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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Non-Destructive Coercimetry Fracture Toughness Assessment for Steel Pipelines

    SBC: Innerspec Technologies, Inc.            Topic: 180PH1

    NON-DESTRUCTIVE COERCIMETRY FRACTURE TOUGHNESS ASSESSMENT FOR STEEL PIPELINES 3/8/2018 COMET’s main objective is to develop the first coercimetry-based fracture toughness assessment solution. Phase I will demonstrate the technical and economic feasibility of a non-destructive testing solution, based on coercivity metering, to assess material fracture toughness of steel pipelines; evaluating t ...

    SBIR Phase I 2018 Department of Transportation
  2. Demonstration of Image-Based Change Detection Using a Prototype Drone-Based Track Safety Inspection System

    SBC: Noble Drone Services, LLC            Topic: 180FR4

    Demonstration of Image-Based Change Detection using a Prototype Drone-Based Track Safety Inspection 3/16/2018 Today’s prevailing methods of visual track inspection tend to be expensive, disruptive to operations, and have potential to be less thorough than preferred. Machine vision technology emerged in the rail sector over a decade ago to help alleviate these concerns; however, due to the un ...

    SBIR Phase I 2018 Department of Transportation
  3. Resilient Wayside Structures to Reduce Severity of Passenger Equipment Collisions and Derailments

    SBC: PROTECTION ENGINEERING CONSULTANTS LLC            Topic: 171FR3

    Proposal title: Resilient Wayside Structures to Reduce Severity of Passenger Equipment Collisions and Derailments Additional passenger fatalities/injuries can occur during derailments involving interaction with wayside structures. Analogously, automobile fatalities often result from interaction of vehicles with roadside structures; personnel hazard reduction is a key design criterion for roadsid ...

    SBIR Phase II 2018 Department of Transportation
  4. Development of Taenia Solium Specific Aptamers for Diagnostic Assays

    SBC: Lynntech Inc.            Topic: ODCDC

    The parasitic tapeworm Taenia solium causes two diseasestaeniasisadult worm in the intestineand cysticercosistissue infection by the cystwhich can lead to seizuresThe Tsolium life cycle involves both humans and pigshowever humans are the only definitive host for the adult Tsolium tapewormDiagnosing people infected with the adult worm is a critical step toward eliminating Tsolium althogetherHowever ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Topic 346: Targeted Radionuclide Therapy of Neuroendocrine Tumors Using 212Pb-octreotate Analogs

    SBC: RADIOMEDIX, INC.            Topic: NCI

    A peptide receptor radionuclide therapy (PRRT) using [177Lu]/[90Y]-labeled somatostatin analogs has been proven to induce objective response in 30-45% of patients with advanced/progressive neuroendocrine tumors (NETs). The complete response to beta-emitter PRRT is rare. This is due to the fact that NETs are diagnosed at late stage of disease; the NETs patients with remissions could develop resista ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Topic 379: Extensible and Scalable Platform for Data Integration from Wearable Sensors to Generate Novel Analytics for Cancer Patients

    SBC: Litmus Health, Inc.            Topic: NCI

    The longterm objective of the Litmus Health platform is to allow researchers and clinicians to use data on cancer patients from wearables/sensors and smartphones. Collecting real-time, high-quality data from patients will transform care and clinical trials. Automating data collection, storage, analysis, and interpretation of data will result in better measurement of signs and symptoms and improved ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Topic 375: Novel Diagnostic Imaging Modality for Monitoring Tumor Responses to a Hyperthermia Immunotherapy (Moonshot)

    SBC: Imago Systems, Inc.            Topic: NCI

    Immunotherapies have been emerging in the past decades as powerful approaches for cancer treatment. However, the immune system is complex, and therapy efficacy is substantially affected by the tumor microenvironment. For this reason, it is currently difficult to visualize tumor response and predict therapeutic efficacy. In this Contract, Imago Systems, Inc., a company with substantial experience i ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Topic 372: Highly multiplexed selection of aptamers to hundreds of canine immunotherapy targets

    SBC: Base Pair Biotechnologies, Inc.            Topic: NCI

    The preclinical development of cancer therapeutics, including the recent trend and focus on cancer immunotherapies, is evolving from the traditional use of mouse models to the use of other animal models including canine, rat, and minipig. Each of these non-mouse models carries its own advantages and abilities to increase the clinical relevance of the model as compared to mouse models. Yet, the wid ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. A system to detect fall occurrence and location in hospital settings

    SBC: BARRON ASSOCIATES, INC.            Topic: NIA

    Fall detectionassessmentand prevention is a challenging issue across the care continuumDespite wide recognition as a considerable problemfall related injuries are still the most frequently reported adverse events in hospital inpatient settingswithof patients falling at least once during their stayAccording to the Agency for Healthcare Research and Quality reportstoof falls result in injuryIn the U ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Polyketide chiral building blocks and biocatalysts

    SBC: Coala Biosciences            Topic: 300

    PROJECT SUMMARY As with most synthetic chemistsCoALA Biosciences is inspired by naturally occurring polyketide assembly lineswhich synthesize diverse medicines through reactions that generate carbon carbon bonds and precisely set stereocentersIf chemists were to collaborate with the enzymes in these assembly linessyntheses of compounds in the drug discovery process would be greatly accelerated and ...

    SBIR Phase I 2018 Department of Health and Human Services
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