Award Data

Reducing the violence of Slow Cook-Off (SCO) and Fast Cook-Off (FCO) to acceptable levels is of great interest to the Insensitive Munitions development. For example, the MIL-STD-2105C SCO test for Insensitive Munitions (IM) compliance requires a slow heating rate (3.3°C/hr) until reaction occurs whereby the ensuing reaction is characterized by degree of violence. A Type V (burn) reaction or bette ...

Project Summary We propose a two-arm adaptive Phase II clinical trial to evaluate ONC201, a selective antagonist of the G protein-coupled receptor (GPCR) dopamine receptor domain 2 (DRD2), in recurrent glioblastoma (GBM) and diffuse midline glioma associated with very poor prognoses and limited treatment options. DRD2 is overexpressed in high grade gliomas and controls Akt/ERK signaling pathways. ...

Abstract: “sHLA Protein Chip” The class I [A, B, C] and class II HLA proteins [DRB1, DQ, DP] comprise the heart of the inducible human immune system. For organ, marrow and stem cell transplantation, the development of serum-born antibodies against one or more of those many HLA proteins comprises the best and earliest test for transplant rejection. Because of the enormous medical importance of ...

There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

ORBIS proposes to Address SBIR DLA171-002 by developing efficient and effective processes to reverse engineer RPPOB Candidate Items. ORBIS has a wealth of experience in supporting DoD systems and components and is well suited to addressing the backlog of unsupported equipment .

The goal of the project is to develop a handheld instrument that detects, identifies, and categorizes radioactive sources based on gamma, thermal-, and fast-neutron signatures. Existing radioisotope identification devices (RIIDs) are typically biased toward gamma spectroscopy; some instruments may use an additional inefficient neutron counter in form of a He-3 tube. The recent development of mat ...

The goal of this Proposal is treatment of hemorrhage in SOCOM canines using a novel hemoglobin resuscitation fluid with oxygen carrying and plasma expansion properties (VIR-VET, a product of VirTech Bio). VIR-VET is designed to provide immediate hemodynamic stability and oxygenation to injured canines with blood loss. The product has advantages over traditional military fluid therapies: 1) As cell ...

Multi-Purpose Canines (MPCs) are an integral aspect of the US military. The continued expansion and use of these indispensable force multipliers in an intense, ever-changing and complex battlefield requires enhancing their innate capabilities in a timely manner. Additionally, canines have a relatively short life span, and considering the substantial training period that MPCs must undergo, their ef ...

The Navy has challenged the Small Business community to develop an improved skirt system for air cushion vehicles which reduces total ownership cost by increasing product life, decreasing manufacturing costs as well as installation and maintenance time, and improving reparability. The current system is primarily comprised of vulcanized polychloroprene rubber bonded to chemically coated nylon fabri ...

Triton Systems, Inc. proposes to develop a High Altitude Low Opening (HALO) parachute canopy with a single surface providing lift capability that leverages novel parachute design techniques and materials technology. The result is decreased weight, bulk, and maintenance resource burdens while achieving increased performance levels.