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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Project isoPTE: isothermic post-traumatic epilepsy miRNA biomarker detection

    SBC: FYR DIAGNOSTICS, LLC            Topic: 999

    Project Summary Acquired epilepsy results from acute brain injurysuch as traumatic brain injuryTBIAcquired epilepsy is a major public health issue with inadequate treatment and diagnostic optionsThere are no biomarkers that assist in the prediction or diagnosis of acquired epilepsyProject isoPTE will use two animal models of epilepsy to determine whether plasma microRNAmiRNAbiomarkers can predict ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a lead cyclic-PDZ-Enhancer drug for Anxiety and Depression

    SBC: Aingeal, LLC            Topic: 101

    Major depressive disorder is a debilitating mood disorder that affectsof US adults in their lifetimecosting the U Seconomy more than $billion a yearDrugs that increase monoaminergic signaling are the mainstay of depression therapybut have a delayed onset of action and are only effective in aboutof affected patientsAberrant brain derived neurotrophic factorBDNFsignaling has been proposed to underli ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Discovery of NaV1.7 Inhibitors for the Treatment of Pain

    SBC: Siteone Therapeutics, Inc.            Topic: 105

    PROJECT SUMMARY The objective of our program is to develop a safe and effective nonopioid analgesic for the treatment of neuropathic painsuch as pain associated with chemotherapy induced peripheral neuropathythat targets an isoform of the voltage gated sodium ion channelNaVVoltage gated sodium channels are involved in the transmission of nociceptive signals from their site of origin in the periphe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. An integrated web interface for cloud-based computational reproducibility using the ENCODE analysis pipeline architecture

    SBC: xD Bio, Inc.            Topic: 172

    Project SummaryAbstract This project will develop and test a publicly available web interface for executing and monitoring genomic data analysis pipelines described by the Workflow Description LanguageThe interface will be hosted on Truwl TMhttpstruwl comxD Bio s TMcommunity oriented genomic data analysis methods sharing web applicationExecuting pipelines will leverage the reproducibility framewor ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Topical selective T-type blockers for the treatment of pruritus

    SBC: Dermaxon LLC            Topic: NIAMS

    Project SummaryAbstractPruritusalso called itchis the most frequent dermatological symptom in the US with up toof Americans being affectedPruritic stimuli are detected by a subset of nociceptive neuronspruriceptorswhich fire action potential in response to peripheral activation by THor THmolecules induced by chronic inflammatory skin diseases such as ichthyosisprurigo nodularisand hidradenitis sup ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Fourth Trimester- A web-based tool for Postpartum Care to Address the Needs of Underserved Women

    SBC: Orange Square Design, Inc.            Topic: NIMHD

    PROJECT SUMMARY ABSTRACT In the United Statesthe postpartum period is a critical time for both maternal and child healththe mortality rate is the highest among other developedhigh income countries and more than half of all maternal deaths occur postpartumfrom one day to one year after birthThis poor outcome is linked to the racial and ethnic disparities that disproportionately effect black women w ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Novel High-Resolution Scintillation X-ray Detectors for Digital Dentistry

    SBC: NGS Detectors LLC            Topic: NIDCR

    Project SummaryNovel High Resolution Scintillation X ray Detectors for Digital Dentistry The transition from traditional film to digital X ray detectors has resulted in significant improvements across many areas for dental X ray imaging ranging from decreased wait timesimproved logistics and even lower radiation dose ratesOne significant drawback remains with digital X ray imaging howeverwhich is ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. An optimized screening platform for identifying and quantifying biased agonists as drugs for the treatment of Opioid Use Disorder

    SBC: Montana Molecular LLC            Topic: NIDA

    ! Project Summary Millions of Americans today have an opioid use disorderOUDMillions more misuse opioidsand the crisis continues to growThe goal of this proposal is to speed the discovery of non addictive analgesics by providing drug discovery teams with simplermore robustmore quantitativeassays for agonist biasDriven by the urgency of the problem we are seeking Fast Track support to create new as ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Developing EXP-1801 as an imaging agent to quantify pain and analgesia

    SBC: Expesicor Inc            Topic: NINDS

    Summary Abstract There are currently no tools available that can objectively measure painHistoricallypain in humans has been measured using subjective ratings to determine presence and severityIn animal modelspain is measured by semi quantitative assays that rely on the observation of pain behaviorsThough usefulthe inherently subjective nature of these measures has hampered both research and treat ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Modeling drug-refractory epilepsy with the KaL method

    SBC: Expesicor Inc            Topic: NINDS

    Epilepsy is a common neurological disorder that is characterized by recurrentspontaneousseizuresEpilepsy is a major public health issue with inadequate treatment optionsOvermillion people worldwide have epilepsyThis is more than cerebral palsymultiple sclerosisandParkinson s disease combinedAlthough more than two dozen antiseizure drugsASDsexistapproximately one third of patientsovermillionsuffer ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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