Award Data

Maximizing the effectiveness whilst simultaneously minimizing the toxicity of antimicrobial agents is the most important step in any effective infectious disease treatment regimen, however, escalating resistance, lack of novel antibiotics and complexity in patient populations has rendered many traditional dosing regimens ineffective. To compound the issue, some antimicrobials, such as aminoglycosi ...

The main objective of this Phase II.2 DARPA SBIR proposal is to develop a robust and reliable electrical connection strategy for softening implantable electrode arrays and industry standard connectors for use in chronic animal models at research facilities throughout the world. The Phase II.2 base period consists of two tasks: 1) to connect softening neural interfaces to wire-based and flexible po ...

Recent advances in deep sub-threshold analog and digital electronics have created a class of intelligent electronics capable of power consumption levels as low as 10 nanowatts while in the sensor’s asleep-yet-aware phase of Near Zero Power RF and Sensor Operations (N-ZERO). The sub-threshold circuits require power supply voltages typically in the 0.3 to 0.7 V range, yet the voltages of current c ...

A staggering number of microbes on Earth (99%) are not culturable using standard laboratory methods. These microbes are called “unculturable”. Microbes not grown and studied in laboratories are uncharacterized and may be a source of useful biological products and molecules. Unculturables have been found in many sample types and environments. Furthermore, characterization of these organisms wil ...

In Phase II of AQUIRE, we will develop a prototype document background generation and management system that can be used by analysts and decision makers to access information gathered from a wide variety of unstructured sources about entities, relations, and complex situations. This system will be able to (1) construct topically organized entity corpora which are automatically supplemented with st ...

A significant challenge in extracting event attributes from unstructured text is that events possess a wide array of attributes which affect decision making. In a single document, an author may describe events that have happened (realis), did not happen or could have happened (irrealis), and that may happen in the future. They may describe events which reflect a generic class of occurrences, or a ...

Chronically implanted neural electrodes are used to treat various neurological and neuropsychological disorders and for brain-machine interfaces used to control advanced prosthetics. Powering these systems with batteries is risky due to loss of power and energy over time, necessitating additional surgery, creating a lapse in treatment and additional risks from potential exposure to toxic material. ...

Lynntech is developing an energy efficient desalination technology for small scale applications.The energy requirements for traditional desalination processes such as reverse osmosis can be as high as 30 Wh/L when producing potable water from seawater at small scale production rates.During the Phase I project, Lynntech developed a novel desalination technology and demonstrated an energy efficiency ...

High-performance, high-speed analog-to-digital converters (ADC) are becoming essential building blocks in many applications including wireless modems, optical communications, test equipment such as real-time oscilloscopes, and high-energy particle physics (e.g., CERN), to name a few. While several ADC architectures have been proposed, time-interleaved (TI) SAR (Successive Approximation Register) A ...

The objective of this proposal is to fully evolve a plug cluster aerospike design, moving from state-of-the-art computational analysis to manufacturing, ground testing, and then a full stage integration ground test. If the phase II option is exercised, the aerospike would be flight tested as well. The computational analysis is already well underway, with numerous studies producing results that hav ...