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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Implantable Noise-Based Sensory Enhancement Devices

    SBC: AFFERENT CORPORATION            Topic: N/A

    Stochastic resonance (SR) is a counterintuitive phenomenon in which slight amounts of noise imparted to a system actually increase its sensitivity to weak stimuli. SR has been shown to produce a demonstrable effect in human sensory cells. In both healthy young and clinical subjects - elderly, diabetics, and stroke sufferers - a notable increase in tactile and proprioceptive sensitivity is seen whe ...

    SBIR Phase I 2001 Department of Health and Human Services
  2. ENHANCING THE TACTILE SENSE USING MECHANICAL NOISE

    SBC: AFFERENT CORPORATION            Topic: N/A

    Stochastic resonance (SR), a counterintuitive phenomenon in which slight amounts of environmental noise actually increase the discernability of signals or stimuli, produces a demonstrable effect in human sensory cells. In both healthy young and clinical subjects- elderly, diabetics, and stroke sufferers-a significant increase in tactile and proprioceptive sensitivity is noted when electrical or me ...

    SBIR Phase I 2001 Department of Health and Human Services
  3. Restoring Diabetic Tactile Sense with Mechanical Noise

    SBC: AFFERENT CORPORATION            Topic: N/A

    Stochastic resonance (SR) is a counterintuitive phenomenon in which slight amounts of noise imparted to a system actually increase its sensitivity to weak stimuli. SR has been shown to produce a demonstrable effect in human sensory cells. In both healthy young and clinical subjects-elderly, diabetics, and stroke sufferers-a notable increase in tactile and proprioceptive sensitivity is seen when el ...

    SBIR Phase I 2001 Department of Health and Human Services
  4. Composite Supports for High Throughput Chromatography

    SBC: CHELATECH, INC.            Topic: N/A

    N/A

    SBIR Phase I 2001 Department of Health and Human Services
  5. COMPOSITE SUPPORTS FOR RAPID POLYNUCLEOTIDE SYNTHESIS

    SBC: CHELATECH, INC.            Topic: N/A

    DESCRIPTION (applicant's abstract): Modern DNA synthesis methods make use of porous solid phase supports that are used to immobilize the first base in the sequence. This process is inherently inefficient, because solutes and solvent flowing through a column of porous media prefer the path of least resistance. Flow naturally goes around the particles, rather than throug ...

    SBIR Phase I 2001 Department of Health and Human Services
  6. OPTIMAL ISLET MATRIX FOR IMMUNOISOLATED TRANSPLANTS

    SBC: Cytotherapeutics, Inc.            Topic: N/A

    THE LONG TERM OBJECTIVE OF THIS RESEARCH IS THE DEVELOPMENT AND INTRODUCTION INTO CLINICAL PRACTICE OF AN EFFECTIVE, AND BIOCOMPATIBLE IMPLANTABLE-HYBRID- ARTIFICIAL-PANCREAS WHICH IS CAPABLE OF SIGNIFICANT IMPROVEMENT IN THERAPY OF INSULIN DEPENDENT DIABETES. THE SPECIFIC AIM OF THIS PROJECT IS TO INVESTIGATE METHODS OF IMPROVING THE VIABILITY AND FUNCTION OF MACRO-ENCAPSULATED ISLETS. DEVELOPMEN ...

    SBIR Phase I 1991 Department of Health and Human Services
  7. Epitope driven HPV Vaccine Targeting Dentritic Cells

    SBC: EPIVAX, INC.            Topic: N/A

    Human Papilloma Virus (HPV) types 16 and 18 are detected in roughly 70% of all invasive cervical tumors. Among cytologically normal women, detection of HPV infection by PCR has been shown to increase the subsequent risk of cervical cytologic abnormalities by 12 fold, suggesting that effective vaccines (preventive/therapeutic) for HPV infection would be a useful medical advance in the battle agains ...

    SBIR Phase I 2001 Department of Health and Human Services
  8. Diagnostic Reagents for Emerging Infectious Diseases

    SBC: EPIVAX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): West Nile virus (WNV) is a flavivirus commonly found in Africa, West Asia, and the Middle East. The virus was introduced into the United States in 1999. Case-fatality rates during the 1999-2000 U.S. epidemics ranged from 3 percent to 15 percent and were highest in the elderly. The virus is expected to over-winter during ...

    SBIR Phase I 2001 Department of Health and Human Services
  9. ENHANCED DNA MICROARRAY PERFORMANCE WITH GAPPED PROBES

    SBC: GENESPECTRUM            Topic: N/A

    The goal of this project is to develop a more powerful and robust system for the sequencing and analysis of DNA by hybridization to microarrays. Our conceptually novel approach is based on a new probe design and sequence reconstruction algorithm which has been demonstrated by computational modeling to provide higher information density on a DNA hybridization chip. The Human Genome Project is provi ...

    SBIR Phase I 2001 Department of Health and Human Services
  10. Software Relating Genes to Disease and Clinical Outcomes

    SBC: Golden Helix, Inc.            Topic: N/A

    DESCRIPTION (Applicant's abstract): The development of a software system is proposed that will combine statistical theory, computer science algorithms, and genetics expertise to take advantage of the great influx of data generated by both the study of the human genome and the creation of inexpensive genotyping techniques. This software will elucidate the complex relatio ...

    SBIR Phase I 2001 Department of Health and Human Services
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