense Agency (MDA) has a need for weight-optimized solutions for future platforms of large missile structures.A significant weight reduction on these MDA platforms could increase maneuverability of the payload and allow the missile to launch additional kill vehicles.High temperature composite materials offer the means by which low cost and lighter weight missile structures can be ach ...

    STTR Phase I 2018 Department of DefenseMissile Defense Agency
  9. Methodologies for Cost-Effective Measurement of Dynamic Material Properties or Characterization of Materials under Dynamic Loads

    SBC: PROTECTION ENGINEERING CONSULTANTS LLC            Topic: MDA16T003

    Explosions and high-velocity impacts can create strain rates on the order of 105 to 107 s-1.To simulate these events, first-principles codes require material models that are valid at these loading rates.Currently, the amount of test data, material models and material constants for this strain rate range is extremely limited, and an innovative and cost-effective laboratory test procedure is needed. ...

    STTR Phase II 2018 Department of DefenseMissile Defense Agency
  10. High Speed Missile to Missile Communications

    SBC: CesiumAstro Inc.            Topic: MDA17001

    Missile-to-missile high speed communication can greatly enhance the operational effectiveness of the Ballistic Missile Defense System (BMDS) of the United States.Currently, information from the first interceptor is sent to the launch control and then from the launch control to the second interceptor. The round-trip signal latency decreases the likelihood of successful interception. The approach pr ...

    SBIR Phase I 2018 Department of DefenseMissile Defense Agency

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