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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Proximity-Based Fire Alert Notifications for Hearing Impaired

    SBC: KnewTek            Topic: na

    This project develops smoke detector hardware and an associated smartphone application which, upon detection of an environmental threat (e.g., a fire), automatically pushes alert notifications directly to individuals who are Deaf or hard of hearing via a cellular telephone or smart device application. The alert notifications are transmitted to telephones or smart devices within proximity of the sm ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Development of an Oral Acidic Mammalian Chitinase Inhibitor to Treat Asthma

    SBC: ONCOARENDI THERAPEUTICS LLC            Topic: NHLBI

    Approximatelymillion Americans suffer from asthmawhich leads to aboutdeaths per yearand is responsible for estimated annual total direct and indirect costs of $billionDespite the existing treatments for asthmapredominantly combinations of inhaledagonists and corticosteroidsCSsthere remains a significant unmet medical need for new therapies which address two key issuesapproximatelyof patients are i ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. An antigen-detection assay to diagnose Babesia microti infection

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    Project Summary Human babesiosis is a malaria like multisystem disease caused primarily by Babesia microtian emerging apicomplexan parasite that infects and develops within human erythrocytesThe parasite is transmitted to humans by the tick vector Ixodes scapularis and can also be introduced through blood transfusionInfection can cause flu like symptomsand severe infection can be fatalin particula ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Development of a hybrid transcatheter mitral valve replacement and repair device

    SBC: Dura LLC            Topic: NHLBI

    PROJECT SUMMARYMitral regurgitationMRis the most prevalent valvular heart disease in the U Saffecting approximatelyof the populationThere aremillion patients in the US with moderate to severe MR requiring treatmentHoweveronly approximatelypatients in the U Sundergo surgery for MR each year due to concerns about procedural complexity and patient safetyThere is great enthusiasm among the heart valve ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Bioengineered skin microbiota for cutaneous mitigation of Netherton Syndrome

    SBC: Azitra Inc.            Topic: NIAMS

    PROJECT SUMMARY Current treatment options for many skin diseases especially rare diseases fail to address the underlying causative pathophysiologiesIn the case of genetic mutations that cause loss of function mutationssupplementing the missing protein is a viable approach to treatmentHoweverdelivery of functional protein to the target keratinocytes presents a significant challengemoreoverthe cost ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. MPS I Skeletal Disease Therapy with Novel Lectin-delivered Replacement Enzyme

    SBC: Biostratagies, LC            Topic: NIAMS

    BioStrategies LC is developing the plant galactose binding lectinRTBas an enzyme carrier capable of expanding delivery of enzyme replacement therapiesERTstohardto treatorgans and tissues such as boneThe rare lysosomal disease mucopolysaccharidosis IMPS Iis a progressive multisystem disorderwhich presents with significant skeletal abnormalities that play a major role in patient disease progressionM ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Wireless Movement Sensing System for People with Severe Disabilities

    SBC: INVOTEK, INC.            Topic: NIDCD

    Abstract The ability of people with severe physical impairment to participate in family lifecommunicationworkor recreation is severely restricted without access to assistive technologyATYetas disability severity increasesso does the challenge to findingan access movement that a person can perform to control AT andan access technology that can detect the access movementWe propose to create a wirele ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Enhancing Immunogenicity of VLV-Based Vaccines for Treatment of Chronic HBV

    SBC: Carogen Corporation            Topic: 300

    PROJECT SUMMARY ABSTRACT The host T cell response to HBV is vigorous and multi specific in acutely infected patients who clear the virusbut it is weak and more narrowly focused in those who become chronically infectedThereforealthough the human immune response is capable of eliminating the infectionit often fails to do soTherapeutic immunization to induce an immune response sufficient to control t ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. A Double Balloon Catheter for the Treatment of Intussusception in Children

    SBC: Sealcath, LLC            Topic: NICHD

    PROJECT SUMMARY ABSTRACT During Phase ISealCathLLC will test the feasibility of its innovative Double Balloon CatheterDBCwhich the United States Utility Patent application was approved on Augustand is in the process of issuing a patentLicensed from the Medical University of South Carolinathis DBC will be commercialized in Phase III as the trademarked nameCephus Catheterwith targeted end users bein ...

    SBIR Phase I 2018 Department of Health and Human Services

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