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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. INTERACTIVE TECHNOLOGIES TO MODIFY CANCER RISK BEHAVIORS

    SBC: ABACUS HEALTH SOLUTIONS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant)The major goals of this revised, SBIR Phase II application for the combined R25/R44 mechanism to complete development of a multi-media, cancer risk behavior modification intervention and to conduct a randomized controlled trial with low income patients and their primary care physicians to assess its impact. The prototype system of tools created in the Phase I is ...

    SBIR Phase I 2002 Department of Health and Human Services
  2. REAL-TIME DETECTION OF BACTERIA IN PLATELET CONCENTRATES

    SBC: BCR DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (Provided by applicant): BCR Diagnostics, Inc. (BCR) proposes to demonstrate the feasibility of adapting its LEXSAS (Label-free Exponential Signal-Amplification System) technology for real-time bacteriologic analysis of blood products intended for transfusion. The LEXSAS technology is unique in that it uses spores as ultrasensitive nanodevices capable of emitting fluorescent light sign ...

    SBIR Phase I 2002 Department of Health and Human Services
  3. TUBERCLE BACILLI BINDING TO HOST CELLS: VACCINE DESIGN

    SBC: LIGOCYTE PHARMACEUTICALS, INC.            Topic: N/A

    Three million people die each year from tuberculosis (TB) in spite of the use of the existing anti-mycobacterial antibiotics and the BCG vaccine. Clearly, a better vaccine and better ways to treat TB are needed. The purpose of this STTR Phase I feasibility study is to evaluate Mycobacterium tuberculosis-binding interactions with several human cell types and pathogen recognition molecules. Pathogen ...

    STTR Phase I 2002 Department of Health and Human Services
  4. GROUP B STREPTOCOCCAL PEPTIDE MIMETIC VACCINE

    SBC: LIGOCYTE PHARMACEUTICALS, INC.            Topic: N/A

    Group B streptococcus (GBS) causes invasive infections of newborns, pregnant women and adults with underlying medical conditions, such as diabetes or cancer. Despite antibiotic treatment, estimated case fatality rates of 5-20% in neonates and 15-32% in adults establish the prevention of GBS infections as a public health priority. Peptide immunogens that mimic the structure of GBS capsular polysach ...

    SBIR Phase I 2002 Department of Health and Human Services
  5. TAXOL PRODUCTION WITH A NOVEL FERMENTATION REACTOR

    SBC: RESODYN CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The specific innovation proposed for this Phase I project will combine an advanced, novel low-frequency sonic energy technology with the production of fungal secondary metabolites of pharmaceutical importance. The Phase 1 project will demonstrate the use of a novel fermentation reactor to provide improved agitation and aeration during the in vitro cultivation o ...

    SBIR Phase I 2002 Department of Health and Human Services
  6. MULTIFUNCTIONAL DENDRITIC TETHERS FOR BIOSENSOR DEVICES

    SBC: MPA Technologies, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Our lack of rapid detection protocols for bioterrorism agents, pathogenic agents. and affordable, easy to operate devices suitable for deployment in field environments has been demonstrated by the confusion and the number of deaths due to exposure to anthrax spores in the past several months. It is chilling to envision the potential chaos that results from sim ...

    SBIR Phase I 2002 Department of Health and Human Services
  7. MAMMALIAN HEPATOCYTES, A SOURCE OF THERAPEUTIC PROTEINS

    SBC: MULTICELL TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The safe and efficient production of novel therapeutic proteins represents an expanding market of the biopharmaceutical industry that is fueled by the recent completion of the Human Genome Project and by rapid technological advances in the field of proteomics. Although many of these therapeutic proteins will be mass-produced by recombinant technology, there wil ...

    SBIR Phase I 2002 Department of Health and Human Services
  8. INDIVIDUALIZED EXPERT SYSTEMS FOR WEIGHT MANAGEMENT

    SBC: Pro-Change Behavior Systems Inc            Topic: N/A

    DESCRIPTION (Provided by applicant): The prevalence of overweight and obesity has increased dramatically over the last two decades. Overweight and obesity, the second leading preventable cause of death, poses a major public health challenge in that it increases the risk of chronic diseases, including coronary heart disease, and all-cause mortality. Clinic-based programs for weight management are c ...

    SBIR Phase I 2002 Department of Health and Human Services
  9. EXPERT SYSTEM INTERVENTION--DOMESTIC VIOLENCE OFFENDERS

    SBC: Pro-Change Behavior Systems Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Male-to-female partner violence poses a major threat to the physical and emotional well being of women. Research assessing the efficacy of court-mandated domestic violence treatment programs has yielded disappointing results. A major problem with mandated treatment is that it tends to be standardized and 'one-size-fits-all,' neglecting individual differences in ...

    SBIR Phase I 2002 Department of Health and Human Services
  10. THERAPEUTIC USE OF INTER-ALPHA INHIBITOR IN SEPSIS

    SBC: PROTHERA BIOLOGICS, LLC            Topic: N/A

    The primary goal of this proposed research is targeted towards demonstrating the commercial utilization of human plasma derived inter- alpha inhibitor proteins (IaIp) an effective therapy of sepsis. IaIp are serine protease inhibitors found normally at high levels in human plasma. The fact that no person with complete absence of IaIp has ever been detected suggests an essential physiological role ...

    SBIR Phase I 2002 Department of Health and Human Services

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