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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. NV103: Antibody Conjugated Nanoparticle for Ewing Sarcoma Targeted Therapy

    SBC: NanoValent Pharmaceuticals, Inc.            Topic: 102

    Project Summary This Phase II SBIR project seeks to demonstrate that noveltargetable nanoparticles can delivery therapeutic substances to human tumor cells and reduce tumor burden in cancerThe concept for these nanoparticles is based on the hybrid polymerized liposome nanoparticleHPLNthat displays functional antibodies that target tumor cell surface markersThe therapeutic cargos are encapsulated c ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Single application thixotropic antibiotic delivery systems for otitis externa

    SBC: Promiliad Biopharma Incorporated            Topic: NIDCD

    The proposal seeks to initiate the development of a tetraethyl orthosilicate based thixotropic antibiotic delivery systems for the treatment of otitis externa and prevention of malignant otitis externaThis study will set the foundation for the development of point of caresingle application thixotropic drug delivery platform technologies for otic therapeutics PROJECT SUMMARY Outer ear infectionsoti ...

    STTR Phase I 2018 Department of Health and Human Services
  3. RoboHear device:advanced haptic technology that allows deaf to understand speech

    SBC: FAUXSEE INNOVATIONS LLC            Topic: NIDCD

    Project Summary AbstractIn the USthere areM adults with hearing difficultiesand overM are profoundly deafi eunable to hear speech or participate in a normal conversationGloballyM people have disabling hearing lossDeafness can be debilitating and greatly affects an individual s socialeducational and occupational prospectsCurrentlythe major medical treatment for deafness is a cochlear ear implantThi ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Live Cell Assays to Identify and Interrogate Stressed Neurons in Models of Neurodegenerative Disease.

    SBC: Montana Molecular LLC            Topic: 105

    Summary Abstract Many diseases of the brain involve cellular stressEarly in lifethe Zika virus triggers stress in neural progenitor cells causing microcephalyMuch later in life the mutant proteins produced in Parkinsonandapos s and Huntingtonandapos s diseaseas well as ALSand Alzheimerandapos s all produce cellular stress leading to the slow neurodegeneration that occurs over many yearsTypically t ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Seromic Mucin Signature for the Early Diagnosis of Pancreatic Cancer

    SBC: Sanguine Diagnostics And Therapeutics, Inc.            Topic: 102

    ABSTRACT Pancreatic cancerPCis an extremely aggressive malignancy with one of the worst prognoses of all cancersWith marked resistance to chemoand radiotherapiessurgery is the only curative optionIn patients with localized diseasecomplete surgical resection provides five year survival rate ofHoweverrtof patients are diagnosed with unresectable primary tumors and or distant metastasisThe major caus ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. GUANIDINIUM DERIVATIVES FOR THE TREATMENT OF OCULAR PAIN

    SBC: Siteone Therapeutics, Inc.            Topic: N

    PROJECT SUMMARY The absence of safe and effective strategies for the management of ocular pain is motivating the development of a novel topical drug suitable for patient self administrationConventional local anestheticssuch as proparacaineinhibit voltage gated Naion channelsNaVand are highly effective for the management of ocular pain in acutein office settingsHoweverthese agents are short acting ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. Wireless Movement Sensing System for People with Severe Disabilities

    SBC: INVOTEK, INC.            Topic: NIDCD

    Abstract The ability of people with severe physical impairment to participate in family lifecommunicationworkor recreation is severely restricted without access to assistive technologyATYetas disability severity increasesso does the challenge to findingan access movement that a person can perform to control AT andan access technology that can detect the access movementWe propose to create a wirele ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Selective inhibition of CYP26A1 in the skin for the treatment of ichthyosis

    SBC: Dermaxon LLC            Topic: NIAMS

    Project SummaryAbstract DermaXon s project goal is to develop efficacious substrate based and highly selective inhibitors of CYPsthe enzymes responsible or retinoic acidRAmetabolism in the epidermisfor the topical treatment of ichthyosisThis approach will provide a therapeutic advantage in ichthyosis without the potential adverse effects mediated by non targeted Pinhibitionassociated with previous ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Integrating CNV analysis into a NextGen sequencing clinical analytics platform

    SBC: Golden Helix, Inc.            Topic: 400

    Abstract The goal of this project is to develop a commercial analysis software platform that features the ability to detect and interpret copy number variantsCNVsand other types of structural variationsSVsfrom short read NextGen SequenceNGSdata to enable comprehensivewidely accessibleand economical genetic testingThis capability is key in clinical and research applicationsFor examplecurrently clin ...

    SBIR Phase II 2018 Department of Health and Human Services
  10. Improving STEM learning through digital technology simulating authentic research

    SBC: MEADOWLARK SCIENCE AND EDUCATION, LLC            Topic: 500

    Novel and effective techniques for imparting STEM based knowledge and concepts are increasingly in demand as our world becomes progressively computerized and complexWhile traditional teaching approaches have worked well in the past for many areas of studyresearch has shown that traditional teaching methods may diminish student engagement in scientific studieswhich are especially dynamic and consta ...

    STTR Phase I 2018 Department of Health and Human Services

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