Award Data

Abstract: “sHLA Protein Chip” The class I [A, B, C] and class II HLA proteins [DRB1, DQ, DP] comprise the heart of the inducible human immune system. For organ, marrow and stem cell transplantation, the development of serum-born antibodies against one or more of those many HLA proteins comprises the best and earliest test for transplant rejection. Because of the enormous medical importance of ...

Threaded fastening systems in vibrating environments require a secondary locking feature, augmenting primary locking provided by an applied preload, to prevent vibration-induced loosening. The secondary locking feature can be mechanical, prevailing torque-type, or an adhesive. Self-locking nutplates and inserts are often more expensive than adhesives, require retorquing or on-torque adjustments, a ...

Physical Sciences Inc. has successfully demonstrated the operational capability of a filament wound composite case designed to mitigate against slow cook-off, fast cook-off, bullet and fragment impact threats for solid rocket motor (SRM) systems. The implemented manufacturing, quality control and assurance processes enable production of small and large diameter motors to satisfy strategic and tact ...

Physical Sciences Inc. (PSI) proposes to utilize a ground-based simulation facility based upon its patented FAST technology to obtain critical data necessary to validate and extend the capabilities of the MDA’s high altitude plume code, SOCRATES-P, to model plume signatures with high fidelity. In Phase I PSI demonstrated the model validation approach by measuring the velocity dependent cross sec ...

Nanohmics proposes to develop a hyperspectral imager for aft-looking sensing of phenomenology associated with target vehicles.The payload is designed to operate with existing components and has no moving parts.The high spectral resolution will provide feedback for signature models and the spatial resolution will allow the spectral signatures to be associated with specific phenomena.Approved for Pu ...

Triton Systems, Inc. proposes to develop a method for efficiently running federated simulations of atmospheric and orbital rocket flight. Tritons proposed method will be able to get information between time steps without the need for interpolation and will significantly reduce the computational time needed to run Federated simulations.Approved for Public Release | 18-MDA-9522 (23 Feb 18)

High-fidelity trajectory propagators are fundamental to the simulation and analysis of launch vehicles, missiles, and satellites. Applications in fields ranging from missile threat analysis to flightpath optimization seek fast and accurate solutions to large numbers of trajectories in federated simulation environments. Due to their robustness, well-known properties, and straightforward implementat ...

The Missile Defense Agency (MDA) has a need for weight-optimized solutions for future platforms of large missile structures. A significant weight reduction on these MDA platforms could increase maneuverability of the payload and allow the missile to launch additional kill vehicles. High temperature composite materials offer the means by which low cost and lighter weight missile structures can be a ...

Explosions and high-velocity impacts can create strain rates on the order of 105 to 107 s-1. To simulate these events, first-principles codes require material models that are valid at these loading rates. Currently, the amount of test data, material models and material constants for this strain rate range is extremely limited, and an innovative and cost-effective laboratory test procedure is neede ...

A peptide receptor radionuclide therapy (PRRT) using [177Lu]/[90Y]-labeled somatostatin analogs has been proven to induce objective response in 30-45% of patients with advanced/progressive neuroendocrine tumors (NETs). The complete response to beta-emitter PRRT is rare. This is due to the fact that NETs are diagnosed at late stage of disease; the NETs patients with remissions could develop resista ...