Award Data

DESCRIPTION (provided by applicant) Every year millions of hearing tests are conducted in the U.S. for a variety of reasons, including diagnosis of ear disease, evaluation of communicative function, monitoring effects of noise and ototoxic medications. prospective research studies, and fitting of hearing aids. Although there is a "standard" hearing test method, th ...

DESCRIPTION: The number of persons in the United States with dementing disorders, now between 4-5 million, will quadruple in 50 years. One consequence of the progressive nature of dementia is that family caregivers must assume the role of primary decision makers. This Phase I proposal will develop an Internet-based prototype and companion CD-ROM Dementia Decision-making Guide based ...

An optoelectronic integrated circuit combines intersubband infrared and wide bandgap ultraviolet absorption in one pixel with an integrated output. Currently, QWIPs employ a doped multiquantum well structure sandwiched between n+ type contacts. Thequantum barrier limited dark current flow requires cooling to 60K for BLIP performance and the QWIPs are hybrid bonded to a Si ROIC for electrical ac ...

This proposal encompasses a facile method for generating transgenic chickens. Traditionally, the approach to accomplish this has been to target the avian egg or embryo for gene insertion using either viral or 'standard' plasmids as vectors. In contrast,our proposed method introduces two new features, i.e. (1) novel transposon DNA vectors and (2) injection of DNA into the testes of immature males. ...

The goal of this Phase I proposal is to develop a synthetic, low cost, and benign simulant for biowarfare agents (BWA) to be used in the testing of standoff sensors. Orono Spectral Solutions Inc. (OSS) has performed preliminary work leading to the identification of benign ingredients that, when combined in a predefined mass ratio, mimic UV-Vis and infrared signatures of BG spores. This work was pe ...

The overall goal of this Phase I project is to demonstrate the feasibility of an infrared transparent, micro-fluidic sampling system that will lead to a field-deployable detection system capable of detecting low ppb levels of chemical warfare (CW) agents in water. To accomplish this goal, the proposed detection system will combine high surface area, organically modified mesoporous oxide absorptiv ...

Highly scalable parallel random number generators (RNGs) will be developed, evaluated and implemented for use in high performance computing on thousands of multi-core processors and general purpose graphics processing units. The main contributions are: (a) design and implementation of new parallel test methods that capture the inter-stream correlations exhibited in practice and complement the curr ...

DESCRIPTION (provided by applicant): Advanced Medical Electronics Corp, in collaboration with the Johns Hopkins University School of Medicine, proposes to develop a hardware/software platform suitable for administering a variety of tests and survey instruments to underserved populations in settings that can range from living rooms to libraries, community centers to nursing homes, and from inner ci ...

DESCRIPTION (provided by applicant): The advent of target-based drug discovery, assisted by advances in x-ray crystallography and NMR, has left pharmaceutical companies suffering both from too much and too little information: too much information in the sense that the early push for target discovery has left pharma's RandD drowning in potentially relevant targets and drug candidates; too little in ...

DESCRIPTION (provided by applicant): This STTR application is to develop and test for eventual clinical use a new strategy for tumor specific anticancer drug delivery. The technology, Clostridia-directed enzyme prodrug therapy, or CDEPT, exploits the fact that certain non-pathogenic bacteria of the Clostridia genus, which only grow in the absence of oxygen (hypoxia), colonize the hypoxic and necr ...