List

Project Summary This Phase II SBIR project seeks to demonstrate that noveltargetable nanoparticles can delivery therapeutic substances to human tumor cells and reduce tumor burden in cancerThe concept for these nanoparticles is based on the hybrid polymerized liposome nanoparticleHPLNthat displays functional antibodies that target tumor cell surface markersThe therapeutic cargos are encapsulated c ...

The proposal seeks to initiate the development of a tetraethyl orthosilicate based thixotropic antibiotic delivery systems for the treatment of otitis externa and prevention of malignant otitis externaThis study will set the foundation for the development of point of caresingle application thixotropic drug delivery platform technologies for otic therapeutics PROJECT SUMMARY Outer ear infectionsoti ...

Summary Abstract Many diseases of the brain involve cellular stressEarly in lifethe Zika virus triggers stress in neural progenitor cells causing microcephalyMuch later in life the mutant proteins produced in Parkinsonandapos s and Huntingtonandapos s diseaseas well as ALSand Alzheimerandapos s all produce cellular stress leading to the slow neurodegeneration that occurs over many yearsTypically t ...

PROJECT SUMMARY The absence of safe and effective strategies for the management of ocular pain is motivating the development of a novel topical drug suitable for patient self administrationConventional local anestheticssuch as proparacaineinhibit voltage gated Naion channelsNaVand are highly effective for the management of ocular pain in acutein office settingsHoweverthese agents are short acting ...

Project SummaryAbstract DermaXon s project goal is to develop efficacious substrate based and highly selective inhibitors of CYPsthe enzymes responsible or retinoic acidRAmetabolism in the epidermisfor the topical treatment of ichthyosisThis approach will provide a therapeutic advantage in ichthyosis without the potential adverse effects mediated by non targeted Pinhibitionassociated with previous ...

Abstract The goal of this project is to develop a commercial analysis software platform that features the ability to detect and interpret copy number variantsCNVsand other types of structural variationsSVsfrom short read NextGen SequenceNGSdata to enable comprehensivewidely accessibleand economical genetic testingThis capability is key in clinical and research applicationsFor examplecurrently clin ...

Novel and effective techniques for imparting STEM based knowledge and concepts are increasingly in demand as our world becomes progressively computerized and complexWhile traditional teaching approaches have worked well in the past for many areas of studyresearch has shown that traditional teaching methods may diminish student engagement in scientific studieswhich are especially dynamic and consta ...

Project Summary The long term goal of this Phase II SBIR project is to develop a commercially viable ultrasound contrast reagentUCRthat will allow the noninvasive identification and treatment of newly forming abdominal adhesions after surgerySuccessful implementation would have significant impact because we would both improve patient post surgical monitoring and considerably reduce the cost of adh ...

For this Phase 1 Small Business Technology Transfer (STTR) project, Blackmore Sensors and Analytics and university partner Montana State University will investigate the use of coherent frequency modulated continuous wave (FMCW) ladar/lidar and digital holography techniques for improved performance of active imaging through fog. Coherent range, Doppler, and polarization selective digital holography ...

Project SummaryAbstract Paclitaxel is widely used throughout the field of oncology with indications for the treatment of a number of solid tumorsThe most commonly reported neurotoxic effect of paclitaxel is peripheral sensory neuropathy which often limits the dose and frequency of paclitaxel treatmentNeuropathic pain management is currently aimed only at reducing symptoms and treatment of chronic ...